Dr. Kornelia  Mikhats   image

Dr. Kornelia Mikhats

19 Elm St
Greenvale NY 11548
516 608-8688
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 611669427
NPI: 1093128555
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Oxime-type acetylcholinesterase reactivators in pregnancy: an overview. - Archives of toxicology
Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs irreversibly inhibit acetylcholinesterase (AChE) at nerve synapses. Furthermore, the role of AChE other than neurotransmission termination has been defined in the literature. The growing evidences show that cholinergic mechanisms are involved during growth and development of other organ systems. In contrary to the fact, the data on the use of oxime-AChER in OPC poisoning in pregnancy are scanty. The present review aimed to comprehend the status of oximes in pregnancy in lieu of the published literature. A thorough literature search was performed in January 2013, using ten popular search engines including Medline/PubMed, Google scholar, etc., using nine standard keywords. The search period was set from 1966 to present. The search did not reveal substantial data. No considerable studies were retrieved which could really demonstrate either the beneficial, harmful or even null effect of oxime-AChER usage in pregnancy. Only eighteen relevant articles were obtained for a period of about 47 years. In the literature, there is no report available to demonstrate the risk of using oxime-AChER in pregnancy for the treatment of OPC poisoning. The study reveals that the use of oxime-AChER in pregnancy is largely un-addressed, inconclusive and based on speculation albeit the incidences of OPC poisoning are quite prevalent. Well-designed studies are warranted for a tangible conclusion.
High resolution computed tomography in 2-year follow-up of Stage I sarcoidosis. - Advances in experimental medicine and biology
There are as yet no markers known to predict the course of sarcoidosis. High resolution computed tomography (HRCT) is a tool that enables to visualize subtle parenchymal opacities in the lungs. Therefore, the aim of this study was to assess the prognostic role of HRCT at Stage I sarcoidosis. Fifty one patients (28 males and 23 females, aged 23-58) were studied. Based on HRCT examinations, two groups were distinguished: HRCT-positive (28 patients with pathologic changes in pulmonary parenchyma - mainly nodular opacities) and HRCT-negative (23 patients without parenchymal opacities). We found no significant differences between HRCT-negative and HRCT-positive groups in the mean values of pulmonary function tests (FEV1, FVC, FEV1/FVC, DLCO, and d(A-a)O2) between the starting and ending measurements of a 2-year long observation (check-up every 3 months). Likewise, there were no differences in the X-ray follow-up between the HRCT-positive and HRCT-negative groups. Nor were there significant differences in the percentage of patients showing stabilization, progression, or improvement between both groups (18 vs. 39 %, 21 vs. 4 %, and 61 vs. 57 %, respectively). We conclude that HRCT examination in stage I sarcoidosis has no significant prognostic role during a 2-year follow-up.

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