2566 Haymaker Rd
Monroeville PA 15146
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: MT199788
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Bilateral peripheral neural activity observed in vivo following unilateral nerve injury. - American journal of nuclear medicine and molecular imaging
Manganese-enhanced magnetic resonance imaging (MRI) is a surrogate method to measure calcium content in nervous system since manganese physiologically follows calcium. Manganese is detectable in MRI and therefore visualizes structures and cell populations that actively regulate calcium. Since calcium is actively recruited for the transmission of action potentials, our purpose is to validate manganese-enhanced MRI for detection of changes in lumbar nerves related to nociception. A neuropathic pain model was created by chronic constrictive injury of the left sciatic nerve of Sprague-Dawley rats. Behavioral measurements, using von Frey's tests, confirmed the presence of significant allodynia in the left hind limb of animals in the injured group. T1-weighted fast spin echo images were obtained of the lumbar cord and plexus of animals with injured left sciatic nerve and uninjured animals (control) scanned in a 7 Tesla magnet after intraperitoneal manganese chloride administration four weeks after surgery. Lumbar nerve roots and sciatic nerves in the injured group show increased normalized manganese-enhanced MRI signal, representing manganese enhancement, compared to the control group. In conclusion, animals with neuropathic pain in the left hind limb show increased manganese uptake in not only the injured sciatic nerve but also in the contralateral uninjured sciatic nerve on manganese-enhanced MRI in vivo. Although poorly understood, this finding corroborates ex vivo finding of bilateral nociceptive-related molecular changes in the nervous system of unilateral pain models.
A Comparative Study of FNAC and Histopathology of Thyroid Swellings. - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
Neck swelling is a common clinical presentation in ENT practice and it carries significant morbidity and even mortality if not managed properly. Thyroid swelling being the most common type we conducted a prospective study to assess the role of FNAC in diagnosing the nature of thyroid swelling and comparing its result with histopathology finding. It was observed that FNAC is a very reliable test having high sensitivity and specificity in thyroid swelling.
(18)F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain. - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
We demonstrated increased (18)F-FDG uptake in injured peripheral nerves in a model of neuropathic pain using small-animal PET/MRI.A neuropathic pain model in rats was created by spared-nerve injury of the left sciatic nerve. Sham-operated rats without nerve injury were used as a control. The presence of pain was confirmed by testing for allodynia. Sequential small-animal (18)F-FDG PET and MRI scans of the thighs were obtained and coregistered. Autoradiography was performed on harvested nerves and muscle.The group with spared-nerve injury showed the development of allodynia in the operated limb (P < 0.001). Increased (18)F-FDG uptake was observed on both PET/MRI (P < 0.001) and autoradiography (P < 0.005) in the operated nerve in this group. (18)F-FDG uptake in the nerves correlated well with allodynia (Ï = -0.59; P < 0.024).Animals with neuropathic pain show increased (18)F-FDG uptake in the affected nerve. Small-animal PET/MRI can be effectively used to localize (18)F-FDG uptake in peripheral nerves.
Parapharyngeal tumours: a review of 16 cases. - Journal of the Indian Medical Association
To study the clinical and histopathological characteristics along with the management and treatment outcome of parapharyngeal space tumours, a retrospective review analysis was undertaken in the department of otolaryngology and head and neck surgery, SCB Medical College and Hospital, Cuttack among 16 patients treated surgically. Of which, majority were benign and most common being Schwannoma. Parapharyngeal tumours are rare head and neck neoplasms. Their accurate diagnosis and management is challenging and requires a team approach. When the diagnosis is ambiguous, a complete surgical excision and histopathological examination should be the mode of approach for these rare tumours.
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2566 Haymaker Rd Monroeville, PA 15146
400 Oxford Dr Suite 102
3824 Northern Pike Ste 200
2550 Mosside Blvd Suite 105
4039 Monroeville Blvd Suite A
One Monroeville Ctr 3824 Northern Pike, Suite 800