300 W Huntington Dr
Arcadia CA 91007
Medical School: Other - 1987
Accepts Medicare: Yes
Participates In eRX: No
Participates In PQRS: Yes
Participates In EHR: Yes
License #: A53823
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Dr. Zheng Wang is associated with these group practices
|HCPCS Code||Description||Average Price||Average Price
Allowed By Medicare
|HCPCS Code:01402||Description:Anesth knee arthroplasty||Average Price:$2,035.79||Average Price Allowed
|HCPCS Code:00790||Description:Anesth surg upper abdomen||Average Price:$1,504.76||Average Price Allowed
|HCPCS Code:64448||Description:N block inj fem cont inf||Average Price:$1,200.00||Average Price Allowed
|HCPCS Code:00740||Description:Anesth upper gi visualize||Average Price:$918.75||Average Price Allowed
|HCPCS Code:76942||Description:Echo guide for biopsy||Average Price:$200.00||Average Price Allowed
HCPCS Code Definitions
- Ultrasonic guidance for needle placement (eg, biopsy, aspiration, injection, localization device), imaging supervision and interpretation
- Injection, anesthetic agent; femoral nerve, continuous infusion by catheter (including catheter placement)
Medical Malpractice Cases
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Cardiovascular Disease (Cardiology)
*These referrals represent the top 10 that Dr. Wang has made to other doctors
Nomograms for survival prediction in patients undergoing liver resection for hepatitis B virus related early stage hepatocellular carcinoma. - European journal of cancer (Oxford, England : 1990)
The long-term outcomes of patients who underwent liver resection (LR) for early-stage hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) are difficult to predict. This study aimed to develop two nomograms to predict postoperative disease-free survival (DFS) and overall survival (OS), respectively.Data on a primary cohort of 1328 patients who underwent LR for HBV-related HCCs within Milan criteria at the Eastern Hepatobiliary Surgery Hospital (EHBH) from 2000 to 2006 were used to develop the nomograms by the Cox regression analyses. An internal validation cohort of 442 patients operated from 2006 to 2011 at the EHBHÂ and an external validation cohort of 474 patients operated from 2007 to 2009 at the Zhongshan Hospital were used for validation studies. Discrimination and calibration were measured using concordance index (C-index), calibration plots and Kaplan-Meier curves.The independent predictors of DFS or OS which included tumour stage factors, biomarker and HBV-DNA level were respectively incorporated into the two nomograms. In the primary cohort, the C-indexes of the models in predicting DFS and OS were 0.76 (95% confidence interval: 0.75-0.78) and 0.79 (0.77-0.81), respectively. The calibration curves fitted well. Both nomograms accurately stratify patients into four distinct incremental prognostic subgroups. The C-indexes of the nomogram for OS prediction was significantly higher than those of the six conventional staging systems (0.65-0.71, all P<0.001). These results were verified by the internal and external validations.The proposed nomograms showed good prognostication for patients with early HBV-related HCCs after hepatectomy.Copyright Â© 2016 Elsevier Ltd. All rights reserved.
Cell-Targeting Cationic Gene Delivery System Based on a Modular Design Rationale. - ACS applied materials & interfaces
En route to target cells, a gene carrier faces multiple extra- and intracellular hurdles that would affect delivery efficacy. Although diverse strategies have been proposed to functionalize gene carriers for individually overcoming these barriers, it is challenging to generate a single multifunctional gene carrier capable of surmounting all these barriers. Aiming at this challenge, we have developed a supramolecular modular approach to fabricate a multifunctional cationic gene delivery system. It consists of two prefunctionalized modules: (1) a host module: a polymer (PCD-SS-PDMAEMA) composed of poly(Î²-cyclodextrin) backbone and disulfide-linked PDMAEMA arms, expectedly acting to compact DNA and release DNA upon cleavage of disulfide linkers in reductive microenvironment; and (2) a guest module: adamantyl and folate terminated PEG (Ad-PEG-FA), expectedly functioning to reduce nonspecific interactions, improve biocompatibility, and provide folate-mediated cellular targeting specificity. Through the host-guest interaction between Î²-cyclodextrin units of the "host" module and adamantyl groups of the "guest" module, the PCD-SS-PDMAEMA-1 (host) and Ad-PEG-FA (guest) self-assemble forming a supramolecular pseudocopolymer (PCD-SS-PDMAEMA-1/PEG-FA). Our comprehensive analyses demonstrate that the functions preassigned to the two building modules are well realized. The gene carrier effectively compacts DNA into stable nanosized polyplexes resistant to enzymatic digestion, triggers DNA release in reducing environment, possesses significantly improved hemocompatibility, and specifically targets folate-receptor positive cells. Most importantly, endowed with these predesigned functions, the PCD-SS-PDMAEMA-1/PEG-FA supramolecular gene carrier exhibits excellent transfection efficacy for both pDNA and siRNA. Thus, this work represents a proof-of-concept example showing the efficiency and convenience of an adaptable, modular approach for conferring multiple functions to a single supramolecular gene carrier toward effective in vivo delivery of therapeutic nucleic acids.
