2406 N Broad St
Colmar PA 18915
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A Comparative Study of Quality of Life in Persons With Irritable Bowel Syndrome and Inflammatory Bowel Disease. - Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder; however, it remains poorly understood. Inflammatory bowel disease (IBD) is a chronic, organic bowel disease characterized by young age of onset, debilitating symptoms, and invasive and toxic treatment options. This study aimed to determine the impact of IBS and IBD on health-related quality of life (HRQoL) and the ways by which these conditions affect HRQoL, with the purpose of informing nurse specialists in gastroenterology who are best placed to support HRQoL improvements. Quality of life, symptom, and demographic data were collected from patients with IBS and IBD and tabulated and examined. Analysis of data demonstrated that HRQoL is significantly lower in IBS than in IBD. However, the ways by which these two conditions affect HRQoL differs, with greater impairments in social and emotional aspects of life in individuals with IBS. Bowel symptoms were the same or worse in IBD.
Experiences of healing therapy in patients with irritable bowel syndrome and inflammatory bowel disease. - BMC complementary and alternative medicine
The use and value of different complementary therapies requires investigation. In particular, qualitative research is required to understand the perceptions and experiences of patients who undergo healing therapy as one type of complementary therapy. The aim of this research is to consider patients perceptions and experiences following a course of healing therapy.Twenty two patients took part in this study. This included 13 patients with irritable bowel disease (3 male, 10 female, 47.6â€‰Â±â€‰15.0Â years), 6 patients with ulcerative colitis (3 male, 3 female, 48.5â€‰Â±â€‰25.6Â years) and 3 female patients with Crohn's Disease (45.0â€‰Â±â€‰5.2Â years). Each patient undertook a single semi-structured interview following a course of healing therapy. The data was analysed using a thematic analysis.Three broad themes were identified from patient interviews (1) The understanding and expectation of healing (2) Experiences and reflection on healing (3) Impact and outcome of healing. The details of each theme are explored within the text, often revealing a unique experience of healing therapy.Patients were open towards the benefits that could be attained by healing, although most patients were not sure what healing would entail. Some patients expected to be relaxed by the sessions. However, the most consistent reports were that patients experienced a relaxing sensation that was generated within the session and lasted for a time period after the sessions. In addition to this the healing appeared to be associated with patients feeling more tolerant of their symptoms. Patients valued the therapist and their input into the healing process. It should be noted however, that this report cannot consider the efficacy of the treatment. Further details and experiences are considered within the article, including one negative experience.
L-methionase: a therapeutic enzyme to treat malignancies. - BioMed research international
Cancer is an increasing cause of mortality and morbidity throughout the world. L-methionase has potential application against many types of cancers. L-Methionase is an intracellular enzyme in bacterial species, an extracellular enzyme in fungi, and absent in mammals. L-Methionase producing bacterial strain(s) can be isolated by 5,5'-dithio-bis-(2-nitrobenzoic acid) as a screening dye. L-Methionine plays an important role in tumour cells. These cells become methionine dependent and eventually follow apoptosis due to methionine limitation in cancer cells. L-Methionine also plays an indispensable role in gene activation and inactivation due to hypermethylation and/or hypomethylation. Membrane transporters such as GLUT1 and ion channels like Na(2+), Ca(2+), K(+), and Cl(-) become overexpressed. Further, the Î±-subunit of ATP synthase plays a role in cancer cells growth and development by providing them enhanced nutritional requirements. Currently, selenomethionine is also used as a prodrug in cancer therapy along with enzyme methionase that converts prodrug into active toxic chemical(s) that causes death of cancerous cells/tissue. More recently, fusion protein (FP) consisting of L-methionase linked to annexin-V has been used in cancer therapy. The fusion proteins have advantage that they have specificity only for cancer cells and do not harm the normal cells.
