Dr. Scott  Newcombe   image

Dr. Scott Newcombe

1875 California St Apt 6
San Francisco CA 94109
415 121-1232
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
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NPI: 1487935342
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Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). - Journal of medicinal chemistry
Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. We report here the discovery of a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. Compound 11i (AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development.
Age-related differences in foot structure and function. - Gait & posture
The aim of this study was to compare foot characteristics and plantar force and pressure patterns in young and older people. Fifty young (mean age 20.9+/-2.6 years) and 50 older (mean age 80.2+/-5.7 years) people without foot problems underwent tests of foot posture, range of motion, strength, sensation and deformity. Plantar force and pressure distribution during gait were evaluated using a floor-mounted resistive sensor mat system. Older participants exhibited flatter/more pronated feet, reduced range of motion of the ankle and 1st metatarsophalangeal joints, a higher prevalence of hallux valgus, toe deformities and toe plantarflexor weakness, and reduced plantar tactile sensitivity. Plantar pressure analysis revealed decreased magnitude of forces and pressures under the heel (-13% to 16%), metatarsophalangeal joints (-11% to 16%) and hallux (-19% to 25%), but greater relative contact time under the heel (+21%), midfoot (+14%) and metatarsophalangeal joints (+5% to 8%) in older participants. Multiple regression analysis revealed that these age-related differences could be largely explained by differences in step length and various foot characteristics, particularly foot posture and the severity of hallux valgus. These findings indicate that ageing is associated with significant changes in foot characteristics which contribute to altered plantar loading patterns during gait.

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1875 California St Apt 6 San Francisco, CA 94109
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