259 1St St
Mineola NY 11501
Medical School: Tufts University School Of Medicine - 1991
Accepts Medicare: Yes
Participates In eRX: No
Participates In PQRS: Yes
Participates In EHR: Yes
License #: 237265-1
Request Appointment Information
Awards & Recognitions
Dr. Song Yu is associated with these group practices
|HCPCS Code||Description||Average Price||Average Price
Allowed By Medicare
|HCPCS Code:76942||Description:Echo guide for biopsy||Average Price:$446.00||Average Price Allowed
|HCPCS Code:64448||Description:N block inj fem cont inf||Average Price:$160.00||Average Price Allowed
|HCPCS Code:00740||Description:Anesth upper gi visualize||Average Price:$254.67||Average Price Allowed
|HCPCS Code:01922||Description:Anesth cat or mri scan||Average Price:$240.13||Average Price Allowed
|HCPCS Code:00810||Description:Anesth low intestine scope||Average Price:$176.29||Average Price Allowed
HCPCS Code Definitions
- Injection, anesthetic agent; femoral nerve, continuous infusion by catheter (including catheter placement)
- Ultrasonic guidance for needle placement (eg, biopsy, aspiration, injection, localization device), imaging supervision and interpretation
Medical Malpractice Cases
Medical Board Sanctions
Cardiovascular Disease (Cardiology)
Cardiovascular Disease (Cardiology)
*These referrals represent the top 10 that Dr. Yu has made to other doctors
Ordered Polypyrrole Nanowire Arrays Grown on Carbon Cloth Substrate for High Performance Pseudocapacitor Electrode. - ACS applied materials & interfaces
Highly aligned nanoarchitecture arrays directly grown on conducting substrates open up a new direction to accelerate Faradic reactions for charge storage as well as address "dead volume" limitations for high performance pseudocapacitor electrodes. Here we reported the electrochemical fabrication of well-ordered polypyrrole (PPy) nanowire arrays (NWAs) on surfaces of carbon fibers in untreated carbon cloth to construct hierarchical structures constituted by the three-dimensional conductive carbon fiber skeleton and the atop well-ordered electroactive polymer nanowires. Morphologies, wetting behaviors and charge storage performances of the polymer were investigated by scanning electron microscope (SEM), transmission electron microscope (TEM), contact angle (CA), cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy (EIS). The well-ordered PPy NWAs electrode exhibited a high specific capacitance of 699 F/g at 1 A/g with excellent rate capability, 92.4% and 81.5% of its capacitance could be retained at 10 and 20 A/g, respectively. An extremely high energy density of 164.07 Wh/kg can be achieved by the PPy NWAs at the power density of 0.65 kW/kg. It also displayed a quite high energy density of 133.79 Wh/kg at a high power density of 13 kW/kg. The assembled symmetric supercapacitor (SSC) of PPy NWAs//PPy NWAs also exhibited excellent rate capability, only 19% of its energy density decreased when the power density increased 20 times from 0.65 to 13 kW/kg.
Highly sensitive and selective detection of phosphate using novel highly photoluminescent water-soluble Mn-doped ZnTe/ZnSe quantum dots. - Talanta
Herein, the facile method with high selectivity for phosphate ion (Pi) sensing using novel Type-II core/shell Mn: ZnTe/ZnSe quantum dots (QDs) was reported. This was the first time that Mn: ZnTe/ZnSe QDs with highlighted optical properties were used for sensing. The water-soluble Mn: ZnTe/ZnSe QDs with a high quantum yield of 7% were synthesized by aqueous synthetic method. Compared with traditional ZnSe QDs or Mn: ZnSe QDs, the smaller effective band gap, longer wavelength and lower ionization potential (high valence band edge) for effective hole localization made Type-II core/shell Mn: ZnTe/ZnSe QDs to be stable and had high photoluminescence (PL). Only Mg(2+) was found to be able to enhance Mn: ZnTe/ZnSe QDs PL selectively. The mechanism of fluorescence enhancement was attributed to the passivated surface nonradiative relaxation centers of Mn: ZnTe/ZnSe QDs. In the presence of Pi anion, the PL intensity got quenched due to the aggregation species of QDs via electrostatic attraction between Pi and Mg(2+) on the surface of Mn: ZnTe/ZnSe QDs. Therefore, the quenching effect can be used to detect Pi selectively. The PL was observed to be linearly proportional to the Pi analyte concentration in the range from 0.67 to 50.0Î¼mol/L, with a detection limit of 0.2Î¼mol/L (S/N=3). The novel "on-off" fluorescence nanosensor for Pi detection was sensitive and convenient in the real analysis application. The reported analytical method of Mn: ZnTe/ZnSe QDs is highly sensitive and selective, which can corroborate the extension of its usages in chemo/ biosensing and bioimaging.Copyright Â© 2015 Elsevier B.V. All rights reserved.
miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. - Biology of reproduction
In mammals, follicular atresia can be partially triggered by granulosa cell apoptosis. However, very little is known about the functions of miRNAs in granulosa cell apoptosis. We previously reported that hsa-mir-23a (miR-23a) and hsa-mir-27a (miR-27a) were highly expressed in the plasma of patients with premature ovarian failure, but the action of these two miRNAs in follicular development was unclear. In this study, we explored the roles of miR-23a and miR-27a in the granulosa cells of women undergoing in vitro fertilization/embryo transfer. Using Hoechst staining, we found that miR-23a and miR-27a promoted apoptosis in human granulosa cells. In addition, the Western blotting results suggested that the miR-23a/miR-27a-mediated apoptosis occurred via the FasL-Fas pathway. Based on the results of a luciferase-reporter assay and quantitative RT-PCR and Western blotting analyses, we found that SMAD5 is a target gene of both miR-23a and miR-27a. Furthermore, knocking down SMAD5 expression increased the rate of apoptosis, as well as the levels of Fas, FasL, cleaved caspase-8, and cleaved caspase-3 protein. Taken together, these data suggest that miR-23a and miR-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL-Fas pathway. These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be used for future clinical applications.Â© 2015 by the Society for the Study of Reproduction, Inc.
Evaluation of breviscapine on prevention of experimentally induced abdominal adhesions in rats. - American journal of surgery
Adhesion formation, which results from mechanical peritoneal damage, tissue ischemia, or the presence of foreign materials, is a complicated process. The formation of adhesions is associated with inflammatory response and extracellular matrix deposition in response to injury. Although the pathophysiology of adhesion formation is widely understood, an absolute solution to this problem does not exist yet. As a main component of Erigeron breviscapus, breviscapine has exhibited the ability of anti-inflammatory and antifibrosis on many diseases. The purpose of this study was to investigate the effect of breviscapine on the development of postoperative intra-abdominal adhesions in Wistar rats.Abdominal adhesions were induced by scraping the cecum in rats. Various dosages of breviscapine drugs were administered for 10Â days after surgery. On the 11th day after surgery, the levels of interleukin (IL) 18, IL-6, tumor necrosis factor Î± in blood serum and transforming growth factor Î²1 (TGF-Î²1), connective tissue growth factor, tissue plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI-1) in peritoneal fluid were determined by enzyme linked immunosorbent assay. The expression of Smad7 and TGF-Î²1 in rat cecum tissue was evaluated by Western blot analysis. Grades of intestinal adhesion were ranked by macroscopic observation.The intraperitoneal administration of breviscapine is effective on the prevention of the formation of postoperative adhesions in rats. Breviscapine decreased the levels of IL-18, IL-6, and tumor necrosis factor-Î± in blood serum and TGF-Î²1, connective tissue growth factor, PAI-1 in peritoneal fluid. But the levels of tPA and the ratio of tPA and PAI-1 in peritoneal fluid were increased. In addition, breviscapine significantly inhibited the expression of TGF-Î²1 and increased the level of Smad7 in the rat cecum tissue.These results suggested that intraperitoneal administration of breviscapine was effective in preventing intra-abdominal adhesion formation in rats. Breviscapine appears to have synergetic effects which could decrease fibrosis by inhibiting inflammation, upregulating peritoneal fibrinolytic activity and regulating the TGF and/or Smad signaling pathway. These data indicated a potential new therapeutic use of breviscapine on adhesion prevention.Copyright Â© 2015 Elsevier Inc. All rights reserved.
