500 Upper Chesapeake Dr
Bel Air MD 21014
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Synthesis of akageneite (beta-FeOOH)/reduced graphene oxide nanocomposites for oxidative decomposition of 2-chlorophenol by Fenton-like reaction. - Journal of hazardous materials
In this work, the composite of reduced graphene oxide and akageneite (Ak/rGO) was synthesised by co-precipitating and reduction processes. The morphological and structural features of the synthesized composites (Ak/rGO) were characterized by XRD, SEM, BET, FTIR, Zeta potential and XPS. The results revealed that (1) beta-FeOOH was successfully loaded on the reduced graphene oxide (rGO); (2) the presence of strong interfacial interactions (FeOC bonds) between rGO and beta-FeOOH was observed; (3) the reduction of graphene oxide may be inhabited in the formation process of beta-FeOOH, producing rGO sheets rather than rGO sphere. In the heterogeneous Fenton-like reaction, the degradation rate constants of 2-chlorophenol (2-CP) increased 2-5 times after the addition of rGO probably due to the FeOC bond. The increase of the content of rGO could contribute to the removal of 2-CP, due to the synergy of catalysis and 2-CP adsorption towards Ak/rGO. In this study, the Ak/rGO composite has exhibited great potential and significant prospects for environmental application.Copyright Â© 2016 Elsevier B.V. All rights reserved.
A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria. - Chemical communications (Cambridge, England)
We have developed a new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism. The probe showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation. The probe targeted mitochondria with high selectivity and sensitivity toward H2S.
Effect of 6'-acetylpaeoniflorin on dinitrochlorobenzene-induced allergic contact dermatitis in BALB/c mice. - Immunologic research
Allergic contact dermatitis (ACD) is a classical experimental model of allergic inflammatory skin disease, which is a delayed-type hypersensitivity reaction that is mediated by hapten-specific T lymphocytes. The goal of this study was to investigate the pharmacokinetic profiles of 6'-acetylpaeoniflorin (6-AP) and the effect of 6-AP on the ACD model. 6-AP was synthesized from paeoniflorin (Pae) via acetylation, and the structure was confirmed. There were statistically significant differences in the pharmacokinetic parameters including t 1/2Î± , t 1/2Î² , AUC, MRT and C max among the animals that were orally administered Pae and 6-AP. An ACD model was induced using immunization with dinitrochlorobenzene (DNCB) in BALB/c mice. The mice were orally administered 6-AP (35, 70 and 140Â mg/kg/d), Pae (70Â mg/kg/d) and prednisone (Pre, 5Â mg/kg/d) from day 1 to day 7 after immunization. The results indicated that the topical application of DNCB to the skin provoked obvious inflammatory responses. 6-AP significantly inhibited ear swelling and decreased inflammatory cell infiltration and epidermal keratinization. Additionally, 6-AP observably alleviated the hyperplasia of red pulp and germinal center appearance, decreased the spleen index and inhibited splenocyte proliferation in the ACD model compared to that of Pae. Furthermore, the study indicated that 6-AP could increase the IL-10 level, while simultaneously reducing the IL-17 level in splenocytes. In summary, these results suggest that 6-AP has a significantly higher anti-inflammatory effect than Pae and that 6-AP might be a candidate for the treatment of allergic skin diseases.
[Three-dimension temporal and spatial dynamics of soil water for the artificial vegetation in the center of Taklimakan desert under saline water drip-irrigation]. - Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban
Three-dimension temporal and spatial dynamics of the soil water characteristics during four irrigating cycles of months from April to July for the artificial vegetation in the center of Taklimakan Desert under saline water drip-irrigation had been analyzed by timely measuring the soil water content in horizontal and vertical distances 60 cm and 120 cm away from the irrigating drips, respectively. Periodic spatial and temporal variations of soil water content were observed. When the precipitation effect was not considered, there were no significant differences in the characteristics of soil water among the irrigation intervals in different months, while discrepancies were obvious in the temporal and spatial changes of soil moisture content under the conditions of rainfall and non-rainfall. When it referred to the temporal changes of soil water, it was a little higher in April but a bit lower in July, and the soil water content in June was the highest among four months because some remarkable events of precipitation happened in this month. However, as a whole, the content of soil moisture was reduced as months (from April to July) went on and it took a decreasing tendency along with days (1-15 d) following a power function. Meanwhile, the characteristics of soil water content displayed three changeable stages in an irrigation interval. When it referred to the spatial distributions of soil water, the average content of soil moisture was reduced along with the horizontal distance following a linear regression function, and varied with double peaks along with the vertical distance. In addition, the spatial distribution characteristics of the soil water were not influenced by the factors of precipitation and irrigating time but the physical properties of soil.
