2411 Fountain View Dr Ste. 200
Houston TX 77057
Medical School: Chicago College Of Medicine And Surgery - 1993
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: Yes
Participates In EHR: No
License #: K3294
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Awards & Recognitions
Dr. Frank Lastoczy is associated with these group practices
|HCPCS Code||Description||Average Price||Average Price
Allowed By Medicare
|HCPCS Code:01400||Description:Anesth knee joint surgery||Average Price:$576.43||Average Price Allowed
|HCPCS Code:00810||Description:Anesth low intestine scope||Average Price:$566.90||Average Price Allowed
|HCPCS Code:00740||Description:Anesth upper gi visualize||Average Price:$542.74||Average Price Allowed
|HCPCS Code:00142||Description:Anesth lens surgery||Average Price:$315.21||Average Price Allowed
|HCPCS Code:36620||Description:Insertion catheter artery||Average Price:$195.00||Average Price Allowed
Medical Malpractice Cases
Medical Board Sanctions
Cardiovascular Disease (Cardiology)
Physical Medicine And Rehabilitation
Cardiovascular Disease (Cardiology)
Cardiovascular Disease (Cardiology)
*These referrals represent the top 10 that Dr. Lastoczy has made to other doctors
Diagnosing Mitochondrial Disorder without Sophisticated Means. - Acta medica Iranica
Mitochondrial disorders (MIDs) require biochemical or genetic investigations for being diagnosed. In some cases, however, the diagnosis can be suspected upon the syndromic phenotype or upon clinical presentation and family history, as in the following case. The patient was a 74-year-old male admitted for worsening of pre-existing left-sided ptosis and ophthalmoparesis after a birthday party. The history was positive for arterial hypertension, hypertrophic cardiomyopathy with systolic dysfunction, diabetes-type 2, mild renal insufficiency, thyroiditis, and polyneuropathy. Instrumental investigations additionally revealed hepatopathy, hyperlipidemia, hyperuricemia, bifascicular block, white matter lesions, and subacute stroke. Systolic dysfunction resolved upon adequate cardiac treatment. On hospital day 11 the patient suddenly developed asystole. He was successfully resuscitated but died a few hours later from acute myocardial infarction. Surprisingly, a more extensive family history was positive for myopathy (patient, brother, daughter), neuropathy (patient), hypoacusis (patient), Parkinson syndrome (mother), spasticity (son), diabetes (patient, son), renal failure (patient), and generalized atherosclerosis (patient). The individual and family history was strongly suggestive of an MID. In conclusion, individual and family history may strongly suggest MID. Phenotypic variability may be high between family members affected by an MID. MID may be associated with an increasing atherosclerotic risk lastly resulting in coronary heart disease and death.
Social rhythm disrupting events increase the risk of recurrence among individuals with bipolar disorder. - Bipolar disorders
As outlined in the social zeitgeber hypothesis, social rhythm disrupting (SRD) life events begin a cascade of social and biological rhythm disruption that may lead to the onset of affective episodes in those vulnerable to bipolar disorder. Thus, the study of SRD events is particularly important in individuals with this chronic condition. The purpose of the current study was to evaluate (i) the extent to which SRD life events increased the risk of recurrence of a bipolar mood episode, and (ii) whether the social rhythm disruption associated with the event conferred an increased risk of recurrence, after accounting for the level of threat associated with the life event.We examined the effect of SRD events on recurrence during preventative treatment in a sample of 118 patients with bipolar disorder who achieved remission from an acute episode after receiving psychotherapy and pharmacotherapy. Life events were measured with the Bedford College Life Events and Difficulty Schedule and were rated for degree of SRD and threat.Time-dependent Cox proportional hazards models showed that having a higher SRD rating was significantly associated with an increased risk of recurrence, even when accounting for the threat effect of a life event and psychosocial treatment (hazard ratioÂ =Â 1.33, 95% confidence interval: 1.04-1.70, pÂ =Â 0.023). However, this finding fell below conventional levels of statistical significance when accounting for other covariates.Our findings lend partial support to the social zeitgeber hypothesis.Â© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Family caregivers of patients with frontotemporal dementia: An integrative review. - International journal of nursing studies
