Mmc - Dept. Of Anesthesiology 111 East 210Th Street
Bronx NY 10467
Medical School: Other - 1985
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: Yes
Participates In EHR: No
License #: 224293
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Dr. Jing Song is associated with these group practices
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*These referrals represent the top 10 that Dr. Song has made to other doctors
Human POLD1 modulates cell cycle progression and DNA damage repair. - BMC biochemistry
The activity of eukaryotic DNA polymerase delta (Pol Î´) plays an essential role in genome stability through its effects on DNA replication and repair. The p125 catalytic subunit of Pol Î´ is encoded by POLD1 gene in human cells. To clarify biological functions of POLD1, we investigated the effects of POLD1 overexpression or downregulation on cell proliferation, cell cycle progression, DNA synthesis and oxidative DNA damage induced by H2O2.HEK293 cells were transfected with POLD1 expression plasmid or shRNA, cell proliferation, cell cycle progression, and DNA synthesis in HEK293 cells were analyzed.HEK293 cells were transfected with POLD1 expression plasmid or shRNA. POLD1 downregulation by shRNA suppressed cell proliferation, cell cycle progression, and DNA synthesis in HEK293 cells. However, POLD1 overexpression had no significant effects on these processes. Finally, comet assay showed that POLD1 downregulation led to increased DNA damage.Our results suggest that human POLD1 plays important role in the regulation of cell cycle progression and DNA damage repair.
Application of Organophosphonic Acids by One-Step Supercritical CO2 on 1D and 2D Semiconductors: Towards Enhanced Electrical and Sensing Performances. - ACS applied materials & interfaces
Formation of dense monolayers with proven atmospheric stability using simple fabrication conditions remains a major challenge for potential applications such as (bio)sensors, solar cells, surfaces for growth of biological cells, and, also, molecular, organic and plastic electronics. Here, we demonstrate a single-step modification of organophosphonic acids (OPA) on 1D and 2D structures using supercritical carbon dioxide (SCCO2) as a processing medium, with high stability and significantly shorter processing times than those obtained by the conventional physisorption-chemisorption method (2.5 h vs. 48-60 h).The advantages of this approach in terms of stability and atmospheric resistivity are demonstrated on various 2D materials, such as Indium-Tin-Oxide (ITO) and 2D Si surfaces. The advantage of the reported approach on electronic and sensing devices is demonstrated by Si nanowire Field Effect Transistors (SiNW FETs), which have shown a few orders of magnitude higher electrical and sensing performances, compared with devices obtained by conventional approaches. The compatibility of the reported approach with various materials and its simple implementation with a single reactor makes it easily scalable for various applications.
Toxicity of Graphene Quantum Dots in Zebrafish Embryo. - Biomedical and environmental sciences : BES
To evaluate the bio-safety of graphene quantum dots (GQDs), we studied its effects on the embryonic development of zebrafish.In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 Î¼g/mL for 4-96 h post-fertilization (hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined.The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs (200 Î¼g/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 Î¼g/mL. The larval behavior testing (visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 Î¼g/mL showed hyperactivity while exposure to higher concentrations (25, 50, 100, and 200 Î¼g/mL) caused remarkable hypoactivity in the light-dark test.Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 Î¼g/mL.Copyright Â© 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
Sedentary Behavior as a Risk Factor for Physical Frailty Independent of Moderate Activity: Results From the Osteoarthritis Initiative. - American journal of public health
This prospective longitudinal study investigated the association between baseline objectively measured sedentary time and 2-year onset of physical frailty.We studied 1333 Osteoarthritis Initiative participants 55 to 83 years of age who were at risk for physical frailty, as assessed via low gait speed (<â€‰0.6 m per second) or inability to perform a single chair stand. Baseline sedentary time was assessed through accelerometer monitoring. Hazard ratios (HRs) for physical frailty onset were estimated with discrete survival methods that controlled for moderate physical activity, sociodemographic characteristics, baseline gait and chair stand functioning, and health factors.The incidence of physical frailty in this high-risk group was 20.7 per 1000 person-years. Greater baseline sedentary time (adjusted HRâ€‰=â€‰1.36 per sedentary hour; 95% confidence interval [CI]â€‰=â€‰1.02, 1.79) was significantly related to incident physical frailty after control for time spent in moderate-intensity activities and other covariates.Our prospective data demonstrated a strong relationship between daily sedentary time and development of physical frailty distinct from insufficient moderate activity. Interventions that promote reductions in sedentary behaviors in addition to increases in physical activity may help decrease physical frailty onset.
