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Dr. William  Cao  Md image

Dr. William Cao Md

115 Locust St
Santa Cruz CA 95060
831 525-5670
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: A66603
NPI: 1932189529
Taxonomy Codes:
207Q00000X

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An evaluation of a human stem cell line to identify risk of developmental neurotoxicity with antiepileptic drugs. - Toxicology in vitro : an international journal published in association with BIBRA
Determination of the impact of a drug on human brain development relies instead on surrogate animal studies. Here we have exploited the human stem cell line, TERA2.cl.SP12 to differentiate into neurons and addressed their value as an in vitro model to evaluate the risk of developmental neurotoxicity with antiepileptic drugs (AEDs). The effects of four AEDs were investigated on cell viability, cell cycle and neural differentiation. Exposure to either phenobarbital (10-1000 μM), valproic acid (10-1000 μM), lamotrigine (1-100 μM) or carbamazepine (1-100 μM) for 3 days reduced viability in non-differentiating cells only at the highest concentrations tested. Viability was also reduced with lower concentrations of all AEDs in cells undergoing neural differentiation. Valproic acid and carbamazepine increased DNA fragmentation and reduced cell cycle progression. 3 days exposure at the start of neural differentiation to phenobarbital, valproic acid or lamotrigine also significantly reduced the proportion of stem cells that subsequently differentiated into neurons at 15 days in vitro. The two control agents tested, ciprofloxacin and perfluorooctanoic acid had no impact on neurogenesis in vitro. These new data show that modelling neurogenesis in vitro using a human stem cell line may be a powerful method to predict risks of developmental neurotoxicity in vivo with psychotropic drugs.Copyright © 2015 Elsevier Ltd. All rights reserved.

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115 Locust St Santa Cruz, CA 95060
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