A fast, stability-indicating, and validated liquid chromatography method for the purity control of lercanidipine hydrochloride in tablet dosage form. - Scientia pharmaceutica
A robust, sensitive, and stability-indicating rapid resolution liquid chromatography method for the simultaneous determination of process impurities and degradation products of lercanidipine hydrochloride in pharmaceutical dosage form was developed and validated. The chromatographic separation was performed on the Zorbax SB C18 [(50 Ã— 4.6) mm] 1.8 Î¼m column, using gradient elution of a potassium dihydrogen phosphate buffer (pH 3.5, 0.01 M) and acetonitrile. The flow rate was 1.0 ml/min and UV detection was performed at 220 nm. The method was further evaluated for its stability-indicating capability by hydrolytic, oxidative, thermal, thermal with moisture, and photolytic degradation studies. All acceptance criteria of the International Conference on Harmonization guidelines for validation were covered in the method validation. This method can be used for purity control during manufacture and real time stability studies. A shorter run time of 10 minutes and good solution stability for at least 48 hours allowed the quantification of more than 50 samples per day with comparatively lower costs than existing methods.
Effect of acyl chain length on selective biocatalytic deacylation on O-aryl glycosides and separation of anomers. - Bioorganic chemistry
It has been demonstrated that LipozymeÂ® TL IM (Thermomyces lanuginosus lipase immobilised on silica) can selectively deacylate the ester function involving the C-5' hydroxyl group of Î±-anomers over the other acyl functions of anomeric mixture of peracylated O-aryl Î±,Î²-D-ribofuranoside. The analysis of results of biocatalytic deacylation reaction revealed that the reaction time decreases with the increase in the acyl chain length from C1 to C4. The unique selectivity of LipozymeÂ® TL IM has been harnessed for the separation of anomeric mixture of peracylated O-aryl Î±,Î²-D-ribofuranosides, The lipase mediated selective deacylation methodology has been used for the synthesis of O-aryl Î±-D-ribofuranosides and O-aryl Î²-D-ribofuranosides in pure forms, which can be used as chromogenic substrate for the detection of pathogenic microbial parasites containing glycosidases.Copyright Â© 2014. Published by Elsevier Inc.
A ferrocene-pyrene based 'turn-on' chemodosimeter for Cr(3+)- application in bioimaging. - Dalton transactions (Cambridge, England : 2003)
Structurally simple, ferrocene-pyrene imine dyad 1 has been developed as a 'turn-on' chemodosimeter for Cr(3+). The sensing event is based upon the hydrolysis of the imine functionality. Further, 1, which is also non-cytotoxic (100% cell viability), detects intracellular Cr(3+) in the human breast cancer (MCF-7) cells.
O-Aryl Î±,Î²-d-ribofuranosides: synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. - Bioorganic & medicinal chemistry
A series of peracetylated O-aryl Î±,Î²-d-ribofuranosides have been synthesized and an efficient biocatalytic methodology has been developed for the separation of their anomers which was otherwise almost impossible by column chromatographic or other techniques. The incubation of 2,3,5-tri-O-acetyl-1-O-aryl-Î±,Î²-d-ribofuranoside with LipozymeÂ® TL IM immobilized on silica led to the selective deacetylation of only one acetoxy group, viz the C-5'-O-acetoxy group of the Î±-anomer over the other acetoxy groups derived from the two secondary hydroxyl groups present in the molecule and also over three acetoxy groups (derived from one primary and two secondary hydroxyls of the Î²-anomer). This methodology led to the easy synthesis of both, Î±- and Î²-anomers of O-aryl d-ribofuranosides. All the arylribofuranosides were screened for inhibition of Src kinase. 1-O-(3-Methoxyphenyl)-Î²-d-ribofuranoside exhibited the highest activity for inhibition of Src kinase (IC(50)=95.0Î¼M).Copyright Â© 2012 Elsevier Ltd. All rights reserved.
