Dr. Christopher  Lynch  Phd image

Dr. Christopher Lynch Phd

100 Madison Ave. Morristown Memorial Hosptial Child Development Ctr
Morristown NJ 07962
973 715-5227
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 3586
NPI: 1962651448
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Oral aesthetic-related quality of life of muco-supported prosthesis and implant-retained overdenture wearers assessed by a new, short, specific scale (QoLDAS-9). - Journal of dentistry
To validate a new questionnaire for evaluating the 'Oral aesthetic-related quality of life (OARQoL)' of prosthetically restored patients. 'OARQoL' assesses the impact of the self-perceived dental aesthetics on patients' well-being.The 'Quality of Life associated with Dental Aesthetic Satisfaction (QoLDAS)' index was designed. After a pilot trial, 70 patients were distributed into two groups depending on their type of prosthetic rehabilitation: Group 1 (CD; n=34): muco-supported complete dentures, and Group 2 (IO; n=36): implant-retained overdentures. Patients answered the QoLDAS and the Oral Health Impact Profile (OHIP-20sp) questionnaires, and reported their satisfaction on a visual analogue scale (VAS). Socio-demographic and prosthesis-related factors were registered. Psychometric properties of the QoLDAS were investigated. Correlations between both indices were explored using the Spearman's rank test. Descriptive and non-parametric probes were run to evaluate the effect of the study variables on the OARQoL (α=0.05).The QoLDAS-9 was reliable and valid. The factor analysis confirmed the existence of three dimensions and meaningful inter-correlations among the nine finally included items. Both scales were inversely correlated. The self-reported aesthetic and functional satisfaction and the education level significantly modulated the OARQoL as measured with the QoLDAS-9.The QoLDAS-9 confirmed its psychometric capacity for assessing the OARQoL of CD and IO wearers. Both groups showed comparably high OARQoL. Superior education degrees lead to lower OARQoL.The QoLDAS-9 may be recommended for anticipating the effect of prosthetic restorations on OARQoL. CD and IO are predictable treatment options for improving the aesthetic self-perception of edentulous patients.Copyright © 2015. Published by Elsevier Ltd.
Effect of Preoperative Occlusal Matrices on the Vickers Microhardness of Composite Disks Polymerized with QTH and LED Lamps. - Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
This study aimed to assess the reliability of the preoperative occlusal matrix technique in terms of the surface Vickers microhardness (VMH) of the underlying composite restorative material.Two hundred microhybrid composite cylinders were built up and light-cured in a single-layer step, forming two experimental groups (N = 100) according to their heights (1.5 mm/2 mm). Each group was divided into five subgroups (N = 20) depending on the matrix thickness (no matrix/0.5 mm/1 mm/2 mm/3 mm). Half the specimens per subgroup (N = 10) were randomly polymerized with a quartz-tungsten-halogen (QTH) light-curing unit (LCU). The remaining half were cured using a light-emitting diode lamp. The top and bottom samples' sides were tested for VMH at 1 hour and 24 hours post-curing using a universal VMH machine. A multiple analysis of variance with repeated measurements for the "surface" factor and the Student-Newman-Keuls test were run (α = 0.05). Bottom/top microhardness ratios were compared with the empirically accepted limit (0.8). Surface topography was analyzed under a scanning electron microscope.The thinnest matrices provided the significantly best VMH values. LCU, disc height, and time also contributed to VMH. At 24 hours, 2-mm high discs polymerized with QTH resulted in inadequate microhardness ratios when 1-mm thick to 3-mm thick matrices were used.The thinnest matrices are the most recommendable ones.The esthetics and occlusal reproducibility achieved with customized occlusal matrices fabricated before cavity preparation have been widely demonstrated. However, their effect on the physical properties of the restorations deserves further investigation. Although more studies are necessary, the thinnest matrices seem to be the most suitable to preserve the composite surface VMH and the curing depth.© 2015 Wiley Periodicals, Inc.