The Effects of Xiangqing Anodyne Spray on Treating Acute Soft-Tissue Injury Mainly Depend on Suppressing Activations of AKT and p38 Pathways. - Evidence-based complementary and alternative medicine : eCAM
Objectives. In the present study we try to elucidate the mechanism of Xiangqing anodyne spray (XQAS) effects on acute soft-tissue injury (STI). Methods. Acute STI model was established by hammer blow in the rat hind leg muscle. Within 8 hours, instantly after modeling and per 2-hour interval repeated topical applications with or without XQAS, CP or IH ethanol extracts spray (CPS and IHS) were performed, respectively; muscle swelling rate and inflammation-related biochemical parameters, muscle histological observation, and mRNA and protein expression were then examined. Results. XQAS dose-dependently suppressed STI-caused muscle swelling, proinflammatory mediator productions, and oxidative stress as well as severe pathological changes in the injured muscle tissue. Moreover, CPS mainly by blocking p38 activation while IHS majorly by blocking AKT activation led to cytoplastic IÎºBÎ± degradation with NF-ÎºB p65 translocated into the nucleus. There are synergistic effects between CP and IH components in the XQAS on preventing from acute STI with suppressing IÎºBÎ± degradation, NF-ÎºB p65 translocation, and subsequent inflammation and oxidative stress-related abnormality. Conclusion. Marked effects of XQAS on treating acute STI are ascribed to strong anti-inflammatory and antioxidative actions with a reasonable combination of CP active components, blocking p38-NF-ÎºB pathway activated, and IH active components, blocking AKT-NF-ÎºB pathway activated.
Complete Genome Sequence of Labrenzia sp. Strain CP4, Isolated from a Self-Regenerating Biocathode Biofilm. - Genome announcements
Here, we present the complete genome sequence of Labrenzia sp. strain CP4, isolated from an electricity-consuming marine biocathode biofilm. Labrenzia sp. strain CP4 consists of a circular 5.2 Mbp chromosome and an 88 Kbp plasmid.Copyright Â© 2016 Wang et al.
Synthesis of new 4-anilinoquinazoline analogues and evaluation of their EGFR inhibitor activity. - Yao xue xue bao = Acta pharmaceutica Sinica
Thirteen of 4-anilinoquinazoline derivatives with imine groups at position 6 of quinazoline ring were synthesized and their antitumor activities were evaluated by MTT assay and Western blotting analysis. Among these compounds, 13a-131 were reported first time. The MTT assay was carried out on three human cancer cell lines (A549, HepG2 and SMMC7721) with EGFR highly expressed. Among the tested compounds, 13i and 13j exhibited notable inhibition potency and their IC50 values on three cell lines were equivalent to or less than those of gefitinib. Compound 14, without imine group substituted, displayed excellent inhibitor potency only on A549 cell line. Compounds 14 and 13j were chosen to perform Western blotting analysis on A549. The results showed that both of the compounds could inhibit the expression level of phosphorylated EGFR remarkably. It was concluded that the inhibitor potency of compound 14 was almost equivalent to that of gefitinib and the inhibitor potency of 13j was better than that of gefitinib.
Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder. - Journal of autism and developmental disorders
Sensorimotor abnormalities are common in individuals with autism spectrum disorder (ASD); however, the processes underlying these deficits remain unclear. This study examined force production with and without visual feedback to determine if individuals with ASD can utilize internal representations to guide sustained force. Individuals with ASD showed a faster rate of force decay in the absence of visual feedback. Comparison of force output and tests of social and verbal abilities demonstrated a link between motor memory impairment and social and verbal deficits in individuals with ASD. This finding suggests that deficits in storage or retrieval of motor memories contribute to sensorimotor deficits and implicates frontoparietal networks involved in short-term consolidation of action dynamics used to optimize ongoing motor output.
Quantitative imaging analysis and investigation of transmission loss in PbF2 crystals by laser ablation-inductively coupled plasma-mass spectrometry method. - Talanta
We developed a procedure for preparing matrix-matched calibration standards for the quantitative imaging of multiple trace elements in PbF2 crystals by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). In this facile approach, PbO powder was employed as the matrix with the addition of a series of standard solutions, followed by drying and tableting, for determining the concentrations of (24)Mg, (27)Al, (89)Y, (103)Rh, (133)Cs, (175)Lu and (209)Bi in transparent samples (with homogeneous element distribution). (206)Pb was chosen as the internal standard and the correlation coefficients of the calibration curves for all elements ranged from 0.9987 to 0.9999 after internal standard correction. The analysis showed good agreement with the results observed by established ICP-MS methods, following acid dissolution of the samples. Finally, the element distributions and transmission curves of a PbF2 sample with non-transparent and transparent sections were visualized. The distribution images, in conjunction with the transmission curves, suggested that the enrichment of Mg, Al, Rh, Cs, and Bi atoms in the non-transparent section of the sample could explain the loss in transmission observed for that section.Copyright Â© 2016 Elsevier B.V. All rights reserved.
