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Dr. Lauren  Murrill  Md image

Dr. Lauren Murrill Md

2160 S 1St Ave Building 105, Room 1870
Maywood IL 60153
708 161-1676
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 125061537
NPI: 1366708554
Taxonomy Codes:
207Y00000X

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Publications

Robust Differences in p16-Dependent Oropharyngeal Squamous Cell Carcinoma Distant Metastasis: Implications for Targeted Therapy. - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Historically, head and neck squamous cell carcinoma (HNSCC) has been earmarked a lymphatic malignancy. Recently, this has been called into question. Our study aims to (1) illustrate the robust differences in distant metastases between p16+ and p16- oropharyngeal squamous cell carcinoma (OPSCC) and (2) provide support that p16+ OPSCC has a predilection toward vasculature invasion and hematogenous spread.Multi-institutional, case series with chart review.Four academic institutions.Within a group of 1113 patients with primary OPSCC who received treatment between 1979 and 2013, those who developed distant metastasis (DM) were divided into 2 cohorts based on p16 status. Intergroup and intragroup univariate analysis was performed as well as descriptive analysis of end-organ sites.Of the 1058 patients included, 89 developed DM. Thirty were p16- and 59 were p16+. Of the p16- patients with DM, only 10% had disseminated disease (distant metastases at ≥2 sites) compared with 74% of p16+ patients. Distant disease in p16+ patients included brain, abdomen, and a distinct pattern of pulmonary metastases.Our large, multi-institutional study supports published reports that p16+ OPSCC metastasizes with a unique phenotype that is hematogenous and widely disseminated with atypical end-organ sites. Our data suggest that p16+ OPSCC has a predilection toward active vasculature invasion as evidenced by the results and illustrative radiologic and pathohistologic examples. These findings may have implications for future targeted therapy when treating p16+ OPSCC.© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.
Asthma: symptoms and presentation. - Otolaryngologic clinics of North America
The goal of this article is to inform readers of the common and uncommon signs and symptoms of asthma. After completion of this article, readers should have a firm understanding of the symptoms and presentation leading to a diagnosis of asthma.Copyright © 2014 Elsevier Inc. All rights reserved.

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2160 S 1St Ave Building 105, Room 1870 Maywood, IL 60153
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