Docality.com Logo
 
Dr. Mary Ann Pirozzi-Bond  Dc image

Dr. Mary Ann Pirozzi-Bond Dc

732 W 9Th St Suite 102
San Pedro CA 90731
310 146-6815
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: DC25262
NPI: 1659514297
Taxonomy Codes:
111N00000X

Request Appointment Information

Awards & Recognitions

About Us

Practice Philosophy

Conditions

Medical Malpractice Cases

None Found

Medical Board Sanctions

None Found

Referrals

None Found

Publications

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. - Proceedings of the National Academy of Sciences of the United States of America
Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues. High-grade glioma (HGG), one of the most lethal human neoplasms, displays genetic modifications of Krebs cycle components as well as electron transport chain (ETC) alterations. Furthermore, the p53 tumor suppressor, which has emerged as a key regulator of mitochondrial respiration at the expense of glycolysis, is genetically inactivated in a large proportion of HGG cases. Therefore, it is becoming evident that genetic modifications can affect cell metabolism in HGG; however, it is currently unclear whether mitochondrial metabolism alterations could vice versa promote genomic instability as a mechanism for neoplastic transformation. Here, we show that, in neural progenitor/stem cells (NPCs), which can act as HGG cell of origin, inhibition of mitochondrial metabolism leads to p53 genetic inactivation. Impairment of respiration via inhibition of complex I or decreased mitochondrial DNA copy number leads to p53 genetic loss and a glycolytic switch. p53 genetic inactivation in ETC-impaired neural stem cells is caused by increased reactive oxygen species and associated oxidative DNA damage. ETC-impaired cells display a marked growth advantage in the presence or absence of oncogenic RAS, and form undifferentiated tumors when transplanted into the mouse brain. Finally, p53 mutations correlated with alterations in ETC subunit composition and activity in primary glioma-initiating neural stem cells. Together, these findings provide previously unidentified insights into the relationship between mitochondria, genomic stability, and tumor suppressive control, with implications for our understanding of brain cancer pathogenesis.

Map & Directions

732 W 9Th St Suite 102 San Pedro, CA 90731
View Directions In Google Maps

Nearby Doctors

593 W 6Th St
San Pedro, CA 90731
310 470-0202
1094 W 7Th St
San Pedro, CA 90731
310 334-4448
520 W 7Th St
San Pedro, CA 90731
310 325-5361
302 W 5Th St #101
San Pedro, CA 90731
310 325-5818
1294 W 6Th St Suite 204
San Pedro, CA 90731
310 325-5331
639 W 9Th St
San Pedro, CA 90731
310 311-1447
737 W 9Th St
San Pedro, CA 90731
310 335-5367
732 W Ninth Street Suite 200
San Pedro, CA 90731
310 485-5935
858 W 9Th St Ste 101
San Pedro, CA 90731
310 470-0887
571 W 7Th Street
San Pedro, CA 90731
310 311-1201