Dr. Maria  Alonso-Mahoney  Psyd image

Dr. Maria Alonso-Mahoney Psyd

12851 Nw 6Th St
Miami FL 33182
305 684-4627
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: PY 6143
NPI: 1790823342
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Bactericidal and synergistic activity of double-carbapenem regimen for infections caused by carbapenemase-producing Klebsiella pneumoniae. - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Available therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CR-Kp) are limited due to the high level of resistance to other antimicrobial classes including polymyxins. The double-carbapenem regimen has been recently considered a possible therapeutic strategy. In the present study, we evaluated the in-vitro bactericidal and synergistic activity of a double-carbapenem regimen consisting of ertapenem plus high dose of meropenem in a series of patients with healthcare associated CR-Kp infections in whom the use of colistin was not indicated because of potential nephrotoxicity and/or resistance. In-vitro synergy was evaluated using checkerboard and killing studies. A total of 15 subjects were included in the study, with sepsis, severe sepsis and septic shock found in 2 (13.3%), 5 (33.3%) and 1 (6.7%) patients, respectively. Overall, the clinical/microbiological response was 12/15 (80%). Synergy was observed in 11/14 (78.6%) isolates using checkerboard method whereas in killing studies 12/14 (85.7%) and 14/14 (100%) strains were synergistic and bactericidal at 24h at concentrations of 1xMIC MEM+1xMIC ERT and 2xMIC MEM+1xMIC ERT, respectively, with a significant decrease of log CFU/mL compared with other combinations (p<0.0001). The double-carbapenem regimen showed clinical and in-vitro effectiveness in patients with CR-Kp infections.Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Amino-terminal residues of ΔNp63, mutated in ectodermal dysplasia, are required for its transcriptional activity. - Biochemical and biophysical research communications
p63, a member of the p53 family, is a crucial transcription factor for epithelial development and skin homeostasis. Heterozygous mutations in TP63 gene have been associated with human ectodermal dysplasia disorders. Most of these TP63 mutations are missense mutations causing amino acidic substitutions at p63 DNA binding or SAM domains that reduce or abolish the transcriptional activity of mutants p63. A significant number of mutants, however, resides in part of the p63 protein that apparently do not affect DNA binding and/or transcriptional activity, such as the N-terminal domain. Here, we characterize five p63 mutations at the 5' end of TP63 gene aiming to understand the pathogenesis of the diseases and to uncover the role of ΔNp63α N-terminus residues in determining its transactivation potential.Copyright © 2015. Published by Elsevier Inc.
Zero-Flow Pressure Measured Immediately After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Provides the Best Invasive Index for Predicting the Extent of Myocardial Infarction at 6 Months: An OxAMI Study (Oxfor - JACC. Cardiovascular interventions
The aim of this study was to define which measure of microvascular best predicts the extent of left ventricular (LV) infarction.Microvascular injury after ST-segment elevation myocardial infarction (STEMI) is an important determinant of outcome. Several invasive measures of the microcirculation at primary percutaneous coronary intervention (PPCI) have been described. One such measure is zero-flow pressure (Pzf), the calculated pressure at which coronary flow would cease.In 34 STEMI patients, Pzf, hyperemic microvascular resistance (hMR), and index of microcirculatory resistance (IMR) were derived using thermodilution flow/pressure and Doppler flow/pressure wire assessment of the infarct-related artery following PPCI. The extent of infarction was determined by blinded late gadolinium enhancement on cardiac magnetic resonance at 6 months post-PPCI. Infarction of ≥24% total LV mass was used as a categorical cutoff in receiver-operating characteristic curve analysis.Pzf was superior to both hMR and IMR for predicting ≥24% infarction area under the curve: 0.94 for Pzf versus 0.74 for hMR (p = 0.04) and 0.54 for IMR (p = 0.003). Pzf ≥42 mm Hg was the optimal cutoff value, offering 100% sensitivity and 73% specificity. Patients with Pzf ≥42 mm Hg also had a lower salvage index (61.3 ± 8.1 vs. 44.4 ± 16.8, p = 0.006) and 6-month ejection fraction (62.4 ± 3.6 vs. 49.9 ± 9.6, p = 0.002). In addition, there were significant direct relationships between Pzf and troponin area under the curve (rho = 0.55, p = 0.002), final infarct mass (rho = 0.75, p < 0.0001), percentage of LV infarction and percent transmurality of infarction (rho = 0.77 and 0.74, respectively, p < 0.0001), and inverse relationships with myocardial salvage index (rho = -0.53, p = 0.01) and 6-month ejection fraction (rho = -0.73, p = 0.0001).Pzf measured at the time of PPCI is a better predictor of the extent of myocardial infarction than hMR or IMR. Pzf may provide important prognostic information at the time of PPCI and merits further investigation in clinical studies with relevant outcome measures.Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Evidence of intense chromosomal shuffling during conifer evolution. - Genome biology and evolution
