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Dr. Jean  Hoang  Od image

Dr. Jean Hoang Od

3951 Grand Ave
Chino CA 91710
909 271-1507
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 12816T
NPI: 1902980147
Taxonomy Codes:
152W00000X

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Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity. - Bioorganic & medicinal chemistry letters
In this Letter, the synthesis and the evaluation of the cytotoxicity of new hemiasterlin analogues were reported. The indole moiety was replaced respectively by benzofurane, naphthalene and 4-bromobenzene groups. Most of these derivatives possess strong cytotoxic activity on two human tumour cell lines (KB and Hep-G2), and some analogues showed comparable cytotoxic activity to that observed for paclitaxel and ellipticine, against KB and Hep-G2 cancer cell lines.Copyright © 2014 Elsevier Ltd. All rights reserved.
Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety. - Bioorganic & medicinal chemistry letters
In this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine.Copyright © 2014 Elsevier Ltd. All rights reserved.

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