Defining meal requirements for protein to optimize metabolic roles of amino acids. - The American journal of clinical nutrition
Dietary protein provides essential amino acids (EAAs) for the synthesis of new proteins plus an array of other metabolic functions; many of these functions are sensitive to postprandial plasma and intracellular amino acid concentrations. Recent research has focused on amino acids as metabolic signals that influence the rate of protein synthesis, inflammation responses, mitochondrial activity, and satiety, exerting their influence through signaling systems including mammalian/mechanistic target of rapamycin complex 1 (mTORC1), general control nonrepressed 2 (GCN2), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), serotonin, and insulin. These signals represent meal-based responses to dietary protein. The best characterized of these signals is the leucine-induced activation of mTORC1, which leads to the stimulation of skeletal muscle protein synthesis after ingestion of a meal that contains protein. The response of this metabolic pathway to dietary protein (i.e., meal threshold) declines with advancing age or reduced physical activity. Current dietary recommendations for protein are focused on total daily intake of 0.8 g/kg body weight, but new research suggests daily needs for older adults of ≥1.0 g/kg and identifies anabolic and metabolic benefits to consuming at least 20-30 g protein at a given meal. Resistance exercise appears to increase the efficiency of EAA use for muscle anabolism and to lower the meal threshold for stimulation of protein synthesis. Applying this information to a typical 3-meal-a-day dietary plan results in protein intakes that are well within the guidelines of the Dietary Reference Intakes for acceptable macronutrient intakes. The meal threshold concept for dietary protein emphasizes a need for redistribution of dietary protein for optimum metabolic health.© 2015 American Society for Nutrition.
RNA sequencing reveals a slow to fast muscle fiber type transition after olanzapine infusion in rats. - PloS one
Second generation antipsychotics (SGAs), like olanzapine, exhibit acute metabolic side effects leading to metabolic inflexibility, hyperglycemia, adiposity and diabetes. Understanding how SGAs affect the skeletal muscle transcriptome could elucidate approaches for mitigating these side effects. Male Sprague-Dawley rats were infused intravenously with vehicle or olanzapine for 24h using a dose leading to a mild hyperglycemia. RNA-Seq was performed on gastrocnemius muscle, followed by alignment of the data with the Rat Genome Assembly 5.0. Olanzapine altered expression of 1347 out of 26407 genes. Genes encoding skeletal muscle fiber-type specific sarcomeric, ion channel, glycolytic, O2- and Ca2+-handling, TCA cycle, vascularization and lipid oxidation proteins and pathways, along with NADH shuttles and LDH isoforms were affected. Bioinformatics analyses indicate that olanzapine decreased the expression of slower and more oxidative fiber type genes (e.g., type 1), while up regulating those for the most glycolytic and least metabolically flexible, fast twitch fiber type, IIb. Protein turnover genes, necessary to bring about transition, were also up regulated. Potential upstream regulators were also identified. Olanzapine appears to be rapidly affecting the muscle transcriptome to bring about a change to a fast-glycolytic fiber type. Such fiber types are more susceptible than slow muscle to atrophy, and such transitions are observed in chronic metabolic diseases. Thus these effects could contribute to the altered body composition and metabolic disease olanzapine causes. A potential interventional strategy is implicated because aerobic exercise, in contrast to resistance exercise, can oppose such slow to fast fiber transitions.
Validation of the 'Quality of Life with Implant Prostheses (QoLIP-10)' questionnaire for wearers of cement-retained implant-supported restorations. - Journal of dentistry
To validate the 'Quality of Life with Implant-Prostheses (QoLIP-10)' questionnaire for assessing the impact of cemented implant prostheses on Oral Health-Related Quality of Life (OHRQoL).84 subjects wearing implant restorations were distributed as follows: Group 1 (SD-I; n=35): screwed FDPs (fixed dental prostheses) supported by 2 implants; Group 2 (SD-II; n=7): screwed FDPs supported by 3-5 implants; Group 3 (CD-I; n=36): cemented FDPs supported by 2 implants; and Group 4 (CD-II; n=6): cemented FDPs supported by 3-5 implants. The QoLIP-10 and the Oral Health Impact Profile (OHIP-14sp) scales were used. Data related to global oral satisfaction, socio-demographics, health-behaviors, and prostheses, were gathered. Reliability and validity of the QoLIP-10 were investigated. Correlations between both indices were explored with the Spearman's rank test. Descriptive and non-parametric probes were run to evaluate the effect of the study variables on the OHRQoL (α=0.05).The QoLIP-10 confirmed its psychometric capacity for cemented implant prosthesis wearers. Both tests were inversely correlated. The QoLIP-10 attributed the significantly worst QoL to long-span cemented prostheses. Groups were significantly discriminated by the QoLIP-10 performance dimension. The variable complaints about the mouth and the three global oral satisfaction measures significantly modulated the OHRQoL.Patient satisfaction depends upon the extension and the type of retention of implant FDPs.The QoLIP-10 may help estimating the effect of cemented FDPs on patients' well-being. When compared to screwed FDPs, short cemented implant restorations lead to greater improvements in patients' self-perceived QoL.Copyright © 2015 Elsevier Ltd. All rights reserved.