While recent advances have been gained on genome evolution in angiosperm lineages, virtually nothing is known about karyotype evolution in the other group of seed plants, the gymnosperms. Here we used high density gene-based linkage mapping to compare the karyotype structure of two families of conifers (the most abundant group of gymnosperms) separated around 290 million years ago: Pinaceae and Cupressaceae. We propose for the first time a model based on the fusion of 20 ancestral chromosomal blocks that may have shaped the modern karyotpes of Pinaceae (with n=12) and Cupressaceae (with n=11). The considerable difference in modern genome organization between these two lineages contrasts strongly with the remarkable level of synteny already reported within the Pinaceae. It also suggests a convergent evolutionary mechanism of chromosomal block shuffling that has shaped the genomes of the spermatophytes.© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Biology of Hepatocellular Carcinoma. - Digestive diseases (Basel, Switzerland)
This chapter focuses on the identification of hepatocellular carcinoma (HCC) molecular signatures and the potentials of these signatures in prediction of HCC prognosis and driving of HCC therapeutic treatments. Progress in molecular profiling studies using DNA-microarray-based gene expression profiling has provided new insight about HCC pathogenesis, and gene signatures that can distinguish tumor subtypes assist clinical staging and predict patient outcomes. This provides the possibility to improve the stratification of HCC patients at a molecular level and, in the near future, will be potential in paving the way for tailored medicine in HCC patients.© 2015 S. Karger AG, Basel.
From gene to biorefinery: microbial β-etherases as promising biocatalysts for lignin valorization. - Frontiers in microbiology
The set-up of biorefineries for the valorization of lignocellulosic biomass will be core in the future to reach sustainability targets. In this area, biomass-degrading enzymes are attracting significant research interest for their potential in the production of chemicals and biofuels from renewable feedstock. Glutathione-dependent β-etherases are emerging enzymes for the biocatalytic depolymerization of lignin, a heterogeneous aromatic polymer abundant in nature. They selectively catalyze the reductive cleavage of β-O-4 aryl-ether bonds which account for 45-60% of linkages present in lignin. Hence, application of β-etherases in lignin depolymerization would enable a specific lignin breakdown, selectively yielding (valuable) low-molecular-mass aromatics. Albeit β-etherases have been biochemically known for decades, only very recently novel β-etherases have been identified and thoroughly characterized for lignin valorization, expanding the enzyme toolbox for efficient β-O-4 aryl-ether bond cleavage. Given their emerging importance and potential, this mini-review discusses recent developments in the field of β-etherase biocatalysis covering all aspects from enzyme identification to biocatalytic applications with real lignin samples.
Role of autophagy in the maintenance and function of cancer stem cells. - The International journal of developmental biology
Recent advances in experimental technologies and cancer models have made possible to demonstrate that the tumor is a dynamic system comprising heterogeneous populations of cancer cells organized in a hierarchical fashion with cancer stem cells (CSCs) at the apex. CSCs are immature cells characterized by self-renewal property and long-term repopulation potential. CSCs have been causally linked to cancer initiation, propagation, spreading, recurrence and relapse as well as to resistance to anticancer therapy. A growing body of evidence suggests that the function and physiology of CSCs may be influenced by genetic/epigenetic factors and tumor environment. In this context, macroautophagy is a lysosomal degradative process (herein referred to as autophagy) critical for the adaptive response to stress and the preservation of cellular and tissue homeostasis in all eukaryotes that may have a crucial role of in the origin, maintenance and invasiveness of CSCs. The activation of the autophagic machinery is also considered as an adaptive response of CSCs to perturbation of tumor microenvironment, caused for instance by anticancer therapy. Nevertheless, compelling preclinical and clinical evidence on the cytoprotective role of autophagy for CSCs is still missing. Here, we summarize the results on the contribution of autophagy in CSCs and how it impacts tumorigenesis and tumor progression. We also discuss the therapeutical potential of the modulation of autophagy as a means to eradicate CSCs.
