811 Pendleton St #11
Greenville SC 29601
Medical School: Medical University Of South Carolina College Of Medicine - 1994
Accepts Medicare: Yes
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 20084
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Awards & Recognitions
Dr. Joshua Paul is associated with these group practices
|HCPCS Code||Description||Average Price||Average Price
Allowed By Medicare
|HCPCS Code:99214||Description:Office/outpatient visit est||Average Price:$140.68||Average Price Allowed
|HCPCS Code:85025||Description:Complete cbc w/auto diff wbc||Average Price:$46.00||Average Price Allowed
|HCPCS Code:81000||Description:Urinalysis nonauto w/scope||Average Price:$30.00||Average Price Allowed
|HCPCS Code:99213||Description:Office/outpatient visit est||Average Price:$85.00||Average Price Allowed
|HCPCS Code:36415||Description:Routine venipuncture||Average Price:$16.00||Average Price Allowed
HCPCS Code Definitions
- Office or other outpatient visit for the evaluation and management of an established patient, which requires at least 2 of these 3 key components: A detailed history; A detailed examination; Medical decision making of moderate complexity. Counseling and/or coordination of care with other physicians, other qualified health care professionals, or agencies are provided consistent with the nature of the problem(s) and the patient's and/or family's needs. Usually, the presenting problem(s) are of moderate to high severity. Typically, 25 minutes are spent face-to-face with the patient and/or family.
- Office or other outpatient visit for the evaluation and management of an established patient, which requires at least 2 of these 3 key components: An expanded problem focused history; An expanded problem focused examination; Medical decision making of low complexity. Counseling and coordination of care with other physicians, other qualified health care professionals, or agencies are provided consistent with the nature of the problem(s) and the patient's and/or family's needs. Usually, the presenting problem(s) are of low to moderate severity. Typically, 15 minutes are spent face-to-face with the patient and/or family.
Medical Malpractice Cases
Medical Board Sanctions
Cardiovascular Disease (Cardiology)
*These referrals represent the top 10 that Dr. Paul has made to other doctors
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. - Journal of immunology (Baltimore, Md. : 1950)
Differentiation of B cells into Ab-secreting cells induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and cell architecture. The transcription elongation factor eleven nineteen lysine-rich leukemia gene (ELL2) stimulates the processing of the secreted form of the IgH mRNA from the H chain gene. Mice (mus musculus) with the ELL2 gene floxed in either exon 1 or exon 3 were constructed and crossed to CD19-driven cre/CD19(+). The B cell-specific ELL2 conditional knockouts (cKOs; ell2(loxp/loxp) CD19(cre/+)) exhibit curtailed humoral responses both in 4-hydroxy-3-nitrophenyl acetyl-Ficoll and in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall responses were also diminished. The number of immature and recirculating B cells in the bone marrow is increased in the cKOs, whereas plasma cells in spleen are reduced relative to control animals. There are fewer IgG1 Ab-producing cells in the bone marrow of cKOs. LPS ex vivo-stimulated B220(lo)CD138(+) cells from ELL2-deficient mouse spleens are 4-fold less abundant than from control splenic B cells; have a paucity of secreted IgH; and have distended, abnormal-appearing endoplasmic reticulum. IRE1Î± is efficiently phosphorylated, but the amounts of Ig Îº, ATF6, BiP, Cyclin B2, OcaB (BOB1, Pou2af1), and XBP1 mRNAs, unspliced and spliced, are severely reduced in ELL2-deficient cells. ELL2 enhances the expression of BCMA (also known as Tnfrsf17), which is important for long-term survival. Transcription yields from the cyclin B2 and the canonical UPR promoter elements are upregulated by ELL2 cDNA. Thus, ELL2 is important for many aspects of Ab secretion, XBP1 expression, and the UPR.Copyright Â© 2014 by The American Association of Immunologists, Inc.
A sequentially Markov conditional sampling distribution for structured populations with migration and recombination. - Theoretical population biology
Conditional sampling distributions (CSDs), sometimes referred to as copying models, underlie numerous practical tools in population genomic analyses. Though an important application that has received much attention is the inference of population structure, the explicit exchange of migrants at specified rates has not hitherto been incorporated into the CSD in a principled framework. Recently, in the case of a single panmictic population, a sequentially Markov CSD has been developed as an accurate, efficient approximation to a principled CSD derived from the diffusion process dual to the coalescent with recombination. In this paper, the sequentially Markov CSD framework is extended to incorporate subdivided population structure, thus providing an efficiently computable CSD that admits a genealogical interpretation related to the structured coalescent with migration and recombination. As a concrete application, it is demonstrated empirically that the CSD developed here can be employed to yield accurate estimation of a wide range of migration rates.Copyright Â© 2012 Elsevier Inc. All rights reserved.