The purpose of this integrative review is to: (1) identify the characteristics of family caregivers of patients with frontotemporal dementia, (2) explore the impact of providing care on family caregivers' health and well-being, and (3) identify coping strategies used by family caregivers.Frontotemporal dementia is thought to be the second most common form of dementia after Alzheimer's disease. Family caregivers of patients with frontotemporal dementia face unique challenges due to its early onset, behavioral symptoms, and slow progression of decline. However, there is a dearth of research evaluating the health and wellbeing of family caregivers of patients with frontotemporal dementia.An integrative review was conducted using the Whittemore and Knafl methodology. An electronic search of the literature was conducted using four electronic databases: PubMed, Embase, CINAHL, and Web of Science. The Crowe Critical Appraisal tool was used to evaluate the quality of the selected articles.Findings of 11 articles informed this integrative review. Family caregivers of patients with frontotemporal dementia identify behavioral disturbances as most troubling. Spouses and female caregivers experience greater caregiver burden, distress, increased rates of depression, as well as decreased sleep related to behavior disturbances. Though less explored, providing care to those with behavioral disturbances may also impact caregiver physical health. Additionally, female caregivers are most likely to employ coping strategies, most commonly, adaptation and reframing. Effective interventions to reduce family caregiver burden are poorly understood but family caregivers suggest education and internet-based support groups are most helpful.Family caregivers of patients with frontotemporal dementia experience significant distress, which impacts their health and wellbeing. It is important for healthcare providers who care for patients with frontotemporal dementia to recognize the unique needs of family caregivers. Future research should focus on examining interventions and strategies to reduce caregiver burden.Copyright Â© 2015 Elsevier Ltd. All rights reserved.
Robust reconstitution of TB-specific polyfunctional CD4+ T-cell responses and rising systemic IL-6 in paradoxical TB-IRIS. - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
â€ƒThe immunopathogenesis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the association between pathogen-specific T-cell responses and development of paradoxical TB-IRIS on antiretroviral therapy (ART).â€ƒThis study was nested within a prospective cohort study of HIV-infected patients with active pulmonary TB and baseline CD4 counts â‰¤125 cells/Î¼l initiating ART. T-cell immune activation (CD38, HLA-DR, and PD-1 expression), phenotype, and polyfunctional pathogen-specific cellular immune responses prior to and 4 weeks after ART initiation were determined by flow cytometry. Patients with TB-IRIS were compared to non-IRIS controls using chi-square and rank sum tests and logistic regression.â€ƒTB-IRIS patients and controls had similar CD4 counts, levels of T-cell associated immune activation, frequencies of T-cell memory subsets and frequencies of IFN-Î³(+)/IL-2(+)/TNF-Î±(+) CD4(+) T-cells prior to ART initiation. After ART initiation, cellular immune activation and T-cell subsets also were similar in TB-IRIS patients and controls. In contrast, TB-IRIS patients had significantly greater early increases in the frequency of TB-specific polyfunctional IFN-Î³(+)/IL-2(+)/TNF-Î±(+) CD4(+) T-cells on ART (p=0.02); each quartile increase in the percentage of these cells was independently associated with a 2.8-fold increased risk of TB-IRIS (95% CI 1.1-7.5). In a secondary analysis, patients with TB-IRIS had rapid, concomitant increases in TB-specific adaptive immune responses and IL-6 levels, whereas controls with similarly rapid increases in cellular immune function had IL-6 levels that tended to decrease on ART.â€ƒRapid expansion of TB-specific polyfunctional CD4(+) T-cell responses, likely linked to increases in IL-6, is associated with development of paradoxical TB-IRIS.Â© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail email@example.com.
Assessing the Validity of Automated Webcrawlers as Data Collection Tools to Investigate Online Child Sexual Exploitation. - Sexual abuse : a journal of research and treatment
The distribution of child sexual exploitation (CE) material has been aided by the growth of the Internet. The graphic nature and prevalence of the material has made researching and combating difficult. Although used to study online CE distribution, automated data collection tools (e.g., webcrawlers) have yet to be shown effective at targeting only relevant data. Using CE-related image and keyword criteria, we compare networks starting from CE websites to those from similar non-CE sexuality websites and dissimilar sports websites. Our results provide evidence that (a) webcrawlers have the potential to provide valid CE data, if the appropriate criterion is selected; (b) CE distribution is still heavily image-based suggesting images as an effective criterion; (c) CE-seeded networks are more hub-based and differ from non-CE-seeded networks on several website characteristics. Recommendations for improvements to reliable criteria selection are discussed.Â© The Author(s) 2015.
