Docality.com Logo
 
Dr. Michael  Thylin  Dds image

Dr. Michael Thylin Dds

3144 El Camino Real Suite 203
Carlsbad CA 92008
760 309-9700
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 51143
NPI: 1134139819
Taxonomy Codes:
1223G0001X

Request Appointment Information

Awards & Recognitions

About Us

Practice Philosophy

Conditions

Medical Malpractice Cases

None Found

Medical Board Sanctions

None Found

Referrals

None Found

Publications

Effects of simvastatin gels on murine calvarial bone. - Journal of periodontology
The cholesterol-lowering drug simvastatin has been shown to stimulate murine calvarial bone growth after multiple injections. The purpose of this study was to test if similar bone stimulation could be induced by 2 single-dose drug delivery systems appropriate to periodontal therapy.ICR Swiss mice were treated with the following protocols: 1) injection of methylcellulose gel alone, subcutaneously over the calvarium (INJ-GEL; n = 8); 2) injection of gel with simvastatin (INJ-SIM; 2.2 mg, n = 16); 3) polylactide membrane (PLA) containing gel alone implanted over calvarium (MEM-GEL; n = 10); 4) implanted PLA membrane containing gel and simvastatin (MEM-SIM; n = 10); and 5) untreated mice (n = 12). Animals were sacrificed after 22 or 44 days, calvaria decalcified and stained with hematoxylin and eosin, and images digitized and measured for bone thickness and area. Data were compared using analysis of variance.INJ-SIM stimulated a 53% (P = 0.02) increase at the thickest point of calvarial bone, while MEM-SIM caused a highly significant (P < or = 0.0005) increase in bone thickness (159% to 172%) and bone area (144% to 180%) compared to gel controls. Simvastatin gels caused soft tissue inflammation, which appeared to be related to bone increases. If INJ-SIM animals showing leakage of gel and/or no inflammation were excluded from analysis, INJ-SIM resulted in more bone (58% to 83%) than gel controls. An insignificant amount of SIM-stimulated bone was lost over the long term (44 days).A single, high dose of simvastatin gel can stimulate murine cranial bone apposition, particularly when delivered under an occlusive membrane. Both approaches should be investigated further for possible development for periodontal therapy.

Map & Directions

3144 El Camino Real Suite 203 Carlsbad, CA 92008
View Directions In Google Maps

Nearby Doctors

2630 El Camino Real
Carlsbad, CA 92008
760 341-1761
2562 State St Ste D
Carlsbad, CA 92008
760 297-7186
2725 Jefferson St Ste 6-103
Carlsbad, CA 92008
760 889-9364
590 Laguna Dr
Carlsbad, CA 92008
760 346-6141
725 Grand Ave
Carlsbad, CA 92008
760 294-4904
740 Oak Ave #B
Carlsbad, CA 92008
760 296-6455
2725 Jefferson St Suite 10
Carlsbad, CA 92008
760 345-5900
3144 El Camino Real Suite 100
Carlsbad, CA 92008
760 303-3536
590 Laguna Dr
Carlsbad, CA 92008
760 346-6141
570 Laguna Dr Suite A
Carlsbad, CA 92008
760 347-7374