11123 Parkview Plaza Dr. Suite 202
Fort Wayne IN 46845
Medical School: Indiana University School Of Medicine - 1995
Accepts Medicare: Yes
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 01045652A
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Dr. Julie Platt is associated with these group practices
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*These referrals represent the top 10 that Dr. Platt has made to other doctors
Stable expression recognition abnormalities in unipolar depression. - Psychiatry research
Although abnormalities in emotion recognition during a depressed episode have frequently been reported in patients with depression, less is known about the stability of these abnormalities. To examine the stability of emotion recognition abnormalities, this longitudinal study assessed patients with unipolar depression on three separate occasions at 3-monthly intervals. Recognition of sad, angry, fearful, disgusted, happy and neutral facial expressions was assessed in a matching task and a labelling task. Patients performed as well as matched healthy controls on the matching task. On the labelling task, patients showed higher accuracy and higher response bias than controls for sad expressions only, which remained stable over a 6-month interval. Over the same period, symptom severity, as measured with the Beck Depression Inventory and the Hamilton Depression Rating Scale, decreased significantly in the patient group. Furthermore, labelling performance for sad expressions was not associated with symptom severity or with changes in severity over time. This stable bias for sad expressions might signal a vulnerability factor for depression, as proposed by cognitive theories of depression.Copyright Â© 2009 Elsevier Ltd. All rights reserved.
Core undergraduate psychiatry: what do non-specialists need to know? - Medical education
The purpose of this study is to define the most relevant topics for inclusion in an undergraduate psychiatric curriculum by asking non-psychiatrists what knowledge, skills and attitudes related to psychiatry they need in their day-to-day practice.A questionnaire study involving non-psychiatric doctors (based both in hospitals and general practice) was carried out using Delphi methodology in 2 waves. In the first wave, 408 doctors described the psychiatric competencies they required in their current posts. From this, a list of 101 psychiatric topics was generated. In the second wave, 867 doctors rated these topics according to the relevance of each topic to their practice.Depression, alcohol misuse and drug misuse were rated as most relevant. General practitioners found more topics relevant to their practice than did hospital doctors, and there were disparities in the relative importance that the 2 groups gave to topics.This study demonstrates a systematic method for developing core curricular undergraduate learning objectives in a specialty area by asking doctors outside that specialty to identify topics that are relevant to their practice. Similar methods could be used for a range of specialties other than psychiatry and could provide a rational and transparent means of developing a core curriculum for medical students, when combined with perspectives from other sources.
Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis. - Cancer genetics and cytogenetics
We have developed a simple analytical method that increases the efficiency of identifying mutant genes in cell lines after the inhibition of nonsense-mediated decay (NMD). The approach assumes that the spectra of mutant genes differ between cell lines of the same tumor origin. Thus, by analyzing more than one cell line in parallel and taking into account not only changes in mRNA levels after the inhibition of NMD, but also comparing mRNA levels between cell lines before the inhibition of NMD, the vast majority of false positives were eliminated from the analysis. In this study, we used Affymetrix oligonucleotide arrays to compare mRNA profiles of two prostate cancer cell lines, PC3 and LNCaP, before and after emetine treatment. As a result of our modified approach, from the 14,500 genes present on the array, 7 were identified as candidates from LNCaP cells and 1 was identified from PC3 cells. Sequence analysis of five of these candidate genes identified gene-inactivating mutations in four of them. Homozygous mutations were found in the synaptojanin 2 (SYNJ2) and the cleft lip and palate CLPTM1 genes. Two different heterozygous mutations in the Janus kinase 1 (JAK1) gene result in complete loss of the protein in several different prostate cancer cell lines.
Rectovaginal injury in a young child. A case report. - The Journal of reproductive medicine
Rectovaginal injuries in children, often the result of trauma, present as emergencies. Associated injuries may include ruptured urethra, bladder, vaginal vault or hollow viscus.A child younger than 2 years of age sustained a traumatic injury. Thorough examination required the use of skeletal radiography; computed tomography of the head, chest, abdomen and pelvis; and voiding cystourethrogram. Injury was limited to a fourth-degree perineal laceration. The wound was debrided and primarily closed in layered fashion. A diverting colostomy was performed to aid wound healing. Six weeks later, after wound resolution, colonic anastomosis was performed.Rectovaginal laceration in a child under the age of 13 requires thorough evaluation to identify the extent of traumatic injury. A diverting colostomy enhances wound healing.
Group B streptococcus: prevention of early-onset neonatal sepsis. - Obstetrical & gynecological survey
Group B streptococcus (GBS) was recognized as a major pathogen of neonatal disease in the 1970s. With a case-fatality rate of 5% to 20%, prevention of GBS neonatal disease has been an ongoing concern. The Centers for Disease Control and Prevention (CDC), and American College of Obstetricians and Gynecologists (ACOG) published guidelines for preventive strategies in 1996. These strategies, either a risk-based or a culture-based program, have been responsible for reduced incidence of GBS-newborn disease from 1.7 to 0.4 per 1,000 live births in the years 1993 to 1999. However, there has been considerable variability in practice patterns. Reanalysis now shows that a culture-based prevention strategy provides greater reduction in early-onset neonatal disease than a risk-based protocol. The CDC replacement guidelines of August 2002 recommend culture-based GBS prevention; the risk-based strategy is no longer supported. Continued efforts to eradicate GBS-newborn disease require an understanding of the pathogen, colonization, and transmission, GBS sampling and detection methods, and maternal therapy. Until a reliable vaccination against GBS is developed, prevention of neonatal GBS disease will rely upon intrapartum treatment of maternal carriers.Obstetricians & Gynecologists, Family PhysiciansAfter completion of this article, the reader will be able to define the pathogen, describe the methods of transmission and detection, and outline the current recommendations for maternal group B streptococcus therapy.
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11123 Parkview Plaza Dr. Suite 202 Fort Wayne, IN 46845
11108 Parkview Circle Dr
11123 Parkview Plaza Dr Suite 101
11104 Parkview Circle Dr Entrance 11, Suite 330
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11108 Parkview Circle Dr
11141 Parkview Plaza Dr Ste 110
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