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Dr. Burnett  Rucker  Md image

Dr. Burnett Rucker Md

2615 Eye St
Bakersfield CA 93301
661 953-3000
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: A34349
NPI: 1376553008
Taxonomy Codes:
207Q00000X

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Publications

Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions. - Dermatology (Basel, Switzerland)
The heat shock protein H11 is silenced in melanoma cell lines, where its forced expression by demethylation with Aza-C triggers apoptosis.To examine whether H11 is silenced by aberrant DNA methylation in melanoma as compared to nevi and normal skin tissues.Cell suspensions from benign intradermal nevi, atypical nevi and malignant melanoma tissues were used in reverse-transcriptase PCR and methylation-specific PCR. Paraffin-embedded tissues were stained with H11 antibody.H11 is methylated in 60-75% of melanoma and atypical nevi, but not in normal skin or most benign nevi. Methylation is inversely correlated with H11 expression.The heat shock protein H11 is silenced by aberrant DNA methylation in melanoma, but not benign melanocytic lesions or normal skin melanocytes. The data suggest that H11 is a promising target for the molecular therapy of melanoma.

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2615 Eye St Bakersfield, CA 93301
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