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Dr. Nandita  Singh  Do image

Dr. Nandita Singh Do

19 Bradhurst Ave Suite 200N
Hawthorne NY 10532
914 937-7701
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 235493
NPI: 1912108937
Taxonomy Codes:
207R00000X 207RN0300X

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Publications

Brevundimonas diminuta mediated alleviation of arsenic toxicity and plant growth promotion in Oryza sativa L. - Ecotoxicology and environmental safety
Arsenic (As), a toxic metalloid adversely affects plant growth in polluted areas. In the present study, we investigated the possibility of improving phytostablization of arsenic through application of new isolated strain Brevundimonas diminuta (NBRI012) in rice plant [Oryza sativa (L.) Var. Sarju 52] at two different concentrations [10ppm (low toxic) and 50ppm (high toxic)] of As. The plant growth promoting traits of bacterial strains revealed the inherent ability of siderophores, phosphate solubilisation, indole acetic acid (IAA), 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase production which may be associated with increased biomass, chlorophyll and MDA content of rice and thereby promoting plant growth. The study also revealed the As accumulation property of NBRI012 strain which could play an important role in As removal from contaminated soil. Furthermore, NBRI012 inoculation significantly restored the hampered root epidermal and cortical cell growth of rice plant and root hair elimination. Altogether our study highlights the multifarious role of B. diminuta in mediating stress tolerance and modulating translocation of As in edible part of rice plant.Copyright © 2015 Elsevier Inc. All rights reserved.
ANN modelling of sediment concentration in the dynamic glacial environment of Gangotri in Himalaya. - Environmental monitoring and assessment
The present study explores for the first time the possibility of modelling sediment concentration with artificial neural networks (ANNs) at Gangotri, the source of Bhagirathi River in the Himalaya. Discharge, rainfall and temperature have been considered as the main controlling factors of variations in sediment concentration in the dynamic glacial environment of Gangotri. Fourteen feed forward neural networks with error back propagation algorithm have been created, trained and tested for prediction of sediment concentration. Seven models (T1-T7) have been trained and tested in the non-updating mode whereas remaining seven models (T1a-T7a) have been trained in the updating mode. The non-updating mode refers to the scenario where antecedent time (previous time step) values are not used as input to the model. In case of the updating mode, antecedent time values are used as network inputs. The inputs applied in the models are either the variables mentioned above as individual factors (single input networks) or a combination of them (multi-input networks). The suitability of employing antecedent time-step values as network inputs has hence been checked by comparative analysis of model performance in the two modes. The simple feed forward network has been improvised with a series parallel non-linear autoregressive with exogenous input (NARX) architecture wherein true values of sediment concentration have been fed as input during training. In the glacial scenario of Gangotri, maximum sediment movement takes place during the melt period (May-October). Hence, daily data of discharge, rainfall, temperature and sediment concentration for five consecutive melt periods (May-October, 2000-2004) have been used for modelling. High Coefficient of determination values [0.77-0.88] have been obtained between observed and ANN-predicted values of sediment concentration. The study has brought out relationships between variables that are not reflected in normal statistical analysis. A strong rainfall: sediment concentration and temperature: sediment concentration relationship is shown by the models which are not reflected in statistical correlation. It has also been observed that usage of antecedent time-step values as network inputs does not necessarily lead to improvement in model performance.
Mapping of arsenic pollution with reference to paddy cultivation in the middle Indo-Gangetic Plains. - Environmental monitoring and assessment
A detailed field study was carried out to monitor (i) the arsenic contents in irrigation groundwater and paddy soil and (ii) the accumulation of arsenic in the roots and grains of different paddy varieties grown in the arsenic-contaminated middle Indo-Gangetic Plains of Northern India. Results showed the highest arsenic contamination in the irrigation groundwater (312 μg l(-1)) and in paddy soil (35 mg kg(-1)) values that were significantly exceeded the recommended threshold values of 100 μg l(-1) (EU) and 20 mg kg(-1) (FAO), respectively. The paddy soil arsenic content ranged from 3 to 35 mg kg(-1) with a mean value of 15 mg kg(-1). The soil arsenic content was found to be influenced by the soil texture, carbon, macronutrients, phosphorus, sulfur, hydrolases, and oxidoreductases properties of the paddy soils as revealed in the principal component analyses. Higher root accumulation (>10 mg kg(-1)) of arsenic was observed in 6 of the 17 paddy varieties grown in the study area. The range of arsenic content accumulated in the paddy roots was 4.1 to 16.2 mg kg(-1) dry weight (dw) and in the grains 0.179 to 0.932 mg kg(-1) dw. Out of 17 paddy varieties, eight had 0 > .55 mg kg(-1) grain arsenic content and were found unsafe for subsistence maximum daily tolerable dietary intake (MTDI) by human beings according to the regulatory standards.
