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Dr. Nicole  Boutaugh  Do image

Dr. Nicole Boutaugh Do

76 High St
Lewiston ME 04240
207 955-5800
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: TP13108
NPI: 1144668914
Taxonomy Codes:
207Q00000X

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Publications

B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection. - Interdisciplinary perspectives on infectious diseases
Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB/cJ mice and IgD deficient BALB/c-Igh-5(-/-J) mice to oral infection with Porphyromonas gingivalis, a gram-negative periodontopathic bacterium from humans. P. gingivalis-infected normal mice lost bone. Specific antibody to P. gingivalis was lower and oral colonization was higher in IgD deficient mice; yet bone loss was completely absent. Infection increased the proportion of CD69(+) activated B cells and CD4(+) T cells in immune normal mice compared to IgD deficient mice. These data suggest that IgD is an important mediator of alveolar bone resorption, possibly through antigen-specific coactivation of B cells and CD4(+) T cells.

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76 High St Lewiston, ME 04240
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