Docality.com Logo
 
Dr. Seonha  Park  Dmd image

Dr. Seonha Park Dmd

1795 Main St Suite 212
Springfield MA 01103
413 325-5600
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: DN1856528
NPI: 1932516929
Taxonomy Codes:
122300000X

Request Appointment Information

Awards & Recognitions

About Us

Practice Philosophy

Conditions

Medical Malpractice Cases

None Found

Medical Board Sanctions

None Found

Referrals

None Found

Publications

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. - The Journal of neuroscience : the official journal of the Society for Neuroscience
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid-β (Aβ) accumulation in the brain plays a critical role in AD pathogenesis. Like in humans, apoE4 expression in animal models that develop Aβ amyloidosis results in greater Aβ and amyloid deposition than with apoE3 expression. However, whether decreasing levels of apoE3 or apoE4 would promote or attenuate Aβ-related pathology has not been directly addressed. To determine the effect of decreasing human apoE levels on Aβ accumulation in vivo, we generated human APOE isoform haploinsufficient mouse models by crossing APPPS1-21 mice with APOE isoform knock-in mice. By genetically manipulating APOE gene dosage, we demonstrate that decreasing human apoE levels, regardless of isoform status, results in significantly decreased amyloid plaque deposition and microglial activation. These differences in amyloid load between apoE3- and apoE4-expressing mice were not due to apoE4 protein being present at lower levels than apoE3. These data suggest that current therapeutic strategies to increase apoE levels without altering its lipidation state may actually worsen Aβ amyloidosis, while increasing apoE degradation or inhibiting its synthesis may be a more effective treatment approach.

Map & Directions

1795 Main St Suite 212 Springfield, MA 01103
View Directions In Google Maps

Nearby Doctors

125 Liberty St
Springfield, MA 01103
413 343-3222
1795 Main St Suite 116
Springfield, MA 01103
413 951-1343
281 State St Suite 1F
Springfield, MA 01103
413 352-2558
1795 Main St Suite 215
Springfield, MA 01103
413 336-6651
273 State St
Springfield, MA 01103
413 363-3668
120 Maple St Ste 204
Springfield, MA 01103
413 461-1016
1350 Main St Ste 1007
Springfield, MA 01103
413 277-7400
1795 Main St
Springfield, MA 01103
413 327-7208
1795 Main St Ste. 202
Springfield, MA 01103
617 948-8527
125 Liberty St Suite 308
Springfield, MA 01103
413 377-7300