Health professions ethics rubric: validation of reliability in an interprofessional health ethics course. - Journal of dental education
The aim of this study was to validate a health professions ethics rubric by an interprofessional team. The rubric was used by two pharmacy and two dental faculty members to score ethics cases submitted by 16 teams comprised of 80 pharmacy and 50 dental students. A debriefing session for each case was moderated by a non-rater faculty member to arrive at a consensus score for the cases. Interrater reliability was calculated for the four raters and the debriefing scores as well as the four raters without the debriefing scores. The overall interrater correlations were in the range of 0.790 to 0.906 for the four raters. Issues ranged from 0.320 to 0.758. Principles ranged from 0.610 to 0.838. Options ranged from 0.655 to 0.843. Analysis ranged from 0.667 to 0.918. Solution ranged from 0.739 to 0.886. With the inclusion of the consensus scores, the interrater correlations were even higher. The best correlations were for the overall score and solution components of the rubric. With further edits in the rubric and enhanced training by faculty raters and changes in the ethics learning session, the revised rubric could be evaluated again for grading. Further training for faculty using the rubric for grading student cases should enhance its reliability. Demonstrating to students the ethical decision making process using the rubric should enhance the validation process.
A rare case of anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. - The New Zealand medical journal
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was first described as a severe form of encephalitis by Dalmau et al in 2006. This is an autoimmune disorder usually associated with paraneoplastic mechanism that manifests as neuropsychiatric disorder affecting mainly women of child-bearing age. Nevertheless anti- NMDA receptor encephalitis is a rare condition during pregnancy. To -date, there have been only four reported cases during pregnancy. We report a case of a 23-year-old primigravida in first trimester pregnancy with altered mental status and multiple neurological symptoms related to anti-NMDA receptor encephalitis. To the best of our knowledge, this is the first reported anti-NMDA receptor encephalitis during pregnancy in Australasia.
Improving the quality of papers submitted to dental journals: Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Cape Town on Wednesday, 25 June 2014. - Journal of dentistry
This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an emphasis on how the quality of papers submitted to dental journals could be improved. The panel included representation from editors, researchers and publishers from North America, India and the Gulf States. The symposium identified a number of challenges for editors and publishers, including the poor quality of many papers submitted to dental and other scientific journals, plagiarism, attempted duplicate publication and sometimes fraudulent results. Where possible speakers are identified by name. A subsequent symposium was held during the IADR meeting in Boston on March 11th 2015. Involvement open to editors, associate editors, publishers and others with an interest in scientific publishing.Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.
Use of guidelines to improve the quality and transparency of reporting oral health research. - Journal of dentistry
The use of reporting guideline is directed at enhancing the completeness and transparency of biomedical publications. The aims of this paper are to present some of the key initiatives and guidelines providing indications and directions on the use of specific tools in oral health research.The EQUATOR Network and five established guidelines (CONSORT, STROBE, PRISMA, CARE and SPIRIT) are introduced.Five guidelines are presented covering reporting of case reports, non-randomized studies, randomized controlled trials and systematic reviews. The importance of adherence to these guidelines by oral health researchers is emphasized.Endorsement and robust implementation of reporting guidelines will translate into improved and more complete reporting in health research. Moreover, by ingraining the use of guidelines, it may be possible to indirectly improve the methodological quality of clinical studies. Active implementation strategies to encourage adherence to these guidelines among researchers, reviewers, editors and publishers may be an important facet in the advancement of knowledge in dentistry.Inadequate reporting of research can lead to wasted research resources and risks publication of inaccurate or misleading findings with implications on healthcare decisions. Familiarity and diligent compliance with methodological and reporting guidelines are therefore essential to maximize the yield from dental research.Copyright © 2015 Elsevier Ltd. All rights reserved.
Effects of composition and temperature on the large-field behavior of [001]C relaxor single crystals. - IEEE transactions on ultrasonics, ferroelectrics, and frequency control
The compositional dependence of the large-field behavior of [001]C-cut relaxor ferroelectric xPb(In1/2Nb1/2) O3-(1-x-y)Pb(Mg1/3Nb2/3)O3-yPbTiO3 (PIN-PMN-PT) single crystals that are on the rhombohedral side of the morphotropic phase boundary was characterized under electrical, mechanical, and thermal loading. The effects of varying the concentrations of PIN and PT are discussed. Composition was found to impact the material constants and the field-induced phase transformation threshold in the piezoelectric d333-mode configuration.

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