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Dr. Frank  Lagomarsino Iii Dc image

Dr. Frank Lagomarsino Iii Dc

5637 N Pershing Ave Suite F-1
Stockton CA 95207
209 528-8851
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: DC27930
NPI: 1659490647
Taxonomy Codes:
111N00000X

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Publications

Study of plasma-derived miRNAs mimic differences in Huntington's disease brain. - Movement disorders : official journal of the Movement Disorder Society
Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker in blood.This study was undertaken to examine candidate microRNAs in plasma to determine whether changes observed in HD brains are detectable in peripheral samples.Four microRNAs from 26 manifest Huntington's disease, four asymptomatic Huntington's disease gene carriers, and eight controls were quantified in plasma using reverse transcription quantitative polymerase chain reaction. Linear regression was used to assess microRNA levels across control, asymptomatic gene carriers, and manifest patients.miR-10b-5p (P = 0.0068) and miR-486-5p (P = 0.044) were elevated in Huntington's disease plasma. miR-10b-5p was decreased in asymptomatic gene carriers as compared with patients with Huntington's disease (P = 0.049), but no difference between asymptomatic gene carriers and healthy controls was observed (P = 0.24).These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility. © 2015 International Parkinson and Movement Disorder Society.© 2015 International Parkinson and Movement Disorder Society.

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5637 N Pershing Ave Suite F-1 Stockton, CA 95207
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