Phytoremediation of arsenic contaminated soil by arsenic accumulators: a three year study. - Bulletin of environmental contamination and toxicology
To investigate whether phytoremediation can remove arsenic from the contaminated area, a study was conducted for three consecutive years to determine the efficiency of Pteris vittata, Adiantum capillus veneris, Christella dentata and Phragmites karka, on arsenic removal from the arsenic contaminated soil. Arsenic concentrations in the soil samples were analysed after harvesting in 2009, 2010 and 2011 at an interval of 6 months. Frond arsenic concentrations were also estimated in all the successive harvests. Fronds resulted in the greatest amount of arsenic removal. Root arsenic concentrations were analysed in the last harvest. Approximately 70 % of arsenic was removed by P. vittata which was recorded as the highest among the four plant species. However, 60 % of arsenic was removed by A. capillus veneris, 55.1 % by C. dentata and 56.1 % by P. karka of arsenic was removed from the contaminated soil in 3 years.
Chitosan silk-based three-dimensional scaffolds containing gentamicin-encapsulated calcium alginate beads for drug administration and blood compatibility. - Journal of biomaterials applications
In the present study gentamicin was encapsulated within calcium alginate beads and incorporated into porous chitosan, gelatin, double-hybrid silk fibroin, chitosan/gelatin and double-hybrid silk fibroin/chitosan scaffolds. Physiochemical, morphological and biological properties of fabricated amenable model systems were evaluated, revealing hemocompatible nature of double-hybrid silk fibroin/chitosan and double-hybrid silk fibroin scaffolds of hemolysis %<5 and porosity >85%. Fourier transform infrared results confirmed the blend formation and scanning electron microscope images showed good interconnectivity. Double-hybrid silk fibroin/chitosan-blended scaffold shows higher compressive strength and compressive modulus than other fabricated scaffolds. A comparative drug release profile of fabricated scaffolds revealed that double-hybrid silk fibroin/chitosan scaffold is a pertinent model system because of its prolonged drug release, optimal hemocompatability and high compressive modulus.© The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Feasibility Study of Phragmites karka and Christella dentata Grown in West Bengal as Arsenic Accumulator. - International journal of phytoremediation
A survey was undertaken, in arsenic (As) contaminated area of the Nadia district, West Bengal, India, to find native As accumulator plants. As was determined both in soil and plant parts. The results showed that the mean translocation factor of Pteris vittata L, Phragmites karka (Cav.) Trin. Ex. Steud and Christella dentata Forssk were higher than 1. It thus appeared that these plants can be efficient accumulators of As. Phytoremediation ability of C. dentata and P. karka was evaluated and compared with known As-hyperaccumulators -P. vittata and Adiantum capillus veneris L. Plants were grown in the As spiked soil (25, 50, 75 and 100 mg kg(-1)). As accumulation was found to be highest in P. vittata, 117.18 mg kg(-1) in leaf at 100 mg kg(-1) As treatment, followed by A. capillus veneris, P. karka and C. dentata being 74, 83.87 and 40.36 mg kg(-1), respectively. Lipid peroxidation increased after As exposure in all plants. However, the antioxidant enzyme activity and molecules concentration also increased which helped the plants to overcome As-induced oxidative stress. The study indicates that P. karka and C. dentata could be considered as As-accumulators and find application for As-phytoextraction in field conditions.
Phytodiversity on fly ash deposits: evaluation of naturally colonized species for sustainable phytorestoration. - Environmental science and pollution research international
Proliferation of fly ash (FA) deposits and its toxicity have become a global concern, which contaminate the ecosystems of our Earth. In this regard, identification of potential plant species for FA deposits' restoration is the main concern. Keeping this view in mind, the present study was conducted to identify potential plant species naturally growing on FA deposits for the restoration purposes. Six intensive surveys were made during 2010-2014 to collect naturally growing plant species during different seasons from two FA deposits in Unchahar of Raebareli district, Uttar Pradesh, India. The plant species having potential for FA deposits' restoration were identified on the basis of their ecological importance, dominance at the study sites and socio-economic importance for rural livelihoods. Typha latifolia L., Cynodon dactylon (L.) Pers., Saccharum spontaneum L., Saccharum bengalense Retz. (syn. Saccharum munja), Prosopis juliflora (Sw.) DC., Ipomoea carnea Jacq. and Acacia nelotica L. are identified as potential plant species for FA deposits' restoration. Furthermore, the characteristics of naturally colonized species can be used for the phytorestoration during a revegetation plan of new FA deposits for multiple benefits.