Extrapolating microdomain Ca(2+) dynamics using BK channels as a Ca(2+) sensor. - Scientific reports
Ca(2+) ions play crucial roles in mediating physiological and pathophysiological processes, yet Ca(2+) dynamics local to the Ca(2+) source, either from influx via calcium permeable ion channels on plasmic membrane or release from internal Ca(2+) stores, is difficult to delineate. Large-conductance calcium-activated K(+) (BK-type) channels, abundantly distribute in excitable cells and often localize to the proximity of voltage-gated Ca(2+) channels (VGCCs), spatially enabling the coupling of the intracellular Ca(2+) signal to the channel gating to regulate membrane excitability and spike firing patterns. Here we utilized the sensitivity and dynamic range of BK to explore non-uniform Ca(2+) local transients in the microdomain of VGCCs. Accordingly, we applied flash photolysis of caged Ca(2+) to activate BK channels and determine their intrinsic sensitivity to Ca(2+). We found that uncaging Ca(2+) activated biphasic BK currents with fast and slow components (time constants being Ï„fâ€‰â‰ˆâ€‰0.2 ms and Ï„sâ€‰â‰ˆâ€‰10â€‰ms), which can be accounted for by biphasic Ca(2+) transients following light photolysis. We estimated the Ca(2+)-binding rate constant kb (â‰ˆ1.8â€‰Ã—â€‰10(8)â€‰M(-1)s(-1)) for mSlo1 and further developed a model in which BK channels act as a calcium sensor capable of quantitatively predicting local microdomain Ca(2+) transients in the vicinity of VGCCs during action potentials.
Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein. - Oncology letters
Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to integration with current therapeutic approaches. However, the mechanisms underlying the interaction between these two agents remain unclear. The present study assessed the cytotoxic effect of the HDACi, suberoylanilide hydroxamic acid (SAHA), in combination with the proteasome inhibitor, MG-132, in imatinib-sensitive K562 and imatinib-resistant K562G cells, and investigated the mechanism underlying this effect. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and protein expression levels were determined by western blotting. Reactive oxygen species (ROS) generation levels were observed under a fluorescence microscope The results indicated that SAHA and MG-132 act in a synergistic manner to induce cell death in K562 and K562G cells. This effect was associated with Bcr-Abl downregulation and the production of ROS. Notably, the ROS scavenger, N-acetyl-L-cysteine, almost fully reversed the cell death and Bcr-Abl downregulation that was induced by the combination of SAHA and MG-132. By contrast, the pan-caspase inhibitor, z-VAD-fmk, only partially reversed the cell death induced by these two drugs in CML cells. These results indicated that increased intracellular ROS levels are important in the induction of cell death and the downregulation of Bcr-Abl. In conclusion, the present results suggested that combined SAHA and MG-132 may be a promising treatment for CML.
