1 Prospect Park W Suite C
Brooklyn NY 11215
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Accepts Medicare: No
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License #: 242393
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Photoselective vaporization of the prostate using a laser high performance system in the canine model. - The Journal of urology
Photoselective vaporization of the prostate with the 80 W KTP laser has been shown to be an effective and durable therapy for benign prostatic hyperplasia. We investigated the new, more powerful GreenLight HPS(R) High Performance System laser in the canine model as a more rapid treatment for benign prostatic hyperplasia.Five male beagles underwent general anesthesia and laparotomy. Photoselective vaporization of the prostate was performed in antegrade fashion through a suprapubic cystotomy at 40, 80 and 120 W at 3 firing periods (5, 10 and 20 seconds). Photoselective vaporization of the prostate was performed for each power and time combination in stationary fashion at unique locations. Prostates were harvested and histopathological analysis was performed. Mean vaporization and coagulation depths of each laser setting were determined and compared using ANOVA.Vaporization depth was 4 mm to full thickness. Coagulation occurred 1.2 to 2.5 mm deep to the vaporization zone. Increasing laser power appeared to increase depth of vaporization with equivalent or less coagulation depth and increasing the lasing duration behaved similarly. Microscopic pathological evaluation revealed damage to adjacent tissues in areas of full-thickness vaporization at the longest exposure times.The HPS laser is capable of greater power than the 80 W KTP system. HPS laser beam effects appeared more optically confined than those of its lower power brethren. It consistently vaporized more tissue during a given period while maintaining a 1 to 2 mm rim of coagulation, like its predecessors. The HPS should be applied carefully due to the ability to rapidly create full-thickness tissue vaporization.
Anticholinergics and central nervous system effects: are we confused? - Reviews in urology
The central nervous system (CNS) effects of anticholinergic agents have been documented in various patient populations and to varying degrees in case reports, brain-activity surrogates, and computerized cognitive testing. The older patient population with overactive bladder represents a group at increased risk of cognitive impairment and other CNS side effects associated with antimuscarinic agents. The complexity of the effect of anticholinergic agents on CNS function requires an increased level of careful investigation. Studies need to be performed in the at-risk population with multiple, validated tests at clinically prescribed doses in acute and chronic situations. These studies need to take into account the effect of commonly prescribed dosing regimens, with doses selected to represent with equivalent bladder potency. The alterations in the serum levels and parent/metabolite effects contributed by metabolic issues or drug delivery systems require special attention.
Morphology and the sperm penetration assay. - Fertility and sterility
To assess the ability of Kruger morphology to predict the outcome of the sperm penetration assay (SPA).A retrospective review using univariate and multivariate analysis, t tests, and logistic regression was performed to examine the correlation between Kruger morphology and the optimized zona-free hamster egg sperm penetration assay (O-HESPA).University hospital.One hundred fifteen private-practice patients who underwent semen analysis, including Kruger morphology and O-HESPA, as part of an infertility evaluation between 1997-2000 were retrospectively reviewed.Retrospective analysis of the sperm penetration assay.Univariate and multivariate analysis, Student's t test, and logistic regression were performed to analyze Kruger morphology, count, and viability and their relationship to SCI result.Univariate analysis demonstrated a statistically significant correlation between SCI and sperm count, viability, and Kruger morphology. Multivariate analysis demonstrated statistically significant correlations between SCI and count and viability. There was no correlation between Kruger morphology and SCI. Logistic regression was performed on the SCI results, using count, Kruger morphology, and viability. Sperm count was found to be the only variable that was statistically significant with respect to SCI results.This study demonstrated that Kruger morphology assessment cannot be used to predict the results of SCI or replace it in the management of the infertile couple.
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1 Prospect Park W Suite C Brooklyn, NY 11215
506 6Th St Ny Methodist Hospital