Layer-by-layer introduction of poly(phenylenevinylene) onto microspheres and probing the influence from the weak/strong polyanion spacer-layers. - Journal of colloid and interface science
The layer-by-layer (LBL) technique was employed for preparing fluorescent microspheres with a core-shell structure by the alternating adsorption of positively charged poly(p-phenylenevinylene) precursor (pre-PPV) and the polyanions onto polymer substrate spheres, followed by the thermal elimination to convert pre-PPV into fluorescent poly(p-phenylenevinylene) (PPV). Weak polyelectrolytes poly(acrylic acid) (PAA) (usually in a partly ionized form) and strong polyelectrolytes poly(sodium-p-styrenesulfonate) (PSS) were used as the anions to space the PPV layers and reduce the fluorescence self-quenching. Flow cytometry, combined with spectroscopy and microscopy, were used to study the structure and photophysical properties of the resulting microspheres. Optimization of the processing factors was carried out. PAA and PSS as weak and strong polyelectrolytes, respectively, displayed very different influence on the final emission of the spheres. Such difference was attributed to different inherent characteristics of PAA and PSS after detailed investigation in many aspects. In addition, the fluorescent spheres were found to have excellent photostability and thermal stability.Copyright Â© 2015 Elsevier Inc. All rights reserved.
Writing nanopatterns with electrochemical oxidation on redox responsive organometallic multilayers by AFM. - Nanoscale
Nanoelectrochemical patterning of redox responsive organometallic poly(ferrocenylsilane) (PFS) multilayers is demonstrated by electrochemical dip pen lithography (EDPN). Local electrochemical oxidation and Joule heating of PFS multilayers from the tip are considered as relevant mechanisms related to structure generation. The influence of applied bias potential, tip velocity, and multilayer thickness on the pattern height and width were investigated.
[Clinical trials for treatment of primary hyperlipidemia by using acupuncture in combination with Lipitor]. - Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji]
To observe the clinical effect of acupuncture therapy combined with Lipitor in the treatment of primary hyperlipidemia (spleen deficiency and food stagnation type).Sixty primary hyperlipidemia patients (spleen deficiency and food stagnation type) were equally randomized into medication group and acupuncture plus medication group. Patients of both groups were treated by oral administration of Lipitor (20 mg/tablet, one tablet per day) for 6 weeks. Manual acupuncture stimulation was applied to Baihui (GV 20), Zhongwan (CV 12), and bilateral Zusanli (ST 36), Sanyinjiao (SP 6), Yin-lingquan (SP 9) and Fenglong (ST 40) for 40 min, twice daily for 6 weeks except the weekends. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) were detected by using a full-automatic biochemistry analyzer before and after the treatment. The therapeutic effect was assessed according to the standards described in "Guide Principles for Clinical Researches of New Chinese Herbal Drugs".After the treatment, the levels of serum TC, TG of the two groups were significantly decreased in comparison with pre-treatment in the same one group (P<0.05), and the therapeutic effect of the acupuncture+medication group was significantly superior to that of simple medication group in lowering serum TC, TG and LDL-C levels and heightening HDL-C levels (P<0.05). Of the two 30 cases in the medication and acupuncture+medication groups, 2 (6.7%) and 7 (23.3%) were basically controlled in their blood-lipid levels, 10 (33.3%) and 15 (50.0%) had a marked improvement, 10 (33.3%) and 6 (20.0%) were improved, and 8 (26.7%) and 2 (6.7%) were invalid, with the effective rates being 73.3% and 93.3%, respectively.Acupuncture combined with administration of Lipitor is effective in improving primary hyperlipidemia in patients, which is superior to administration of simple Lipitor.