A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring. - AIDS (London, England)
Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir (TFV), may be ideal for topical HIV preexposure prophylaxis because it has higher tissue and cell permeability than TFV, is not adversely impacted by seminal proteins, and its active metabolite, TFV-diphosphate (TFV-DP), has a long intracellular half-life. We engineered a TDF eluting polyurethane reservoir intravaginal ring (IVR) to provide near constant mucosal antiretroviral concentrations.A first-in-human randomized placebo-controlled trial was conducted to assess the safety and pharmacokinetics of the TDF IVR in healthy, sexually abstinent women (15 TDF and 15 placebo). Drug concentrations were measured in cervicovaginal fluid (CVF) obtained by swab, cervical tissue, plasma, and dried blood spots (DBS) over 14 days of continuous ring use.There were 43 total, 23 reproductive tract, and 8 product-related Grade 1 adverse events. Steady state CVF TFV concentrations were achieved proximal (vagina, ectocervix) and distal (introitus) to the TDF IVR one day after ring insertion. Median tissue TFV-DP concentrations 14 days after TDF IVR placement were 120â€Šfmol/mg (interquartile range 90, 550). CVF collected from the cervix one week and two weeks after TDF IVR insertion provided significant protection against ex vivo HIV challenge. Eleven of 14 (78%) participants had detectable TFV-DP DBS concentrations 14 days after TDF IVR placement, suggesting that DBS may provide a surrogate marker of adherence in future clinical trials.A TDF IVR is safe, well tolerated, and results in mucosal TFV concentrations that exceed those associated with HIV protection. The findings support further clinical evaluation of this TDF IVR.
TLR4 signaling on dendritic cells suppresses polymorphonuclear leukocytes CXCR2 expression and trafficking via IL-10 during intra-abdominal sepsis. - The Journal of infectious diseases
â€ƒToll-like receptor 4 (TLR4) is a critical receptor involved in the sensing of Gram negative bacterial infection. However, the roles of TLR4 in sepsis are cell type specific. Dendritic cells (DC) are known to play a central role in microbial detection, alerting the immune system to the presence of infection and coordinating adaptive immune response. The goal of this study was to investigate the impact of DC-specific TLR4 signaling on host defense against intra-abdominal polymicrobial sepsis.â€ƒC57BL/6, global Tlr4 knockout, cell specific knockout control, and CD11c-specific Tlr4(-/-) mice underwent cecal ligation and puncture (CLP).â€ƒSpecific deletion of TLR4 on DC in mice improved survival and enhanced bacterial clearance. Deletion of TLR4 on DC was associated with lower circulating IL10, higher polymorphonuclear leukocytes (PMN) accumulation in the peritoneal cavity, and higher expression of chemokine (C-X-C motif) receptor 2 (CXCR2) on PMN after CLP. In vitro studies of DC and neutrophil cocultures confirmed that TLR4-dependent secretion of IL-10 from DC regulated neutrophil CXCR2 expression.â€ƒOur data shed light on a previously unrecognized role for TLR4-signaling on DC in driving IL-10 secretion during sepsis, and through this pathway regulates PMN recruitment via suppression of CXCR2 expression.Â© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail firstname.lastname@example.org.
High-Throughput Analysis of Methylmalonic Acid in Serum, Plasma, and Urine by LC-MS/MS. Method for Analyzing Isomers Without Chromatographic Separation. - Methods in molecular biology (Clifton, N.J.)
