703 Main St St. Joseph's Children's Hospital- Rm X609
Paterson NJ 07503
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Near Band Edge Emission by Free Exciton Decay and Intrinsic Ferromagnetic Ordering of Cu-Doped SnO2 Hollow Nanofibers. - Journal of nanoscience and nanotechnology
High quality nanocrystalline pristine and Cu-doped SnO2 hollow nanofibers were successfully prepared through simple and effective electrospinning technique. Nanofibers calcined at 600 Â°C for 3 h were characterized with different analytical techniques such as X-ray diffraction (XRD), Transmission electron Microscope (TEM) and Vibrating sample magnetometer (VSM). Observed TEM images and XRD patterns were corroborate to the formation of tetragonal crystalline SnO2 hollow nanofibers with rutile phase. Excellent optical behaviour was observed for Cu-doped SnO2. Highly intense near band edge emission at 3.58 eV for Cu-doped SnO2 evidences the free exciton decay process in the hollow nanofibers. For the first time we have reported here the near band edge PL emission in Cu-doped SnO2 tubular hollow nanostructure. This study substantiates that material potential for UV-lasing application. In addition to the above, magnetic measurement ascribes that Cu-doped SnO2 exhibit the intrinsic room temperature ferromagnetism within the low field strength. The occurrence of ferromagnetism in Cu-doped SnO2 is directly related to the p-d ferromagnetic exchange coupling between the local magnetic moment of Cu2+ and the polarized valence electrons of surrounding oxygen. Over all this study provides the primary information about tunable multifunctionality of SnO2 hollow nanostructures by adding the non-magnetic Cu ions.
Identifying Early Onset of Hearing Loss in Young Adults With Diabetes Mellitus Type 2 Using High Frequency Audiometry. - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
Diabetes mellitus (DM) is a metabolic disorder caused by hyperglycemia which leads to dysfunction of various organs. Hearing acuity is equally hindered by this disorder. Among individuals with DM audiological characteristics of DM type 1 are of great concern in the literature. This study aims at establishing high frequency audiometry (HFA) as a useful tool in identifying early onset of hearing loss in individuals with DM type 2. 20 non-diabetic participants and 20 individuals with DM type 2 in the age range of 20-40Â years were considered for the study. Subjects in both groups underwent otoscopic examination, PTA at 0.25, 0.5, 1, 2, 4 and 8Â kHz and HFA at 9, 10, 11.2, 12.5, 14 and 16Â kHz. Results revealed statistically significant difference in thresholds of both PTA and HFA at all frequencies across the group, but the mean threshold difference between the diabetic and non-diabetic group was marked in HFA than in PTA. In the diabetic subjects the thresholds of PTA was within 25Â dBHL at all frequencies when compared to the thresholds of HFA. Individuals with DM type 2 showed bilateral symmetrical mild hearing loss in HFA and the hearing loss increased with ascending test frequencies from 9,000 to 16,000Â Hz. Mild hearing loss in HFA is an indicator for early onset of hearing loss in DM type 2. Hence this present study emphasis the clinical utility of HFA in young adults with DM type 2.
Prevalence and referral rates in neonatal hearing screening program using two step hearing screening protocol in Chennai - A prospective study. - International journal of pediatric otorhinolaryngology
To estimate the prevalence and referral rates in well born and high risk babies using two step hearing screening protocol with Distortion Product Otoacoustic Emissions (DPOAE) and Automated Auditory Brainstem Response (AABR).A prospective study was carried out on 1405 neonates (983 well born babies and 422 high risk babies) who were screened during May 2013 to January 2015 at Institute of Obstetrics and Gynecology, Madras Medical College, Chennai. All neonates were screened using two step screening protocol. They were initially tested with DPOAE. Referred babies in DPOAE were screened with AABR subsequently.Among 1405 (100%) neonates 983 (69.96%) were well born babies and 422 (30.03%) were high risk babies. Total referral rate in DPOAE was found to be 311 (22.13%) among which 195 (13.87%) were well born babies and 116 (8.25%) were high risk babies. Out of 311 babies 31 (2.20%) babies were referred in AABR screening. In 31 babies referred in AABR 11(0.78%) were from well born group and 20 (1.42%) were from the high risk group. Further diagnostic evaluation of these babies, 2 (0.14%) were confirmed to have hearing loss. This study reveals, the prevalence of congenital hearing loss in our population is 1.42 per 1000 babies.Using two step protocol especially AABR along with DPOAE at the initial level of testing significantly reduces referral rates in new born screening programs. Also AABR decreases the false positive responses hence increasing the efficiency of screening program.Copyright Â© 2015 Elsevier Ireland Ltd. All rights reserved.
Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non-denaturing IEF fractionation. - Electrophoresis
Characterization of both the acidic and basic regions of imaged capillary isoelectric focusing (icIEF) profile of an IgG1 antibody was achieved through preparative immobilized pH gradient isoelectric focusing (IPG-IEF) fractionation. Recent attempts at using this method to fractionate charge variants of monoclonal antibodies (mAbs) have shown promising results, but identification of the chemical modifications in the variants was limited to the basic species. We have optimized the method to achieve enrichment of each variant across the icIEF profile of an IgG1 mAb. The fractionation was followed by extended characterization to elucidate the composition of the acidic, main, and basic species observed in the icIEF profile. Deamidation, sialylation, glycation, and fragmentation were identified as the main modifications contributing to acidic variants of the mAb while C-terminal lysine, C-terminal proline amidation, and uncyclized N-terminal glutamine were the major species contributing to the basic variants. This characterization allows a better understanding of the modifications that contribute to the charge variants observed by icIEF, facilitating the evaluation of impacts on product safety and efficacy.Â© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Synthesis of biodiesel from pongamia oil using heterogeneous ion-exchange resin catalyst. - Ecotoxicology and environmental safety
Biodiesel is a clean-burning renewable substitute fuel for petroleum. Biodiesel could be effectively produced by transesterification reaction of triglycerides of vegetable oils with short-chain alcohols in the presence of homogeneous or heterogeneous catalysts. Conventionally, biodiesel manufacturing processes employ strong acids or bases as catalysts. But, separation of the catalyst and the by-product glycerol from the product ester is too expensive to justify the product use as an automobile fuel. Hence heterogeneous catalysts are preferred. In this study, transesterification of pongamia oil with ethanol was performed using a solid ion-exchange resin catalyst. It is a macro porous strongly basic anion exchange resin. The process parameters affecting the ethyl ester yield were investigated. The reaction conditions were optimized for the maximum yield of fatty acid ethyl ester (FAEE) of pongamia oil. The properties of FAEE were compared with accepted standards of biodiesel. Engine performance was also studied with pongamia oil diesel blend and engine emission characteristics were observed.Copyright Â© 2015 Elsevier Inc. All rights reserved.
Randomized Comparison of Extrafascial Versus Subfascial Injection of Local Anesthetic During Ultrasound-Guided Supraclavicular Brachial Plexus Block. - Regional anesthesia and pain medicine
The optimal site for local anesthetic injection during an ultrasound-guided supraclavicular brachial plexus block (BPB) is not known. We tested the hypothesis that local anesthetic injected deep to the "brachial plexus sheath" during supraclavicular BPB would produce faster onset of surgical anesthesia than an injection superficial to the sheath.After research ethics approval and informed consent, 32 patients undergoing upper-extremity surgery under an ultrasound-guided supraclavicular BPB were randomly assigned to receive 25 mL of a 1:1 mixture of 2% lidocaine with 1:200,000 epinephrine and 0.5% bupivacaine, deep to (subfascial, Gp SF) or superficial to (extrafascial, Gp EF) the brachial plexus sheath. Sensory-motor blockade of the ipsilateral musculocutaneous, median, radial, and ulnar nerves and time to "readiness for surgery" (defined as a sensory and motor block scale of 1 in all the 4 nerves tested) were assessed by a blinded observer, using a 3-point qualitative scale (2 to 0), every 5 minutes for 40 minutes and at 2, 4, 6, 8, 10, 12, and 24 hours after surgery.The time to "readiness for surgery" was significantly shorter (Gp SF: 7 Â± 3 minutes vs Gp EF: 20 Â± 10 minutes; P < 0.001), and the duration of postoperative analgesia was longer (Gp SF: 9.3 Â± 1.4 hours vs Gp EF: 6.1 Â± 1.4 hours; P < 0.001) in the subfascial group than in the extrafascial group. There were no complications directly related to the technique or the local anesthetic injection.Injection of local anesthetic deep to the brachial plexus sheath at the supraclavicular fossa, under ultrasound-guidance, results in faster onset of surgical anesthesia and prolonged duration of postoperative analgesia than an injection superficial to the sheath.
Detection of Hard Exudates in Colour Fundus Images Using Fuzzy Support Vector Machine-Based Expert System. - Journal of digital imaging
Diabetic retinopathy is a major cause of vision loss in diabetic patients. Currently, there is a need for making decisions using intelligent computer algorithms when screening a large volume of data. This paper presents an expert decision-making system designed using a fuzzy support vector machine (FSVM) classifier to detect hard exudates in fundus images. The optic discs in the colour fundus images are segmented to avoid false alarms using morphological operations and based on circular Hough transform. To discriminate between the exudates and the non-exudates pixels, colour and texture features are extracted from the images. These features are given as input to the FSVM classifier. The classifier analysed 200 retinal images collected from diabetic retinopathy screening programmes. The tests made on the retinal images show that the proposed detection system has better discriminating power than the conventional support vector machine. With the best combination of FSVM and features sets, the area under the receiver operating characteristic curve reached 0.9606, which corresponds to a sensitivity of 94.1Â % with a specificity of 90.0Â %. The results suggest that detecting hard exudates using FSVM contribute to computer-assisted detection of diabetic retinopathy and as a decision support system for ophthalmologists.