Australian population cohort study of newly arrived refugee children: how effective is predeparture measles and rubella vaccination? - The Pediatric infectious disease journal
Predeparture medical screening and measles-mumps-rubella vaccination are routinely given to refugee children before departure from most transit countries en route to Australia.The purpose of this study was to evaluate the effectiveness of this single measles-mumps-rubella vaccine and the reliability of its documentation. This is important in determining refugees' susceptibility to measles and rubella and the risk to the nonvaccinated community.We analyzed measles and rubella serology in a comprehensively screened population of newly arrived refugees. We reviewed seropositivity rates based on age, sex, country of departure and vaccine documentation.Of 164 children screened, 139 (84.8%) were immune to rubella; 143 (87.7%) to measles and 119 (73.0%) to both. There was no significant difference in immunity among those of different ages or those departing different continents. Immunity rates among those with documented measles-mumps-rubella tended to be higher: 91.1% for rubella, 89.1% for measles and 80.0% for both diseases, but this did not reach significance at the 5% level. There was a significant difference between males (65.9%) and females (81.3%) immune to both diseases (P = 0.042).This cohort demonstrated similar measles and rubella seropositivity rates to those of the Australian population, but lower rates than population seroconversion studies, which have been estimated at 95%. Males were less likely to be immune. Rates in those with documented vaccination approximated seroconversion studies. This confirms the appropriateness of current guidelines which suggest that immunization is not required in the face of documented prior vaccination, but is required without such documentation.
Blockwise HMM computation for large-scale population genomic inference. - Bioinformatics (Oxford, England)
A promising class of methods for large-scale population genomic inference use the conditional sampling distribution (CSD), which approximates the probability of sampling an individual with a particular DNA sequence, given that a collection of sequences from the population has already been observed. The CSD has a wide range of applications, including imputing missing sequence data, estimating recombination rates, inferring human colonization history and identifying tracts of distinct ancestry in admixed populations. Most well-used CSDs are based on hidden Markov models (HMMs). Although computationally efficient in principle, methods resulting from the common implementation of the relevant HMM techniques remain intractable for large genomic datasets.To address this issue, a set of algorithmic improvements for performing the exact HMM computation is introduced here, by exploiting the particular structure of the CSD and typical characteristics of genomic data. It is empirically demonstrated that these improvements result in a speedup of several orders of magnitude for large datasets and that the speedup continues to increase with the number of sequences. The optimized algorithms can be adopted in methods for various applications, including the ones mentioned above and make previously impracticable analyses possible.Software available upon request.Supplementary data are available at Bioinformatics email@example.com.
Genotype and SNP calling from next-generation sequencing data. - Nature reviews. Genetics
Meaningful analysis of next-generation sequencing (NGS) data, which are produced extensively by genetics and genomics studies, relies crucially on the accurate calling of SNPs and genotypes. Recently developed statistical methods both improve and quantify the considerable uncertainty associated with genotype calling, and will especially benefit the growing number of studies using low- to medium-coverage data. We review these methods and provide a guide for their use in NGS studies.
An accurate sequentially Markov conditional sampling distribution for the coalescent with recombination. - Genetics
The sequentially Markov coalescent is a simplified genealogical process that aims to capture the essential features of the full coalescent model with recombination, while being scalable in the number of loci. In this article, the sequentially Markov framework is applied to the conditional sampling distribution (CSD), which is at the core of many statistical tools for population genetic analyses. Briefly, the CSD describes the probability that an additionally sampled DNA sequence is of a certain type, given that a collection of sequences has already been observed. A hidden Markov model (HMM) formulation of the sequentially Markov CSD is developed here, yielding an algorithm with time complexity linear in both the number of loci and the number of haplotypes. This work provides a highly accurate, practical approximation to a recently introduced CSD derived from the diffusion process associated with the coalescent with recombination. It is empirically demonstrated that the improvement in accuracy of the new CSD over previously proposed HMM-based CSDs increases substantially with the number of loci. The framework presented here can be adopted in a wide range of applications in population genetics, including imputing missing sequence data, estimating recombination rates, and inferring human colonization history.