Measurement of methylmalonic acid (MMA) plays an important role in the diagnosis of vitamin B12 deficiency. Vitamin B12 is an essential cofactor for the enzymatic carbon rearrangement of methylmalonyl-CoA (MMA-CoA) to succinyl-CoA (SA-CoA), and the lack of vitamin B12 leads to elevated concentrations of MMA. Presence of succinic acid (SA) complicates the analysis because mass spectra of MMA and SA are indistinguishable, when analyzed in negative ion mode and the peaks are difficult to resolve chromatographically. We developed a method for the selective analysis of MMA that exploits the significant difference in fragmentation patterns of di-butyl derivatives of the isomers MMA and SA in a tandem mass spectrometer when analyzed in positive ion mode. Tandem mass spectra of di-butyl derivatives of MMA and SA are very distinct; this allows selective analysis of MMA in the presence of SA. The instrumental analysis is performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in positive ion mode, which is, in combination with selective extraction of acidic compounds, is highly selective for organic acids with multiple carboxyl groups (dicarboxylic, tricarboxylic, etc.). In this method organic acids with a single carboxyl group are virtually undetectable in the mass spectrometer; the only organic acid, other than MMA, that is detected by this method is its isomer, SA. Quantitative measurement of MMA in this method is performed using a deconvolution algorithm, which mathematically resolves the signal corresponding to MMA and does not require chromatographic resolution of the MMA and SA peaks. Because of its high selectivity, the method utilizes isocratic chromatographic separation; reconditioning and re-equilibration of the chromatographic column between injections is unnecessary. The above features of the method allow high-throughput analysis of MMA with analysis cycle time of 1 min.
Dog walking among adolescents: Correlates and contribution to physical activity. - Preventive medicine
To assess the association of dog walking with adolescents' moderate-to-vigorous physical activity (MVPA) and BMI, and identify correlates of dog walking.Participants were 12-17year-olds (n=925) from the Baltimore, MD and Seattle, WA regions. Differences in accelerometer-assessed minutes/day of MVPA and self-reported BMI (percentile) were compared among adolescents (1) without a dog (n=441) and those with a dog who (2) did (â‰¥1days/week, n=300) or (3) did not (n=184) walk it. Correlates of (1) dog walking (any vs. none) among adolescents with dogs (n=484), and (2) days/week of dog walking among dog walkers (n=300) were investigated. Potential correlates included: demographic, psychosocial, home environment, perceived neighborhood environment, and objective neighborhood environment factors.52% of adolescents lived in a household with a dog, and 62% of those reported dog walking â‰¥1day/week. Dog walkers had 4-5 more minutes/day of MVPA than non-dog-walkers and non-dog-owners. BMI was not associated with dog walking or ownership. Among households with dogs, adolescents who lived in objectively walkable neighborhoods were 12% more likely to walk their dog than those in less walkable neighborhoods. Among dog walkers, having a multi-family home, college-educated parent, lower perceived traffic safety, higher street connectivity and less mixed use were related to more days/week of dog walking.Dog walkers had 7-8% more minutes/day of MVPA than non-dog walkers, and correlates of dog walking were found at multiple levels of influence. Results suggest multilevel interventions that include both environmental and psychosocial components to increase dog walking should be evaluated.Copyright Â© 2015. Published by Elsevier Inc.
Rapid eye movement sleep promotes cortical plasticity in the developing brain. - Science advances
Rapid eye movement sleep is maximal during early life, but its function in the developing brain is unknown. We investigated the role of rapid eye movement sleep in a canonical model of developmental plasticity in vivo (ocular dominance plasticity in the cat) induced by monocular deprivation. Preventing rapid eye movement sleep after monocular deprivation reduced ocular dominance plasticity and inhibited activation of a kinase critical for this plasticity (extracellular signal-regulated kinase). Chronic single-neuron recording in freely behaving cats further revealed that cortical activity during rapid eye movement sleep resembled activity present during monocular deprivation. This corresponded to times of maximal extracellular signal-regulated kinase activation. These findings indicate that rapid eye movement sleep promotes molecular and network adaptations that consolidate waking experience in the developing brain.
Map & Directions
2411 Fountain View Dr Ste. 200 Houston, TX 77057
2411 Fountain View Dr
2411 Fountain View Dr Suite 200
2411 Fountain View Dr Suite 200
6300 Richmond Ave Suite 202
2411 Fountain View Dr Ste. 200
2411 Fountain View Dr Suite 200