405 Londonderry Dr Suite 105
Waco TX 76712
Medical School: Jefferson Medical College Of Thomas Jefferson University - 1984
Accepts Medicare: Yes
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: G9284
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Awards & Recognitions
Dr. James Kavanagh is associated with these group practices
|HCPCS Code||Description||Average Price||Average Price
Allowed By Medicare
|HCPCS Code:00790||Description:Anesth surg upper abdomen||Average Price:$1,483.33||Average Price Allowed
|HCPCS Code:00300||Description:Anesth head/neck/ptrunk||Average Price:$1,147.06||Average Price Allowed
|HCPCS Code:00740||Description:Anesth upper gi visualize||Average Price:$778.26||Average Price Allowed
|HCPCS Code:01480||Description:Anesth lower leg bone surg||Average Price:$766.67||Average Price Allowed
|HCPCS Code:00810||Description:Anesth low intestine scope||Average Price:$745.45||Average Price Allowed
|HCPCS Code:01810||Description:Anesth lower arm surgery||Average Price:$662.50||Average Price Allowed
|HCPCS Code:00142||Description:Anesth lens surgery||Average Price:$637.84||Average Price Allowed
|HCPCS Code:00410||Description:Anesth correct heart rhythm||Average Price:$518.18||Average Price Allowed
|HCPCS Code:36620||Description:Insertion catheter artery||Average Price:$300.00||Average Price Allowed
Medical Malpractice Cases
Medical Board Sanctions
Cardiovascular Disease (Cardiology)
*These referrals represent the top 10 that Dr. Kavanagh has made to other doctors
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. - Journal of medicinal chemistry
The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced a 100-fold improvement in binding affinity, yielding lead compound 2 (KD = 15 Î¼M). Deconstruction of 2 into its component retrofragments allowed the group efficiency of structural motifs to be assessed, the identification of more LE scaffolds for optimization and highlighted binding affinity hotspots. Structure-guided addition of a metal-binding pharmacophore onto LE retrofragment scaffolds produced low nanomolar (KD = 15 nM) CYP121 ligands. Elaboration of these compounds to target binding hotspots in the distal active site afforded compounds with excellent selectivity against human drug-metabolizing P450s. Analysis of the factors governing ligand potency and selectivity using X-ray crystallography, UV-vis spectroscopy, and native mass spectrometry provides insight for subsequent drug development.
Reevaluation of the BRCA2 truncating allele c.9976Aâ€‰>â€‰T (p.Lys3326Ter) in a familial breast cancer context. - Scientific reports
The breast cancer predisposition gene, BRCA2, has a large number of genetic variants of unknown effect. The variant rs11571833, an Aâ€‰>â€‰T transversion in the final exon of the gene that leads to the creation of a stop codon 93 amino acids early (K3326*), is reported as a neutral polymorphism but there is some evidence to suggest an association with an increased risk of breast cancer. We assessed whether this variant was enriched in a cohort of breast cancer cases ascertained through familial cancer clinics compared to population-based non-cancer controls using a targeted sequencing approach. We identified the variant in 66/2634 (2.5%) cases and 33/1996 (1.65%) controls, indicating an enrichment in the breast cancer cases (pâ€‰=â€‰0.047, OR 1.53, 95% CI 1.00-2.34). This data is consistent with recent iCOGs data suggesting that this variant is not neutral with respect to breast cancer risk. rs11571833 may need to be included in SNP panels for evaluating breast cancer risk.
In situ production of human Î² defensin-3 in lager yeasts provides bactericidal activity against beer-spoiling bacteria under fermentation conditions. - Journal of applied microbiology
To examine the use of a natural antimicrobial peptide, human Î²-defensin-3 (HBD3), as a means of preventing spoilage from bacterial contamination in brewery fermentations and in bottled beer.A chemically synthesised HBD3 peptide was tested for bactericidal activity against common Gram-positive and Gram-negative beer-spoiling bacteria, including species of Lactobacillus, Pediococcus and Pectinatus. The peptide was effective at the Î¼mol l(-1) range in vitro, reducing bacterial counts by 95%. A gene construct encoding a secretable form of HBD3 was integrated into the genome of the lager yeast Saccharomyces pastorianus strain CMBS-33. The integrated gene was expressed under fermentation conditions and was secreted from the cell into the medium, but a significant amount remains associated with yeast cell surface. We demonstrate that under pilot-scale fermentation conditions, secreted HBD3 possesses bactericidal activity against beer-spoiling bacteria. Furthermore, when added to bottled beer, a synthetic form of HBD3 reduces the growth of beer-spoiling bacteria.Defensins provide prophylactic protection against beer-spoiling bacteria under brewing conditions and also in bottled beer.The results have direct application to the brewing industry where beer spoilage due to bacterial contamination continues to be a major problem in breweries around the world.Â© 2013 The Society for Applied Microbiology.
Reliability of segmental accelerations measured using a new wireless gait analysis system. - Journal of biomechanics
The purpose of this study was to determine the inter- and intra-examiner reliability, and stride-to-stride reliability, of an accelerometer-based gait analysis system which measured 3D accelerations of the upper and lower body during self-selected slow, preferred and fast walking speeds. Eight subjects attended two testing sessions in which accelerometers were attached to the head, neck, lower trunk, and right shank. In the initial testing session, two different examiners attached the accelerometers and performed the same testing procedures. A single examiner repeated the procedure in a subsequent testing session. All data were collected using a new wireless gait analysis system, which features near real-time data transmission via a Bluetooth network. Reliability for each testing condition (4 locations, 3 directions, 3 speeds) was quantified using a waveform similarity statistic known as the coefficient of multiple determination (CMD). CMD's ranged from 0.60 to 0.98 across all test conditions and were not significantly different for inter-examiner (0.86), intra-examiner (0.87), and stride-to-stride reliability (0.86). The highest repeatability for the effect of location, direction and walking speed were for the shank segment (0.94), the vertical direction (0.91) and the fast walking speed (0.91), respectively. Overall, these results indicate that a high degree of waveform repeatability was obtained using a new gait system under test-retest conditions involving single and dual examiners. Furthermore, differences in acceleration waveform repeatability associated with the reapplication of accelerometers were small in relation to normal motor variability.
Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana. - Nature
The plant Arabidopsis thaliana (Arabidopsis) has become an important model species for the study of many aspects of plant biology. The relatively small size of the nuclear genome and the availability of extensive physical maps of the five chromosomes provide a feasible basis for initiating sequencing of the five chromosomes. The YAC (yeast artificial chromosome)-based physical map of chromosome 4 was used to construct a sequence-ready map of cosmid and BAC (bacterial artificial chromosome) clones covering a 1.9-megabase (Mb) contiguous region, and the sequence of this region is reported here. Analysis of the sequence revealed an average gene density of one gene every 4.8 kilobases (kb), and 54% of the predicted genes had significant similarity to known genes. Other interesting features were found, such as the sequence of a disease-resistance gene locus, the distribution of retroelements, the frequent occurrence of clustered gene families, and the sequence of several classes of genes not previously encountered in plants.
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405 Londonderry Dr Suite 105 Waco, TX 76712
100 Hillcrest Medical Blvd Hospitalist/Trauma Office
405 Londonderry Dr Suite #311