A principled approach to deriving approximate conditional sampling distributions in population genetics models with recombination. - Genetics
The multilocus conditional sampling distribution (CSD) describes the probability that an additionally sampled DNA sequence is of a certain type, given that a collection of sequences has already been observed. The CSD has a wide range of applications in both computational biology and population genomics analysis, including phasing genotype data into haplotype data, imputing missing data, estimating recombination rates, inferring local ancestry in admixed populations, and importance sampling of coalescent genealogies. Unfortunately, the true CSD under the coalescent with recombination is not known, so approximations, formulated as hidden Markov models, have been proposed in the past. These approximations have led to a number of useful statistical tools, but it is important to recognize that they were not derived from, though were certainly motivated by, principles underlying the coalescent process. The goal of this article is to develop a principled approach to derive improved CSDs directly from the underlying population genetics model. Our approach is based on the diffusion process approximation and the resulting mathematical expressions admit intuitive genealogical interpretations, which we utilize to introduce further approximations and make our method scalable in the number of loci. The general algorithm presented here applies to an arbitrary number of loci and an arbitrary finite-alleles recurrent mutation model. Empirical results are provided to demonstrate that our new CSDs are in general substantially more accurate than previously proposed approximations.
Pump-enhanced difference-frequency generation at 3.3 microm. - Applied optics
The demonstration of continuous wave intracavity difference-frequency generation in the mid-infrared (mid-IR) is presented. A cavity for pump laser enhancement is constructed around a periodically poled lithium niobate crystal, and the cavity length is locked to the frequency of the pump laser using the Pound-Drever-Hall technique, producing a gain of 12 in the resultant idler power compared to the single-pass case. A widely tunable single-mode 3.3 microm idler beam with a power of nearly 10 mW is available for direct absorption spectroscopy. The pump-enhancement method demonstrated here should be readily scalable to produce hundreds of milliwatts of mid-IR light by using higher power signal and pump lasers.
Topology-Scaling Identification of Layered Solids and Stable Exfoliated 2D Materials. - Physical review letters
The Materials Project crystal structure database has been searched for materials possessing layered motifs in their crystal structures using a topology-scaling algorithm. The algorithm identifies and measures the sizes of bonded atomic clusters in a structure's unit cell, and determines their scaling with cell size. The search yielded 826 stable layered materials that are considered as candidates for the formation of two-dimensional monolayers via exfoliation. Density-functional theory was used to calculate the exfoliation energy of each material and 680 monolayers emerge with exfoliation energies below those of already-existent two-dimensional materials. The crystal structures of these two-dimensional materials provide templates for future theoretical searches of stable two-dimensional materials. The optimized structures and other calculated data for all 826 monolayers are provided at our database (https://materialsweb.org).
A PROSPECTIVE, RANDOMIZED TRIAL COMPARING PLAIN GUT TO POLYGLACTIN 910 (VICRYL) SUTURES FOR SCLEROTOMY CLOSURE AFTER 23-GAUGE PARS PLANA VITRECTOMY. - Retina (Philadelphia, Pa.)
To report a prospective, randomized comparative study assessing clinical outcomes of plain gut versus polyglactin 910 (PG910) sutures for sclerotomy closure after 23-gauge pars plana vitrectomy.A single-masked, randomized, prospective study was undertaken with 49 eyes of 49 patients undergoing 23-gauge pars plana vitrectomy randomized to sclerotomy closure with either plain gut suture, PG910 (Vicryl) suture or a combination of the two. Assessment was based on both a postoperative pain scale and a standardized assessment of scleral inflammation at each suture site.No wound leakage was noted postoperatively in any patient. Across all groups, scleral inflammation was significantly higher at the PG910 suture sites compared with the plain gut suture sites at both the 1-week (P = 0.04) and 1-month postoperative visits (P < 0.001). Patients with PG910 sutures reported greater pain at the 1-month postoperative visit than those with plain gut sutures (P = 0.018).This prospective study suggests improved tolerability and reduced inflammation using plain gut suture compared with an 8-0 PG910 suture to close 23-gauge sclerotomies.
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811 Pendleton St #11 Greenville, SC 29601
317 St. Francis Drive Suite 125
317 Saint Francis Dr Ste 120
124 Mallard Street Greenville Mental Health Center
3 Saint Francis Dr Suite 300
3 Saint Francis Dr Suite 300