1150 E Sherman Blvd Suite 1125
Muskegon MI 49444
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License #: 4301065628
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Lubricin: a novel means to decrease bacterial adhesion and proliferation. - Journal of biomedical materials research. Part A
This study investigated the ability of lubricin (LUB) to prevent bacterial attachment and proliferation on model tissue culture polystyrene surfaces. The findings from this study indicated that LUB was able to reduce the attachment and growth of Staphylococcus aureus on tissue culture polystyrene over the course of 24 h by approximately 13.9% compared to a phosphate buffered saline (PBS)-soaked control. LUB also increased S. aureus lag time (the period of time between the introduction of bacteria to a new environment and their exponential growth) by approximately 27% compared to a PBS-soaked control. This study also indicated that vitronectin (VTN), a protein homologous to LUB, reduced bacterial S. aureus adhesion and growth on tissue culture polystyrene by approximately 11% compared to a PBS-soaked control. VTN also increased the lag time of S. aureus by approximately 43%, compared to a PBS-soaked control. Bovine submaxillary mucin was studied because there are similarities between it and the center mucin-like domain of LUB. Results showed that the reduction of S. aureus and Staphylococcus epidermidis proliferation on mucin coated surfaces was not as substantial as that seen with LUB. In summary, this study provided the first evidence that LUB reduced the initial adhesion and growth of both S. aureus and S. epidermidis on a model surface to suppress biofilm formation. These reductions in initial bacteria adhesion and proliferation can be beneficial for medical implants and, although requiring more study, can lead to drastically improved patient outcomes.Â© 2014 Wiley Periodicals, Inc.
Mechanisms of enhanced osteoblast gene expression in the presence of hydroxyapatite coated iron oxide magnetic nanoparticles. - Nanotechnology
Hydroxyapatite (HA) coated iron oxide (Fe(3)O(4)) magnetic nanoparticles have been shown to enhance osteoblast (bone forming cells) proliferation and osteoblast differentiation into calcium depositing cells (through increased secretion of alkaline phosphatase, collagen and calcium deposition) compared to control samples without nanoparticles. Such nanoparticles are, thus, very promising for numerous orthopedic applications including magnetically directed osteoporosis treatment. The objective of the current study was to elucidate the mechanisms of the aforementioned improved osteoblast responses in the presence of HA coated Fe(3)O(4) nanoparticles. Results demonstrated large amounts of fibronectin (a protein known to increase osteoblast functions) adsorption on HA coated Fe(3)O(4) nanoparticles. Specifically, fibronectin adsorption almost doubled when HA coated Fe(3)O(4) nanoparticle concentrations increased from 12.5 to 100 Î¼g ml(-1), and from 12.5 to 200 Î¼g ml(-1), a four fold increase was observed. Results also showed greater osteoblast gene regulation (specifically, osteocalcin, type I collagen and cbfa-1) in the presence of HA coated Fe(3)O(4) nanoparticles. Collectively, these results provide a mechanism for the observed enhanced osteoblast functions in the presence of HA coated iron oxide nanoparticles, allowing their further investigation for a number of orthopedic applications.
Reflections on calling and careers in community psychology. - Journal of prevention & intervention in the community
The current essay discusses the narratives of five community psychologists from the perspective of a career "calling." Each of the essays highlight different components of a calling: employing deep discernment to know the right path for oneself; experiencing a calling to do one's work, an invitation to which we choose to respond; serving community; discovering your quintessential self or "genius"; and using your gifts for the common good. Moreover, the author discusses how the essays not only illustrate calling, but also the emergence of confidence and the subjective career.
Lifetime exposure to radiation from imaging investigations. - Canadian family physician MÃ©decin de famille canadien
To assess levels of radiation exposure from diagnostic imaging among family practice patients, the degree to which these levels exceed recommended levels, and whether radiation exposure level is associated with a diagnosis of cancer.Chart abstraction.Six practices in an academic family medicine centre and 1 family practice in the community.Two hundred fifty patients between the ages of 45 and 65 years with at least 20 years' information on their charts.All x-ray procedures, the dates they were performed, the amount of radiation exposure from each procedure based on standard charts, and whether diagnosis of any form of cancer was noted on the chart.Mean lifetime radiation exposure was 14.94 mSv. No patients had exceeded the lifetime occupational limit of 400 mSv; however, 4.4% of patients had exceeded the annual occupational exposure limit of 20 mSv at some point in their lives. Mean lifetime exposure of those with cancer was found to be significantly higher than exposure of those without cancer. This difference was due to the extra radiation exposure after the cancer was diagnosed; hence a causal relationship was not shown. Mean level of annual radiation exposure from diagnostic imaging has been slowly increasing since the 1960s.The current lifetime level of radiation to which patients are exposed by diagnostic imaging appears to be far below the maximum recommended level. Some patients do exceed the maximum recommended annual level, but this overexposure is generally warranted due to serious medical illness or injury, and the benefit outweighs the risk. We found no evidence of an association between these low levels of radiation and development of cancer.
Vaginectomy with pelvic herniorrhaphy for prolapse. - American journal of obstetrics and gynecology
The study was undertaken to report our experience with vaginectomy and pelvic herniorrhaphy for vaginal prolapse.This was an observational study of patients undergoing vaginectomy (n=41) or hysterovaginectomy (n=13) for stage III/IV vaginal prolapse. Morbidity was compared with cohorts who had undergone transvaginal repair of prolapse, by using the Mann-Whitney U test.Morbidity did not differ significantly (estimated blood loss) between the vaginectomy and hysterovaginectomy groups. There were no recurrent hernias (6-56 months). Operative time, estimated blood loss, and day of discharge were significantly greater for the posthysterectomy prolapse group compared with the vaginectomy group. Operative time was significantly greater for the uterovaginal prolapse group versus the hysterovaginectomy group.Vaginectomy with or without hysterectomy with pelvic herniorrhaphy is associated with a low rate of morbidity in a high-risk patient population. Hysterovaginectomy is not associated with a clinically significant difference in morbidity over vaginectomy alone. Vaginectomy with or without hysterectomy should be offered as a surgical option to selected patients with severe genital prolapse.
Morphology selection via geometric frustration in chiral filament bundles. - Nature materials
In assemblies, the geometric frustration of a locally preferred packing motif leads to anomalous behaviours, from self-limiting growth to defects in the ground state. Here, we demonstrate that geometric frustration selects the equilibrium morphology of cohesive bundles of chiral filaments, an assembly motif critical to a broad range of biological and synthetic nanomaterials. Frustration of inter-filament spacing leads to optimal shapes of self-twisting bundles that break the symmetries of packing and of the underlying inter-filament forces, paralleling a morphological instability in spherical two-dimensional crystals. Equilibrium bundle morphology is controlled by a parameter that characterizes the relative costs of filament bending and the straining of cohesive bonds between filaments. This parameter delineates the boundaries between stable, isotropic cylindrical bundles and anisotropic, twisted-tape bundles. We also show how the mechanical and interaction properties of constituent amyloid fibrils may be extracted from the mesoscale dimensions of the anisotropic bundles that they form.
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1150 E Sherman Blvd Suite 1125 Muskegon, MI 49444
1500 E Sherman Blvd
6401 Prairie St Suite 2100
1150 E Sherman Blvd Suite 1600
3535 Park St Ste 110