[Determination of the contents of vitamin C and its derivatives in cosmetics by high performance liquid chromatography]. - Se pu = Chinese journal of chromatography / Zhongguo hua xue hui
A method has established for the detection of vitamin C (VC) and its derivatives (ascorbyl glucoside, AA-2G; magnesium ascorbyl phosphate, AA-2P; ascorbic acid ethyl ether, Only VCE) in cosmetics by high performance liquid chromatography (HPLC). Low fat cosmetic samples such as make-up water and lotion were extracted directly with 30 mL 0.02 mol/L potassium dihydrogen phosphate solution (pH 3.0). High fat cosmetic samples such as face cream and gel were well dispersed with 1.0 mL dichloromethane first, then extracted with 25 mL 0.02 mol/L potassium dihydrogen phosphate solution (pH 3.0). The sample solution was centrifuged with a speed of 12,000 r/min, then filtered through a 0.22 Î¼m syringe filter. The filtrate was analyzed on a column of YMC-Triart C18 (250 mm x 4.6 mm, 5 Î¼m) using 0.02 mol/L potassium dihydrogen phosphate solution (pH 3.0) and methanol as mobile phases with a flow rate of 1.0 mL/min. The temperature of the column was 25 Â°C and the detection wavelength was 250 nm. The standard working curves of the four analytes had good linear relationship (r2>0.9999). The detection limits of the four analytes were 0.04-0.08 g/kg (S/N=10). The recoveries were 95.6%-101.0% with the relative standard deviations of 0.62%-3.0% at the spiked levels of 0.25-5.0 g/kg. This method is a simple, rapid, exact and reliable for the determination of the contents of vitamin C and its derivatives in cosmetics.
Hydrogels: Edge-Hydroxylated Boron Nitride Nanosheets as an Effective Additive to Improve the Thermal Response of Hydrogels (Adv. Mater. 44/2015). - Advanced materials (Deerfield Beach, Fla.)
Upon flowing hot-water steam over hexagonal boron nitride (h-BN) bulk powder, efficient exfoliation and hydroxylation of the h-BN occur simultaneously. The edge-hydroxylation enables excellent dispersion of the nanosheets in water and also helps to maintain their high thermal conductivity along the h-BN plane. Used as an additive, the thermal response of a poly(N-isopropylacrylamide) (PNIPAM) hydrogel is dramatically improved, featuring faster shrinkage and dye release. This is described by Z. Huang and co-workers on page 7196.Â© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury. - Journal of neuroinflammation
Ficolin-mediated activation of the lectin pathway of complement contributes to the complement-independent inflammatory processes of traumatic brain injury. Lower serum ficolin-3 levels have been demonstrated to be highly associated with unfavorable outcome after ischemic stroke. This prospective observatory study was designed to investigate the relationships between serum ficolin-3 levels and injury severity and clinical outcomes after severe traumatic brain injury.Serum ficolin-3 levels of 128 patients and 128 healthy controls were measured by sandwich immunoassays. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3. Study endpoints included mortality at 1Â week and 6Â months and unfavorable outcome at 6Â months after head trauma. Injury severity was assessed by Glasgow Coma Scale score. Multivariate logistic models were structured to evaluate the relationships between serum ficolin-3 levels and study endpoints and injury severity.Compared with the healthy controls, serum ficolin-3 levels on admission were statistically decreased in patients with severe traumatic brain injury. Serum ficolin-3 levels were independently correlated with Glasgow Coma Scale scores. Ficolin-3 was also identified as an independent prognostic predictor for 1-week mortality, 6-month mortality, and 6-month unfavorable outcome. Under receiver operating characteristics curves, ficolin-3 has similar prognostic predictive values for all study endpoints compared with Glasgow Coma Scale scores.It was proposed that lower serum ficolin-3 levels, correlated with injury severity, had the potential to be the useful, complementary tool to predict short- or long-term clinical outcomes after severe traumatic brain injury.
Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report. - Experimental and therapeutic medicine
Nitrogen mustards are chemical agents that are similar to sulfur mustards, with similar toxicities. The present study describes a case of nitrogen mustard-induced acute respiratory failure and myelosuppression in a 33-year-old man. The patient, who was accidentally exposed to nitrogen mustard hydrochloride in a pharmaceutical factory, exhibited severe inhalation injury and respiratory symptoms. Laboratory tests revealed reduced white blood cell counts and lowered platelet levels during the first 6 days after the skin exposure to nitrogen mustard. Following treatment with mechanical ventilation, immunity-enhancing agents and nutritional supplements for 1 month, the patient successfully recovered and was released from hospital.
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500 Upper Chesapeake Dr Bel Air, MD 21014
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500 Upper Chesapeake Dr
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