Dr. Sandeep  Sandhu  Md image

Dr. Sandeep Sandhu Md

14139 Potomac Mills Rd
Woodbridge VA 22192
703 907-7672
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: MT187339
NPI: 1295956563
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Polymerase Chain Reaction on a Viral Nanoparticle. - ACS synthetic biology
The field of synthetic biology includes studies that aim to develop new materials and devices from biomolecules. In recent years, much work has been carried out using a range of biomolecular chassis including α-helical coiled coils, β-sheet amyloids and even viral particles. In this work, we show how hybrid bionanoparticles can be produced from a viral M13 bacteriophage scaffold through conjugation with DNA primers that can template a polymerase chain reaction (PCR). This unprecedented example of a PCR on a virus particle has been studied by flow aligned linear dichroism spectroscopy, which gives information on the structure of the product as well as a new protototype methodology for DNA detection. We propose that this demonstration of PCR on the surface of a bionanoparticle is a useful addition to ways in which hybrid assemblies may be constructed using synthetic biology.

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14139 Potomac Mills Rd Woodbridge, VA 22192
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