Immunogenicity of a Candidate DNA Vaccine Based on the prM/E Genes of a Dengue Type 2 Virus Cosmopolitan Genotype Strain. - Japanese journal of infectious diseases
The development of a dengue virus vaccine is a major priority in efforts to control the diseases. Several researchers are currently using the Asian 1 and Asian 2 genotypes as vaccine candidates for dengue type 2 virus (DENV-2). However, in this study, we constructed a recombinant plasmid-based prM/E gene, from a DENV-2 Cosmopolitan genotype strain as a dengue DNA vaccine candidate. The protein expression of the recombinant plasmid in CHO cells was analyzed using an enzyme-linked immunosorbent assay, western blotting, and sucrose gradient sedimentation. After being used to immunize ddY mice three times at doses of 25 or 100 Î¼g, the DNA vaccine induced humoral immune responses. There was no difference in the neutralizing antibody titer (focus reduction neutralization test 50% value) of mice immunized with 25 and 100 Î¼g DNA vaccine doses. When challenged with 3 Ã— 10(5) FFU DENV-2, immunized mice could raise anamnestic neutralizing antibody responses, which were observed at day 4 and day 8 post-challenge. Analysis of immunogenicity using BALB/c mice showed that their antibody neutralization titers were lower than those of ddY mice. In addition, the antibodies produced after immunization and challenge could also neutralize a DENV-2 Asian 2 genotype (New Guinea C) strain. Therefore, the DENV-2 Cosmopolitan genotype may be a DENV-2 vaccine candidate.
A first study on the incidence and prevalence of IBD in Malaysia--results from the Kinta Valley IBD Epidemiology Study. - Journal of Crohn's & colitis
Inflammatory bowel disease [IBD] is known to be rare in the Asia Pacific region but epidemiological studies are scarce.Kinta Valley [Ipoh] was chosen as the sample population. Malaysia has a multiethnic population consisting of Malays, Chinese, and Indians. New cases over 2 years were prospectively captured as well as all known existing cases. Total numbers of the population as a whole and of each ethnic group were obtained. Incidence, prevalence, and mean incidence over two decades were then calculated.There were 10 new cases of IBD diagnosed from April 2011 to April 2013. The crude incidence rates of IBD, ulcerative colitis [UC], and Crohn's disease[CD], respectively, were 0.68, 0.46, and 0.20 per 100,000 persons. The highest incidence was among the Indians, 1.91 compared with 0.35 and 0.63 per 100,000 persons among the Malays and the Chinese, respectively. The mean incidence of IBD has increased steadily from 0.07 to 0.69 per 100,000 person-years over the past two decades. The UC:CD ratio was 8:1 from 1990 to 2000 and 3.6:1 from 2000 to 2010. The prevalence rates of IBD, UC, and CD, respectively, were 9.24, 6.67, and 2.17 per 100,000 persons. The highest prevalence also was among the Indians: 24.91 compared with 7.00 and 6.90 per 100,000 persons among the Malay and Chinese races, respectively.The incidence and prevalence rates of IBD are low in Malaysia but the incidence appears to be increasing and marked racial differences exist. As in other Asian countries, the incidence of CD is increasing at a more rapid rate relative to UC.Copyright Â© 2015 European Crohnâ€™s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: email@example.com.
Metal pollution of groundwater in the vicinity of Valiathura Sewage Farm in Kerala, south India. - Bulletin of environmental contamination and toxicology
A comprehensive study was conducted to evaluate metal pollution of groundwater in the vicinity of Valiathura Sewage Farm in Thiruvananthapuram district, Kerala using the Heavy Metal Pollution Index (HPI). Forty two groundwater samples were collected during the summer season (April 2010) and the concentration of metals Fe, Cu, Zn, Cd and Pb were analyzed. Results showed that groundwater was contaminated mainly with Fe, Cu and Pb. Correlation analysis revealed that the sources of metals in groundwater in the study area are the same, and it may be due to the leachates from the nearby Sewage Farm, Parvathy Puthanar canal and solid wastes dumped in the residential area. Of the groundwater samples studied, 47.62 % were medium and 2.68 % were classified in HPI high category. HPI was highest (41.79) in DW29, which was adjacent to the polluted Parvathy Puthanar canal and Sewage Farm. The present study points out that the metal pollution causes the degradation of groundwater quality around the Sewage Farm during the study period.
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703 Main St St. Joseph's Children's Hospital- Rm X609 Paterson, NJ 07503
703 Main St St. Josephs Regional Medical Center
703 Main St St. Joseph's Regional Medical Center
703 Main St St. Joseph's Regional Medical Center