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis. - Annals of the rheumatic diseases
Interferon (IFN) signature has been reported in definite systemic sclerosis (SSc) but it has not been characterised in early SSc (EaSSc). We aim at characterising IFN type I signature in SSc before overt skin fibrosis develops.The expression of 11 IFN type I inducible genes was tested in whole-blood samples from 30 healthy controls (HCs), 12 subjects with primary Raynaud's phenomenon (RP), 19 patients with EaSSc, 7 patients with definite SSc without cutaneous fibrosis, 21 limited cutaneous SSc and 10 diffuse cutaneous SSc subjects. The correlation between IFN activity in monocytes, B cell activating factor (BAFF) mRNA expression and type III procollagen N-terminal propeptide (PIIINP) serum levels was tested.In all the SSc groups, higher IFN scores were observed compared with HC. An IFN score ≥7.09 discriminated HCs from patients with SSc (sensitivity=0.7, specificity=0.88, area under receiving operating characteristic (AUROC)=0.82); the prevalence of an elevated IFN score was: HC=3.3%; RP=33.3%, EaSSc=78.9%, definite SSc=100%, limited cutaneous SSc=42.9%, diffuse cutaneous SSc=70.0%. In monocytes an IFN score ≥4.12 distinguished HCs from patients with fibrotic SSc (sensitivity=0.62, specificity=0.85, AUROC=0.76). Compared with IFN-negative subjects, IFN-positive subjects had higher monocyte BAFF mRNA levels (19.7±5.2 vs 15.20±4.0, p=2.1×10(-5)) and serum PIIINP levels (median=6.0 (IQR 5.4-8.9) vs median=3.9 (IQR 3.3-4.7), p=0.0004).An IFN type I signature is observed in patients with SSc from the earliest phases of the disease, even before overt skin fibrosis. The presence of IFN type I signature in monocytes is correlated with BAFF mRNA expression and serum PIIINP levels, supporting a contribution in the pathogenesis and progression of SSc.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to
High-density SNP assay development for genetic analysis in maritime pine (Pinus pinaster). - Molecular ecology resources
Maritime pine provides essential ecosystem services in the south-western Mediterranean basin, where it covers around 4 million ha. Its scattered distribution over a range of environmental conditions makes it an ideal forest tree species for studies of local adaptation and evolutionary responses to climatic change. Highly-multiplexed single-nucleotide polymorphism (SNP) genotyping arrays are increasingly used to study genetic variation in living organisms and for practical applications in plant and animal breeding and genetic resource conservation. We developed a 9k Illumina Infinium SNP array and genotyped maritime pine trees from i) a three-generation inbred (F2) pedigree, ii) the French breeding population, and iii) natural populations from Portugal and the French Atlantic coast. A large proportion of the exploitable SNPs (2,052 / 8,410, i.e. 24.4%) segregated in the mapping population and could be mapped, providing the densest ever gene-based linkage map for this species. Based on 5,016 SNPs, natural and breeding populations from the French gene pool exhibited similar level of genetic diversity. Population genetics and structure analyses based on 3,981 SNP markers common to the Portuguese and French gene pools revealed high levels of differentiation, leading to the identification of a set of highly differentiated SNPs that could be used for seed provenance certification. Finally, we discuss how the validated SNPs could facilitate the identification of ecologically and economically relevant genes in this species, improving our understanding of the demography and selective forces shaping its natural genetic diversity, and providing support for new breeding strategies. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
Uranium(III) Redox Chemistry Assisted by a Hemilabile Bis(phenolate) Cyclam Ligand: Uranium-Nitrogen Multiple Bond Formation Comprising a trans-{RN═U(VI)═NR}(2+) Complex. - Inorganic chemistry
A new monoiodide U(III) complex anchored on a hexadentate dianionic 1,4,8,11-tetraazacyclotetradecane-based bis(phenolate) ligand, [U(κ(6)-{((tBu2)ArO)2Me2-cyclam})I] (1), was synthesized from the reaction of [UI3(THF)4] (THF = tetrahydrofuran) and the respective potassium salt K2((tBu2)ArO)2Me2-cyclam and structurally characterized. Reactivity of 1 toward one-, two-, and four-electron oxidants was studied to explore the reductive chemistry of this new U(III) complex. Complex 1 reacts with one-electron oxidizers, such as iodine and TlBPh4, to form the seven-coordinate cationic uranium(IV) complexes [U(κ(6)-{((tBu2)ArO)2Me2-cyclam})I][X] (X = I (2-I), BPh4 (2-BPh4)). The new uranium(III) complex reacts with inorganic azides to yield the pseudohalide uranium(IV) complex [U(κ(6)-{((tBu2)ArO)2Me2-cyclam})(N3)2] (4) and the nitride-bridged diuranium(IV/IV) complex [(κ(4)-{((tBu2)ArO)2Me2-cyclam})(N3)U(μ-N)U(κ(5)-{((tBu2)ArO)2Me2-cyclam})] (5). Two equivalents of [U(κ(6)-{((tBu2)ArO)2Me2-cyclam})I] (1) effect the four-electron reduction of 1 equiv of PhN═NPh to form the bis(imido) complex [U(κ(4)-{((tBu2)ArO)2Me2-cyclam})(NPh)2] (6) and the U(IV) species 2-I. Moreover, the hemilability of the hexadentate ancillary ligand ((tBu2)ArO)2Me2-cyclam(2-) allows to perform the reductive cleavage of azobenzene with an unprecedented formation of a trans-bis(imido) complex. The complexes were characterized by NMR spectroscopy, and all the new uranium complexes were structurally authenticated by single-crystal X-ray diffraction.

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