Dr. Charles  Schmidt  Dc image

Dr. Charles Schmidt Dc

3395 Bouldercrest Rd
Ellenwood GA 30294
404 413-3280
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 005176
NPI: 1780794859
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Stepping into the sunshine. - Nature biotechnology
Is the imminent release of the database of industry's 'gifts' to doctors cause for concern or celebration? Charles Schmidt investigates.
Multiscaffold DNA origami nanoparticle waveguides. - Nano letters
DNA origami templated self-assembly has shown its potential in creating rationally designed nanophotonic devices in a parallel and repeatable manner. In this investigation, we employ a multiscaffold DNA origami approach to fabricate linear waveguides of 10 nm diameter gold nanoparticles. This approach provides independent control over nanoparticle separation and spatial arrangement. The waveguides were characterized using atomic force microscopy and far-field polarization spectroscopy. This work provides a path toward large-scale plasmonic circuitry.
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. - Structure (London, England : 1993)
Mixed lineage leukemia (MLL) fusion proteins cause oncogenic transformation of hematopoietic cells by constitutive recruitment of elongation factors to HOX promoters, resulting in overexpression of target genes. The structural basis of transactivation by MLL fusion partners remains undetermined. We show that the ANC1 homology domain (AHD) of AF9, one of the most common MLL translocation partners, is intrinsically disordered and recruits multiple transcription factors through coupled folding and binding. We determined the structure of the AF9 AHD in complex with the elongation factor AF4 and show that aliphatic residues, which are conserved in each of the AF9 binding partners, form an integral part of the hydrophobic core of the complex. Nuclear magnetic resonance relaxation measurements show that AF9 retains significant dynamic behavior which may facilitate exchange between disordered partners. We propose that AF9 functions as a signaling hub that regulates transcription through dynamic recruitment of cofactors in normal hematopoiesis and in acute leukemia.Copyright © 2013 Elsevier Ltd. All rights reserved.
Salmon as transport vectors for mercury. - Environmental science & technology
Some of the mercury adult salmon import to freshwater systems from the ocean goes back out to sea again with their offspring.
Chlorine inactivation of coliphage MS2 on strawberries by industrial-scale water washing units. - Journal of water and health
Fruits and vegetables (produce) intended for minimal processing are often rinsed or washed in water. Chlorine and other sanitizers are used during washing to inactivate produce spoilage microbes, but such procedures may also inactivate pathogens epidemiologically linked to produce, such as hepatitis A virus (HAV). However, no information exists on the efficacy of chlorinated wash water to inactivate HAV and other viruses on produce in actual practice, because of obvious safety concerns. In contrast, coliphage MS2 (a bacterial virus) is commonly used as a surrogate for some pathogenic viruses and may be safely used in field studies. In the present investigation, strawberries seeded with MS2 were passed through industrial-scale water washing units operated with or without added sodium hypochlorite. MS2 on strawberries was inactivated by 68%, 92% and 96% at free chlorine (FC) concentrations of < or = 2, 20 and 200 ppm in wash water, respectively. MS2 was detected in wash water containing < or = 2 ppm FC in one trial, but was not detected in water containing 20 or 200 ppm FC. The presence and absence of MS2 in wash water containing various levels of FC highlight the importance of controlling sanitizer levels to prevent viral cross contamination of strawberries.
Chlorine disinfection of produce to inactivate hepatitis A virus and coliphage MS2. - International journal of food microbiology
Disinfection of produce is principally used to inactivate spoilage microbes and may also reduce the risk of consumer exposure to enteric pathogens. However, the rate and extent of enteric virus inactivation by free chlorine on produce has not been adequately characterized. Experiments were performed to determine the kinetics of free chlorine inactivation of hepatitis A virus (HAV) and the indicator virus coliphage MS2 on strawberries (SBs), cherry tomatoes (CTs), and head lettuce (HL). The oxidant demand of these produce items also was determined. When produce items were exposed to approximately 20 parts per million (ppm) solution of free chlorine for 5-10 min, HAV and MS2 were inactivated by 90-99% and in some cases virus inactivation was > or =99%. Exposure of strawberries to approximately 200 ppm free chlorine resulted in more rapid and extensive inactivation of both viruses. The produce items tested in this study exhibited a demand for chlorine which varied by produce type, and chlorine residuals declined over time. These results demonstrate the potential for chlorine to reduce the levels of infectious viruses on different produce types, but adequate contact time and chlorine residual are required to achieve maximum virus inactivation. The difference in chlorine demand between SBs, CTs, and HL suggests that varying disinfection practices are needed for the wide variety of processed fruits and vegetables. The inactivation kinetics of MS2 and HAV were similar, suggesting that MS2 and perhaps other similar bacterial viruses may be used as process indicators and surrogates for determining the disinfection efficacy of produce in the laboratory or in actual practice.
A change in the air: smoking bans gain momentum worldwide. - World hospitals and health services : the official journal of the International Hospital Federation
Since 2004 smoking bans in indoor spaces have gathered momentum and become accepted in many other countries. This article reviews the progress that has been made and looks at how this policy, which began in the developed world, is now shifting to the developing one.
Unfair trade: e-waste in Africa. - Environmental health perspectives
Africa is quickly becoming a destination for information technology in the form of tons of used computers, fax machines, cell phones, and other electronics. Although many of these machines can be repaired and resold, up to 75% of the electronics shipped to Africa is junk. This equipment, when dumped, may leach lead, mercury, and cadmium into the environment; when burned, it may release carcinogenic dioxins and polyaromatic hydrocarbons. In the United States, activists are working to limit the flow of e-waste to developing countries through international agreements and voluntary e-waste export reduction efforts.
Experimental demonstration of relativistic electron cooling. - Physical review letters
We report on an experimental demonstration of electron cooling of high-energy antiprotons circulating in a storage ring. In our experiments, electron cooling, a well-established method at low energies (<500 MeV/nucleon), was carried out in a new region of beam parameters, requiring a multi-MeV dc electron beam and an unusual beam transport line. In this Letter, we present the results of the longitudinal cooling force measurements and compare them with theoretical predictions.
Obtaining quantitative vapor emissions estimates of polychlorinated biphenyls and other semivolatile organic compounds from contaminated sites. - Environmental toxicology and chemistry / SETAC
Soils contaminated with polychlorinated biphenyls (PCBs) and other semivolatile organic compounds (SVOCs) represent a potentially major, ongoing source of these compounds to the environment, especially during warmer temperatures. A great deal of work has been devoted to understanding the mechanisms that govern the vaporization of SVOCs from soil, but to date, few quantitative estimates have been published regarding emissions from contaminated sites. The present paper describes methods for obtaining quantitative estimates of SVOCs from soils based on flux chamber measurements, modeling, and ambient air measurements. On wet (i.e., H2O) soils, SVOCs at very low chemical loading levels on the adsorption sites (the so-called critical chemical concentration, critical loading, or saturation concentration) will behave, for volatilization purposes, as the pure-liquid substance would. For one soil, the PCB critical concentration was determined to be 775 ppm (95% confidence interval, 5.40E+02). Flux chamber-measured emissions from two contaminated sites were used and compared to model estimated values. The results agree reasonably well and indicate that the modeling approach used provided a conservative upper bound on the emissions. These approaches can be used to develop emissions estimates for SVOC-contaminated sites and inputs to air dispersion models.

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