390 E Longview St
Fayetteville AR 72703
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: E0548
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Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array. - Molecular biology of the cell
The polarity of microtubules (MTs) determines the motors for intracellular motility, with kinesins moving to plus ends and dynein to minus ends. In elongated cells of Ustilago maydis, dynein is thought to move early endosomes (EEs) toward the septum (retrograde), whereas kinesin-3 transports them to the growing cell tip (anterograde). Occasionally, EEs run up to 90 Î¼m in one direction. The underlying MT array consists of unipolar MTs at both cell ends and antipolar bundles in the middle region of the cell. Cytoplasmic MT-organizing centers, labeled with a Î³-tubulin ring complex protein, are distributed along the antipolar MTs but are absent from the unipolar regions. Dynein colocalizes with EEs for 10-20 Î¼m after they have left the cell tip. Inactivation of temperature-sensitive dynein abolishes EE motility within the unipolar MT array, whereas long-range motility is not impaired. In contrast, kinesin-3 is continuously present, and its inactivation stops long-range EE motility. This indicates that both motors participate in EE motility, with dynein transporting the organelles through the unipolar MT array near the cell ends, and kinesin-3 taking over at the beginning of the medial antipolar MT array. The cooperation of both motors mediates EE movements over the length of the entire cell.
Assessing cognitive impairment in Parkinson's disease: a comparison of two tower tasks. - Applied neuropsychology
This study examined whether two tower tasks-the Cambridge Automated Neuropsychological Test Battery "Stockings of Cambridge" (CANTAB-TOL) and the Delis-Kaplan Executive Function System (D-KEFS-TOH), are interchangeable for detecting cognitive deficits in Parkinson's disease (PD) patients. Forty PD patients who met the criteria for this study were assessed with both tasks. The relative contribution of working memory and inhibition was also examined. Relative to controls, PD patients were impaired on the CANTAB-TOL but not the D-KEFS-TOH. Regression analysis which showed that whereas performance on the CANTAB-TOL task was dependent on inhibition and spatial working memory, performance on the D-KEFS-TOH was dependent on spatial working memory only. Only 7% to 24% of the variance between the two tasks was shared. These findings suggest that these tower tasks from two well-established neuropsychological test batteries are not interchangeable.
Neuropsychiatric problems in Parkinson's disease: comparisons between self and caregiver report. - Aging & mental health
This study examined the level of agreement between caregiver and Parkinson's disease (PD) patient reports of neuropsychiatric problems.Forty-three patients and 43 informants who knew the patient well (caregivers) participated in the study. Caregivers rated patients' behaviour, as well as their own stress, using the Neuropsychiatric Inventory (NPI). Information from patients was obtained using commonly used scales (Beck Depression Inventory, Apathy Scale, Unified Parkinson's Disease Rating Scale and the Hamilton Anxiety Depression Scale). Both the patients and the caregivers also completed the Frontal Systems Behavior Scale, which assesses behaviours associated with apathy, disinhibition and executive dysfunction.The level of agreement between these self and caregiver reports was low, with only 45.8% agreement for depression, 45.0% for apathy, 28.6% for hallucinations, 26.9% for sleep problems and 6.7% for anxiety.Given this low level of agreement between self and other report, these two methods of assessment cannot be considered interchangeable.
Planning in Parkinson's disease: a matter of problem structure? - Neuropsychologia
Although the Tower of London (TOL) has been extensively used to assess planning ability in patients with Parkinson's disease (PD), the reported presence or extent of any planning deficits has been inconsistent. This may partly be due to the heterogeneity of the TOL tasks used and a failure to consider how structural problem parameters may affect task complexity. In the present study, planning in PD patients was assessed by systematically manipulating TOL problem structure. Results clearly disprove the identity assumption of problems with an equal number of minimum moves. Instead, substantial parts of planning performance were related to more subtle aspects of problem structure, such as subgoaling patterns and goal hierarchy. Planning in PD patients was not impaired in general but was affected when the information provided by the problem states was ambiguous in terms of the sequential order of subgoals, but not by increases in search depth.
A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson's disease patients without dementia. - Parkinsonism & related disorders
Neuropsychiatric problems are common in Parkinson's disease (PD) but there is little information regarding how they impact on quality of life. PD patients without dementia (49) were assessed for low mood/depression, fatigue, apathy, sleep problems and hallucinations. Measures of quality of life and motor function were also obtained. Over 77% of the patients reported symptoms consistent with one or more neuropsychiatric problems. Low mood/depression, anxiety and the presence of hallucinations predicted poorer quality of life after controlling for motor symptoms. Additional to the motor symptoms, we found that specific neuropsychiatric problems may impact on quality of life for PD patients.
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390 E Longview St Fayetteville, AR 72703
3215 N North Hills Blvd Suite B
3211 N Northhills Blvd Suite 110
1100 N College Ave Eye Clinic Veteran Health Care System Of The Oz
2460 N. Common Drive