Continuing Reassortant of H5N6 Subtype Highly Pathogenic Avian Influenza Virus in Guangdong. - Frontiers in microbiology
First identified in May 2014 in China's Sichuan Province, initial cases of H5N6 avian influenza virus (AIV) infection in humans raised great concerns about the virus's prevalence, origin, and development. To evaluate both AIV contamination in live poultry markets (LPMs) and the risk of AIV infection in humans, we have conducted surveillance of LPMs in Guangdong Province since 2013 as part of environmental sampling programs. With environmental samples associated with these LPMs, we performed genetic and phylogenetic analyses of 10 H5N6 AIVs isolated from different cities of Guangdong Province from different years. Results revealed that the H5N6 viruses were reassortants with hemagglutinin (HA) genes derived from clade 188.8.131.52 of H5-subtype AIV, yet neuraminidase (NA) genes derived from H6N6 AIV. Unlike the other seven H5N6 viruses isolated in first 7 months of 2014, all of which shared remarkable sequence similarity with the H5N1 AIV in all internal genes, the PB2 genes of GZ693, GZ670, and ZS558 more closely related to H6N6 AIV and the PB1 gene of GZ693 to the H3-subtype AIV. Phylogenetic analyses revealed that the environmental H5N6 AIV related closely to human H5N6 AIVs isolated in Guangdong. These results thus suggest that continued reassortment has enabled the emergence of a novel H5N6 virus in Guangdong, as well as highlight the potential risk of highly pathogenic H5N6 AIVs in the province.
Optimal chin-brow vertical angle for sagittal visual fields in ankylosing spondylitis kyphosis. - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Chin-brow vertical angle (CBVA) is very important in correction of thoracolumbar kyphotic deformity in ankylosing spondylitis (AS), especially for the patients with cervical ankylosis. In previous study, Suk et al. stated that the patients with CBVA between -10Â° and 10Â° had better horizontal gaze. Unfortunately, in our clinical practice, we found the patients with CBVA between -10Â° and 10Â° after surgery usually complained of difficulty in cooking, cleaning, desk working and the like, although they had excellent horizontal gaze. In other words, for the patients with cervical ankylosis, good horizontal gaze existed together with poor downward gaze. Then, which condition do the patients prefer? Is there a compromise solution that makes a better quality life possible for the patients? In this research, we studied AS patients with cervical ankylosis, aiming to investigate the optimal CBVA for deformity correction.25 AS thoracolumbar kyphotic patients with cervical ankylosis were studied, whose function and expectation of visual field related to life quality were assessed by questionnaire before and after surgery. Pre- and post-operative CBVA were obtained on lateral photos of the patients with free-standing posture, and 50 cases of CBVA were included, which were divided into six groups according to the angle irrespective of surgery (Group A, CBVAÂ <0Â°; Group B, 0Â°Â â‰¤Â CBVAÂ <Â 10Â°; Group C, 10Â°Â â‰¤Â CBVAÂ <Â 20Â°; Group D, 20Â°Â â‰¤Â CBVAÂ <Â 30Â°; Group E, 30Â°Â â‰¤Â CBVAÂ <Â 40Â°; Group F, CBVAÂ â‰¥Â 40Â°). Kruskal-Wallis test was used to assess all the groups in terms of various items in the questionnaire, while Mann-Whitney test was used to assess every two groups.In overall evaluation, Group C (10Â°-20Â°) obtained the optimal expectation (pÂ <Â 0.05); Group B, C and D (0Â°-30Â°) obtained better function (pÂ <Â 0.05), and there was no significant difference between the 3 groups. In appearance, Group A, B and C (<20Â°) were better than the other groups both in function and expectation (pÂ <Â 0.05), without dramatic difference among the three groups. In outdoor activities, Group A, B, C and D (<30Â°) were better in most of the items (pÂ <Â 0.05). In indoor activities, Group C and D (10-30Â°) were much better (pÂ <Â 0.05).AS thoracolumbar kyphotic patients with cervical ankylosis had the best satisfaction when 10Â°Â â‰¤Â CBVAÂ <Â 20Â°.
Geometrical tuning art for entirely subwavelength grating waveguide based integrated photonics circuits. - Scientific reports
Subwavelength grating (SWG) waveguide is an intriguing alternative to conventional optical waveguides due to the extra degree of freedom it offers in tuning a few important waveguide properties, such as dispersion and refractive index. Devices based on SWG waveguides have demonstrated impressive performances compared to conventional waveguides. However, the high loss of SWG waveguide bends jeopardizes their applications in integrated photonic circuits. In this work, we propose a geometrical tuning art, which realizes a pre-distorted refractive index profile in SWG waveguide bends. The pre-distorted refractive index profile can effectively reduce the mode mismatch and radiation loss simultaneously, thus significantly reduce the bend loss. This geometry tuning art has been numerically optimized and experimentally demonstrated in present study. Through such tuning, the average insertion loss of a 5â€‰Î¼m SWG waveguide bend is reduced drastically from 5.43â€‰dB to 1.10â€‰dB per 90Â° bend for quasi-TE polarization. In the future, the proposed scheme will be utilized to enhance performance of a wide range of SWG waveguide based photonics devices.
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