Development and validation of a stability-indicating assay method for simultaneous determination of perindopril and indapamide in combined dosage form by reversed-phase high-performance liquid chromatography. - Journal of AOAC International
An approach of forced degradation study was successfully applied for the development of a stability-indicating assay method for simultaneous determination of perindopril and indapamide in a formulation in the presence of its degradation products. The method showed adequate separation of perindopril and indapamide from their associated main impurities and degradation products. Separation was achieved on an XTerra RP18, 5 microm, 150 x 4.6 mm id column at 55 degrees C by using the mobile phase NaH2PO4 buffer (pH 2.0; 0.005 M)-acetonitrile (75 + 25, v/v) at a flow rate of 1 mL/min and UV detection at 215 nm. Comprehensive stress testing of perindopril and indapamide was carried out according to the International Conference on Harmonization (ICH) guideline Q1A (R2). The specificity of the method was determined by assessing interference from the placebo and by stress testing of the drug (forced degradation). The drug was subjected to acid hydrolysis, base hydrolysis, oxidation, dry heat, and photolysis to apply stress conditions. There were no other coeluting, interfering peaks from excipients, impurities, or degradation products due to variable stress conditions, and the method was specific for determination of perindopril and indapamide in the presence of degradation products. The method was validated in terms of linearity, precision, accuracy, specificity, robustness, and solution stability. The linearity of the proposed method was investigated in the range of 24-56 microg/mL (r2 = 0.9993) for perindopril and 7.5-17.5 microg/mL (r2 = 0.9992) for indapamide. Degradation products produced as a result of stress studies did not interfere with the detection of perindopril and indapamide, and the assay can thus be considered stability indicating.
Gut-directed hypnotherapy for irritable bowel syndrome: piloting a primary care-based randomised controlled trial. - The British journal of general practice : the journal of the Royal College of General Practitioners
In western populations irritable bowel syndrome (IBS) affects between 10% and 30% of the population and has a significant effect on quality of life. It generates a substantial workload in both primary and secondary care and has significant cost implications. Gut-directed hypnotherapy has been demonstrated to alleviate symptoms and improve quality of life but has not been assessed outside of secondary and tertiary referral centres.To assess the effectiveness of gut-directed hypnotherapy as a complementary therapy in the management of IBS.Randomised controlled trial.Primary care patients aged 18-65 years inclusive, with a diagnosis of IBS of greater than 6 weeks' duration and having failed conventional management, located in South Staffordshire and North Birmingham, UK.Intervention patients received five sessions of hypnotherapy in addition to their usual management. Control patients received usual management alone. Data regarding symptoms and quality of life were collected at baseline and again 3, 6, and 12 months post-randomisation.Both groups demonstrated a significant improvement in all symptom dimensions and quality of life over 12 months. At 3 months the intervention group had significantly greater improvements in pain, diarrhoea and overall symptom scores (P<0.05). No significant differences between groups in quality of life were identified. No differences were maintained over time. Intervention patients, however, were significantly less likely to require medication, and the majority described an improvement in their condition.Gut-directed hypnotherapy benefits patients via symptom reduction and reduced medication usage, although the lack of significant difference between groups beyond 3 months prohibits its general introduction without additional evidence. A large trial incorporating robust economic analysis is, therefore, urgently recommended.
Using email as a research tool in general practice: starting to implement the National Service Framework for Mental Health. - Informatics in primary care
The first primary care trust milestone for implementation of Standard 2 of the National Service Framework for Mental Health is the use of a formal diagnostic approach to the assessment of the severity of common psychiatric illnesses. Whilst developing a diagnostic tool to assess depressive symptoms, based on the ICD-10 classification of disease, we surveyed the current usage of such diagnostic aids by general practitioners (GPs) in Birmingham. According to the Birmingham Health Authority IT Directorate, 477 GP principals in the city had personal access to email at their practices through the NHSnet.All GPs were sent a short questionnaire by email. They were asked to indicate their responses to four yes/no answers and return the email by pressing the 'Reply' icon. Non-respondents were then sent the questionnaire by post.We had a total response rate of 67%. We received an email response from 105 GPs, or 22%. A further 216 out of a possible 372 GPs (58%) then responded by post. Forty-seven (22%) of the postal respondents had received the email, but 38 of them had problems replying; 150 (69%) said that they had never seen the email.The overall response rate to the questionnaire suggests that the topic was considered sufficiently relevant for GPs to reply and was not the reason for the poor email response. There were no obvious differences in the answers to the questionnaire to suggest that the mental health topic had identified a separate email-using GP population. Although four out of every five Birmingham GPs have access to email, only one in five feels confident or competent to use it as a regular means of professional communication. It is not yet appropriate to use email as the only conduit for obtaining GP opinion.
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