Dr. Jasminder  Kaur  Dds image

Dr. Jasminder Kaur Dds

68 Stafford St
Worcester MA 01603
920 381-1649
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 22241
NPI: 1770746968
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The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. - Respiratory physiology & neurobiology
The effect of morphine on breathing and ventilatory chemoreflexes in obstructive sleep apnea (OSA) is unknown. It has been assumed that acute morphine use may induce deeper respiratory depression in OSA but this has not been investigated. We evaluated awake ventilatory chemoreflexes and overnight polysomnography on 10 mild-moderate OSA patients before and after giving 30 mg oral controlled-release morphine. Morphine plasma concentrations were analysed. We found a 30-fold range of morphine plasma concentrations with the fixed dose of morphine, and a higher plasma morphine concentration was associated with a higher CO(2) recruitment threshold (VRT) (r=0.86, p=0.006) and an improvement in sleep time with Sp(O(2)) (T90) (r=-0.87, p=0.005) compared to the baseline. The improvement in T90 also significantly correlated with the increase of VRT (r=-0.79, r=0.02). In conclusion, in mild-to-moderate OSA patients, a single common dose of oral morphine may paradoxically improve OSA through modulating chemoreflexes. There is a large inter-individual variability in the responses, which may relate to individual morphine metabolism.Copyright © 2012 Elsevier B.V. All rights reserved.
Synthesis of biosurfactants and their advantages to microorganisms and mankind. - Advances in experimental medicine and biology
Biosurfactants are surface-active compounds synthesized by a wide variety of microorganisms. They are molecules that have both hydrophobic and hydrophilic domains and are capable of lowering the surface tension and the interfacial tension of the growth medium. Biosurfactants possess different chemical structures--lipopeptides, glycolipids, neutral lipids and fatty acids. They are nontoxic biomolecules that are biodegradable. Biosurfactants also exhibit strong emulsification of hydrophobic compounds and form stable emulsions. The low water solubility of these hydrophobic compounds limits their availability to microorganisms, which is a potential problem for bioremediation of contaminated sites. Microbially produced surfactants enhance the bioavailability of these hydrophobic compounds for bioremediation. Therefore, biosurfactant-enhanced solubility of pollutants has potential applications in bioremediation. Not only are the biosurfactants useful in a variety of industrial processes, they are also of vital importance to the microbes in adhesion, emulsification, bioavailability, desorption and defense strategy. These interesting facts are discussed in this chapter.

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