Docality.com Logo
 
Dr. Judith Kathleen Kremposky  Phd image

Dr. Judith Kathleen Kremposky Phd

1809 Sidney St
Pittsburgh PA 15203
412 819-9141
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: PS003308L
NPI: 1053332502
Taxonomy Codes:
103TC0700X

Request Appointment Information

Awards & Recognitions

About Us

Practice Philosophy

Conditions

Medical Malpractice Cases

None Found

Medical Board Sanctions

None Found

Referrals

None Found

Publications

Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. - Critical care (London, England)
Preoperative hemodilution is an established practice that is applied to reduce surgical blood loss. It has been proposed that polyethylene glycol (PEG) surface decorated proteins such as PEG-conjugated human serum albumin may be used as non-oxygen-carrying plasma expanders. The purpose of this study was to determine whether there is any difference in survival time after severe hemorrhagic shock following extreme hemodilution using a conventional hydroxyethyl starch (HES)-based plasma expander or PEG-albumin.Experiments were performed using the hamster skinfold window preparation. Human serum albumin that was surface decorated with PEG was compared with Voluven 6% (Fresenius Kabi, Austria; a starch solution that is of low molecular weight and has a low degree of substitution; HES). These plasma expanders were used for a 50% (blood volume) exchange transfusion to simulate preoperative hemodilution. Exchange transfusion was followed by a 60% (blood volume) hemorrhage to reproduce a severe surgical bleed over a 1 hour period. Observation of the animal was continued for another hour during the shock phase.The PEG-albumin group exhibited significantly greater survival rate than did the HES group, in which none of the animals survived the hemorrhage phase of the experiment. Among the treatment groups there were no changes in mean arterial pressure and heart rate from baseline after hemodilution. Both groups experienced gradual increases in arterial oxygen tension and disturbance in acid-base balance, but this response was more pronounced in the HES group during the shock period. Mean arterial pressure remained elevated after the initial hemorrhage period in the PEG-albumin group but not in the HES group. Maintenance of a greater mean arterial pressure during the initial stages of hemorrhage is proposed to be in part due to the improved volume expansion with PEG-albumin, as indicated by the significant decrease in systemic hematocrit compared with the HES group. PEG-albumin treatment yielded higher functional capillary density during the initial stages of hemorrhage as compared with HES treatment.The ability of PEG-albumin to prolong maintenance of microvascular function better than HES is a finding that would be significant in a clinical setting involving preoperative blood management and extreme blood loss.

Map & Directions

1809 Sidney St Pittsburgh, PA 15203
View Directions In Google Maps

Nearby Doctors

46 Windom Hill Pl
Pittsburgh, PA 15203
308 209-9826
2000 Mary St
Pittsburgh, PA 15203
412 327-7400
2 Hot Metal St Ermi Quantum One
Pittsburgh, PA 15203
412 327-7424
2 Hot Metal St Ermi Quantum One
Pittsburgh, PA 15203
412 327-7424
1809 Sidney St
Pittsburgh, PA 15203
412 819-9141
3200 S Water St Center For Sports Medicine
Pittsburgh, PA 15203
412 323-3600
1927 E Carson St
Pittsburgh, PA 15203
412 814-4422
2 Hot Metal St Ermi Quantum One
Pittsburgh, PA 15203
412 327-7424
1900 E Carson St
Pittsburgh, PA 15203
412 315-5300
2 Hot Metal St Ermi Quantum One
Pittsburgh, PA 15203
412 327-7424