Comparative analysis of complete chloroplast genome sequences of two tropical trees Machilus yunnanensis and Machilus balansae in the family Lauraceae. - Frontiers in plant science
Machilus is a large (c. 100 sp.) genus of trees in the family Lauraceae, distributed in tropical and subtropical East Asia. Both molecular species identification and phylogenetic studies of this morphologically uniform genus have been constrained by insufficient variable sites among frequently used biomarkers. To better understand the mutation patterns in the chloroplast genome of Machilus, the complete plastomes of two species were sequenced. The plastomes of Machilus yunnanensis and M. balansae were 152, 622 and 152, 721 bp, respectively. Seven highly variable regions between the two Machilus species were identified and 297 mutation events, including one micro-inversion in the ccsA-ndhD region, 65 indels, and 231 substitutions, were accurately located. Thirty-six microsatellite sites were found for use in species identification and 95 single-nucleotide changes were identified in gene coding regions.
Ultraviolet Photodissociation Dynamics of the Allyl Radical via the BÌƒ(2)A1(3s), CÌƒ(2)B2(3py), and áº¼(2)B1(3px) Electronic Excited States. - The journal of physical chemistry. A
Ultraviolet (UV) photodissociation dynamics of jet-cooled allyl radical via the BÌƒ(2)A1(3s), CÌƒ(2)B2(3py), and áº¼(2)B1(3px) electronically excited states are studied at the photolysis wavelengths from 249 to 216 nm using high-n Rydberg atom time-of-flight (HRTOF) and resonance-enhanced multiphoton ionization (REMPI) techniques. The photofragment yield (PFY) spectra of the H atom products are measured using both allyl chloride and 1,5-hexadiene as precursors of the allyl radical and show a broad peak centered near 228 nm, whereas the previous UV absorption spectra of the allyl radical peak around 222 nm. This difference suggests that, in addition to the H + C3H4 product channel, another dissociation channel (likely CH3 + C2H2) becomes significant with increasing excitation energy. The product translational energy release of the H + C3H4 products is modest, with the P(ET) distributions peaking near 8.5 kcal/mol and the fraction of the average translational energy in the total excess energy, âŸ¨fTâŸ©, in the range 0.22-0.18 from 249 to 216 nm. The P(ET)'s are consistent with production of H + allene and H + propyne, as suggested by previous experimental and theoretical studies. The angular distributions of the H atom products are isotropic, with the anisotropy parameter Î² â‰ˆ 0. The H atom dissociation rate constant from the pump-probe study gives a lower limit of 1 Ã— 10(8)/s. The dissociation mechanism is consistent with unimolecular decomposition of the hot allyl radical on the ground electronic state after internal conversion of the electronically excited state.
Combination of amniotic epithelial cells with NDGA promotes the survival of transplanted AECs in spinal cord-injured rats. - Neurological research
Our previous research has shown that seeding amniotic epithelial cells (AECs) in chemically extracted acellular muscle scaffold (CEAMC) better promotes the functional recovery of spinal cord injury (SCI) than scaffold alone. However, the massive death of transplanted cells, which is related to early inflammatory response, is still a problem in cell therapy. Our previous study proved that nordihydroguaiaretic acid (NDGA) inhibits inflammation after SCI. In this study, we tested a strategy of combining the early administration of NDGA and the transplantation of AEC-seeded CEAMC to treat SCI. The results showed that simply increasing the number of surviving AECs had no significant benefits in SCI therapy, but NDGA administration ameliorated transplanted AEC survival demonstrating the potential value of NDGA in the cellular transplantation treatment of SCI.
