42 Orange Ave
Larkspur CA 94939
Medical School: Other - Unknown
Accepts Medicare: No
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Participates In PQRS: No
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License #: G20141
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Topical application of activity-based probes for visualization of brain tumor tissue. - PloS one
Several investigators have shown the utility of systemically delivered optical imaging probes to image tumors in small animal models of cancer. Here we demonstrate an innovative method for imaging tumors and tumor margins during surgery. Specifically, we show that optical imaging probes topically applied to tumors and surrounding normal tissue rapidly differentiate between tissues. In contrast to systemic delivery of optical imaging probes which label tumors uniformly over time, topical probe application results in rapid and robust probe activation that is detectable as early as 5 minutes following application. Importantly, labeling is primarily associated with peri-tumor spaces. This methodology provides a means for rapid visualization of tumor and potentially infiltrating tumor cells and has potential applications for directed surgical excision of tumor tissues. Furthermore, this technology could find use in surgical resections for any tumors having differential regulation of cysteine cathepsin activity.
Nonparametric identification of the elbow joint stiffness under compliant loads. - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Several nonparametric system identification techniques have been used to estimate the dynamic joint stiffness of the human elbow. Most studies involved a very stiff environment, but some studies have also shown that stiffness is modified in response to environmental compliance. However, using the same identification technique used under very stiff conditions to do identification under compliant conditions leads to a biased estimate. This is due to the presence of feedback in the latter. In this paper, we use a nonparametric identification algorithm to demonstrate this problem. We then show how instrumental variables can be employed to obtain an unbiased estimate of the same. Both simulations as well as experimental data are used to this effect.
Cell-associated magnesium and QT dispersion in hemodialysis patients. - American journal of kidney diseases : the official journal of the National Kidney Foundation
Impaired magnesium (Mg) homeostasis has been implicated in a variety of cardiovascular disturbances, including ventricular arrhythmias and changes in the interval between the onset of wave Q to the end of wave T (QT interval) on electrocardiogram. Cardiac arrhythmias are common in patients on hemodialysis therapy.We investigated the relationship between QT interval corrected for heart rate (QTc) dispersion and Mg content in peripheral blood mononuclear cells (PBMC) of chronic hemodialysis patients treated with high-dose calcium carbonate providing Mg in excess (group I; n = 18) or low-dose calcium carbonate and smaller Mg load (group II; n = 13).Mean Mg content in PBMC of group I patients (27.9 +/- 4.2 [SD] micromol/L/mg protein) was significantly greater than in group II patients (10.4 +/- 4.1 micromol/L/mg protein; P < 0.05) and greater in both groups than in healthy control subjects (2.75 +/- 0.6 micromol/L/mg protein; P < 0.05). Mean QTc dispersion was significantly longer (74.6 +/- 21.4 milliseconds) in group I than group II (37.8 +/- 13.1 milliseconds; P < 0.02) and longer in both groups than in controls (27.3 +/- 9.6 milliseconds; P < 0.05). After dialysis, in both groups of patients, cell-associated Mg (c-a Mg) levels and QTc dispersion were significantly greater (P < 0.05) than before dialysis started. One week after stopping calcium carbonate treatment, group 1 patients showed significant reductions in predialytic c-a Mg levels (to 19.5 +/- 9.8 micromol/L/mg protein; P < 0.05) and QTc dispersions (to 48.9 +/- 23.7 milliseconds; P < 0.05). Plasma Mg and other electrolyte concentrations prior to and during hemodialysis did not correlate with QTc dispersion.Prolongation of QTc dispersion in patients on chronic hemodialysis therapy could be, at least in part, a consequence of increased concentrations of c-a Mg resulting from excess daily Mg intake.Copyright 2003 by the National Kidney Foundation, Inc.
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42 Orange Ave Larkspur, CA 94939
18 Bon Air Rd
2 Bon Air Rd Suite 120
2 Bon Air Rd Suite 100
2 Bon Air Rd #100