Phytoextraction and dissipation of lindane by Spinacia oleracea L. - Ecotoxicology and environmental safety
Remediation and management of organochlorine pesticide (OCPs) contaminated soil is becoming a global priority as they are listed in the Stockholm list of persistent organic pollutants (POPs) for global elimination. Lindane is a OCPs candidate recently included in the Stockholm list. However, India has an exemption to produce lindane for malaria control. Because of its widespread use during the last few decades, lindane contaminated soils are found in almost all parts of India. Since phytoremediation is widely acknowledged as an innovative strategy for the clean-up of contaminated soils; the present study was aimed to evaluate the phytoextraction and dissipation of lindane by a leafy vegetable Spinacia oleracea L (Spinach). The test plant was grown in different concentrations of lindane (5, 10, 15 and 20 mg kg(-1)) and harvested at 10, 30 and 45 days. At 45 days, the concentrations of lindane in root and leaf of Spinach growing in four different concentrations were reached up to 3.5, 5.4, 7.6 and 12.3 mg kg(-1) and 1.8, 2.2, 3 and 4.9 mg kg(-1), respectively. There was a significant difference (p<0.01) in the dissipation of lindane in vegetated and non-vegetated soil. Moreover, the residual lindane in four experiments was reduced to 81, 76, 69 and 61 percent, respectively. The experimental results indicate that Spinach can be used for the phytoremediation of lindane. However, more studies are required to prevent the toxicity of harvested parts.Copyright © 2014 Elsevier Inc. All rights reserved.
Uptake and accumulation of endosulfan isomers and its metabolite endosulfan sulfate in naturally growing plants of contaminated area. - Ecotoxicology and environmental safety
Endosulfan isomers (α+β) and its main metabolite endosulfan sulfate were analyzed in naturally growing vegetation of pesticide contaminated area in Ghaziabad, India. Seven species of dominating plants were collected at different locations within the contaminated area. Endosulfan residues from plant parts and soil were extracted and determined by a gas chromatograph equipped with 63Ni electron capture detector (GC-ECD). Endosulfan isomers and endosulfan sulfate were present in almost all soil and plant samples. The concentration of total endosulfan in plant and soil samples analyzed ranged from 14 to 343ng g(-1) and 13 to 938ng g(-1) respectively. Out of seven plant species studied, Vetiveria zizanioides (Khus Khus) and Sphenoclea zeylamica (Chikenspike) showed the highest and lowest accumulation respectively, with a significant difference at p<0.01 level. Vetiveria zizanioides and Digitaria longiflora (Crab grass) could accumulate considerable levels of endosulfan isomers (α+β) (343 and 163ng g(-1) respectively) and endosulfan sulfate (21 and 2ng g(-1), respectively). The outcomes of the study reflect the value of test species in monitoring purposes and their potential for remediation of contaminated sites.Copyright © 2014 Elsevier Inc. All rights reserved.
Directing chondrogenesis of stem cells with specific blends of cellulose and silk. - Biomacromolecules
Biomaterials that can stimulate stem cell differentiation without growth factor supplementation provide potent and cost-effective scaffolds for regenerative medicine. We hypothesize that a scaffold prepared from cellulose and silk blends can direct stem cell chondrogenic fate. We systematically prepared cellulose blends with silk at different compositions using an environmentally benign processing method based on ionic liquids as a common solvent. We tested the effect of blend compositions on the physical properties of the materials as well as on their ability to support mesenchymal stem cell (MSC) growth and chondrogenic differentiation. The stiffness and tensile strength of cellulose was significantly reduced by blending with silk. The characterized materials were tested using MSCs derived from four different patients. Growing MSCs on a specific blend combination of cellulose and silk in a 75:25 ratio significantly upregulated the chondrogenic marker genes SOX9, aggrecan, and type II collagen in the absence of specific growth factors. This chondrogenic effect was neither found with neat cellulose nor the cellulose/silk 50:50 blend composition. No adipogenic or osteogenic differentiation was detected on the blends, suggesting that the cellulose/silk 75:25 blend induced specific stem cell differentiation into the chondrogenic lineage without addition of the soluble growth factor TGF-β. The cellulose/silk blend we identified can be used both for in vitro tissue engineering and as an implantable device for stimulating endogenous stem cells to initiate cartilage repair.

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