Whole-brain radiation fails to boost intracerebral gefitinib concentration in patients with brain metastatic non-small cell lung cancer: a self-controlled, pilot study. - Cancer chemotherapy and pharmacology
Whole-brain radiation therapy (WBRT) is generally considered as an efficient strategy to improve blood-brain barrier (BBB) permeability by damaging BBB structure and is therefore, used as a promising pretreatment of chemotherapy. However, the impact of radiotherapy on leaky BBB is still controversial for the reason that BBB of metastatic brain tumor lesion had been breached by tumor metastasizing. Herein, we conducted a self-controlled study to evaluate the effect of WBRT on the permeability of BBB in non-small cell lung cancer (NSCLC) patients with brain metastases (BM).A prospective self-controlled research was performed. Radiation-naive NSCLC patients with BM were enrolled and treated with gefitinib for 2Â weeks, and then concurrently combined with WBRT for 2Â weeks. Plasma and cerebrospinal fluid (CSF) before and after WBRT were collected on day 15 and 29 after the initiation of gefitinib treatment. The concentrations of gefitinib in these samples were measured by HPLC.Three patients were enrolled and evaluated. The concentrations of gefitinib in plasma and CSF pre-WBRT were comparable to those of post-WBRT. Consequently, no significant change was noted in the CSF-to-plasma ratios of gefitinib before and after WBRT (2.79Â Â±Â 1.47 vs. 2.35Â Â±Â 1.74Â %, pÂ =Â 0.123).The WBRT may not affect the BBB permeability by determining the concentration of gefitinib in NSCLC patients with BM.
Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function. - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
The causative factors of the vaginitis are not fully understood yet. Epithelial barrier dysfunction plays a critical role in the pathogenesis of vaginitis. This study aims to investigate the role of prolactin (PRL) in the causing the vaginal epithelial barrier dysfunction.Adult rats were treated with water-avoid-stress. The serum levels of PRL were determined by ELISA. T84 cell (T84 cells; a vaginal epithelial cell line) monolayers were prepared to be used assessing the epithelial barrier functions. The expression of occludin in T84 cells was assessed by Chromatin immunoprecipitation assay, methylation specifIc PCR, real time quantitative RT-PCR and Western blotting.The results showed that psychological stress markedly increased the serum levels of PRL in the rat vaginal epithelia. Exposure of T84 cells to PRL in the culture markedly increased the phosphorylation of STAT3 and suppressed the expression of occludin in the cells; the transepithelial electric resistance was decreased and the permeability to a macromolecular tracer was increased in the T84 monolayers, which was mimicked by blocking STAT3, or abolished by over expression of occludin in the epithelial cells.Psychological stress-derived PRL induces vaginal epithelial barrier dysfunction by inhibiting the expression of occludin.Â© 2015 S. Karger AG, Basel.
TRAF6-Mediated SM22Î± K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. - Circulation research
Vascular smooth muscle cell (VSMC) survival under stressful conditions is integral to promoting vascular repair, but facilitates plaque stability during the development of atherosclerosis. The cytoskeleton-associated smooth muscle (SM) 22Î± protein is involved in the regulation of VSMC phenotypes, whereas the pentose phosphate pathway plays an essential role in cell proliferation through the production of dihydronicotinamide adenine dinucleotide phosphate.To identify the relationship between dihydronicotinamide adenine dinucleotide phosphate production and SM22Î± activity in the development and progression of vascular diseases.We showed that the expression and activity of glucose-6-phosphate dehydrogenase (G6PD) are promoted in platelet-derived growth factor (PDGF)-BB-induced proliferative VSMCs. PDGF-BB induced G6PD membrane translocation and activation in an SM22Î± K21 ubiquitination-dependent manner. Specifically, the ubiquitinated SM22Î± interacted with G6PD and mediated G6PD membrane translocation. Furthermore, we found that tumor necrosis factor receptor-associated factor (TRAF) 6 mediated SM22Î± K21 ubiquitination in a K63-linked manner on PDGF-BB stimulation. Knockdown of TRAF6 decreased the membrane translocation and activity of G6PD, in parallel with reduced SM22Î± K21 ubiquitination. Elevated levels of activated G6PD consequent to PDGF-BB induction led to increased dihydronicotinamide adenine dinucleotide phosphate generation through stimulation of the pentose phosphate pathway, which enhanced VSMC viability and reduced apoptosis in vivo and in vitro via glutathione homeostasis.We provide evidence that TRAF6-induced SM22Î± ubiquitination maintains VSMC survival through increased G6PD activity and dihydronicotinamide adenine dinucleotide phosphate production. The TRAF6-SM22Î±-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.Â© 2015 American Heart Association, Inc.
Map & Directions
259 1St St Mineola, NY 11501
120 Mineola Blvd Suite 10 Lower Level
222 Station Plz N Suite 518