Preparation of cross-linked, multilayer-coated fluorescent microspheres with functional groups on the surface for bioconjugation. - ACS applied materials & interfaces
This study is to develop a method for preparing fluorescent microspheres with steady and strong fluorescence as well as the surface functionality for bioconjugation. Layer-by-layer technique was employed to introduce poly(phenylenevinylene) (PPV) precursor, diazoresin (DAR), and polyanion, including poly(acrylic acid) (PAA) and poly(sodium-p-styrenesulfonate) (PSS), onto the substrate polystyrene-divinylbenzene microspheres with sulfonic groups on the surface (SPSDVB). The conversion of PPV precursor into fluorescent PPV as well as the cross-linking reaction between DAR and polyanion, were accomplished simultaneously in the following thermal treatment. After optimizing the DAR concentration, the selection of polyelectrolytes and the coating sequence, the cross-linked multilayer coated PPV microspheres, SPSDVB-(PPV/PSS/DAR/PAA) spheres, were prepared. These spheres were found to have uniform size with a clear core-shell structure and display even and strong fluorescence, based on the characterization by flow cytometry, microscopy, and photophysics. They were found to be stable and highly resistant to common solvents and even "dissociation agent", as well as possess good thermal stability and photostability. The feasibility of conjugating biomolecules on the surface of spheres was also demonstrated.
Virtual medical plant modeling based on L-system. - African health sciences
Searching the drug molecules from the medicinal plants become more and more popular given that herbal components have been widely considered to be safe. In medical virtual plant studies, development rules are difficult to be extracted, the construction of plant organs is highly dependent on equipment and the process is complicated.To establish three-dimensional structural virtual plant growth model.The quasi-binary tree structure and its properties were obtained through the research of theory on binary tree, then the relationship between quasi-binary tree structure and plant three-dimensional branching structure model was analyzed, and the three-dimensional morphology of plants was described.A three-dimensional plant branch structure pattern extracting algorithm based on quasi-binary tree structure. By using 3-D L-system method, the extracted rules were systematized, and standardized. Further more, we built a comprehensive L-model system. With the aid of graphics and PlantVR, we implemented the plant shape and 3-D structure's reconstruction.Three-dimensional structure virtual plant growth model based on time-controlled L-system has been successfully established.
Exploring the chemical bonding, infrared and UV-vis absorption spectra of OH radicals adsorption on the smallest fullerene. - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
In the present work, the density-functional theory calculations were performed on C20 hydroxylated fullerene. B3LYP functionals with 6-31G(d,p) basis set were utilized to gain insight into the bonding characters and intramolecular interactions of hydroxyl groups adsorbed on the cage. Interestingly, we observed that the C20 cage has the bonding patterns with spherical orbitals configuration [1S(2)1P(6)1D(10)1F(2)], and the adsorbed hydroxyl groups significantly affect the chemical bonding of the cage surface. Analysis of vertical electron affinities and vertical ionization potentials indicates that the polyhydroxylated derivative with eight hydroxyl groups is more stable than others. The intramolecular interaction of these derivatives considered here reveals that the more the hydroxyl groups in derivatives, the stronger the interaction in stabilizing structures. On the basis of theoretical studies, the hydroxyl groups largely enhance the infrared intensities, especially for the polyhydroxylated derivatives.Copyright Â© 2015 Elsevier B.V. All rights reserved.
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Mmc - Dept. Of Anesthesiology 111 East 210Th Street Bronx, NY 10467
111 E 210Th St Montefiore Medical Center
3444 Kossuth Ave Family Care Center, Pediatric Practice C
111 E 210Th St
111 E 210Th St Montefiore Medical Ctr Klau 2 Psychiatry
111 E 210Th St Department Of Pediatrics
Mmc - Dept. Of Anesthesiology 111 East 210Th Street
Mmc - Stern Stroke Ctr 111 East. 210Th St, Nw8 Blue Z