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Dr. Mark Hilton Dds

4585 Washington St C-3
Florissant MO 63033
314 314-4660
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: DE014146
NPI: 1023348489
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Management of Preconditioned Calves and Impacts of Preconditioning. - The Veterinary clinics of North America. Food animal practice
When studying the practice of preconditioning (PC) calves, many factors need to be examined to determine if cow-calf producers should make this investment. Factors such as average daily gain, feed efficiency, available labor, length of the PC period, genetics, and marketing options must be analyzed. The health sales price advantage is an additional benefit in producing and selling PC calves but not the sole determinant of PC's financially feasibility. Studies show that a substantial advantage of PC is the selling of additional pounds at a cost of gain well below the marginal return of producing those additional pounds.Copyright © 2015 Elsevier Inc. All rights reserved.
BRD in 2014: where have we been, where are we now, and where do we want to go? - Animal health research reviews / Conference of Research Workers in Animal Diseases
Bovine respiratory disease (BRD) is a worldwide health concern and is the number one disease of stocker, backgrounder, and feedlot cattle in North America. In feedlots in the USA, BRD accounts for 70-80% of all feedlot morbidity and 40-50% of all mortality. In 2011, the US Department of Agriculture's National Animal Health Monitoring System conducted a feedlot study that showed 16.2% of all feedlot cattle were treated for BRD. It is universally accepted that this number is distressingly high and that our industry has the tools available to reduce the incidence of BRD.
Evaluation of horizontal transmission of bovine viral diarrhea virus type 1a from experimentally infected white-tailed deer fawns (Odocoileus virginianus) to colostrum-deprived calves. - American journal of veterinary research
To assess the transmission of bovine viral diarrhea virus (BVDV) from experimentally infected white-tailed deer fawns to colostrum-deprived calves by use of a BVDV strain isolated from hunter-harvested white-tailed deer.5 white-tailed deer (Odocoileus virginianus) fawns and 6 colostrum-deprived calves.Fawns were inoculated intranasally with a noncytopathic BVDV-1a isolate (2 mL containing 10(6.7) TCID(50)/mL), and 2 days after inoculation, animals were commingled until the end of the study. Blood and serum samples were obtained on days -6, 0, 7, 14, and 21 after inoculation for reverse transcriptase PCR assay, virus neutralization, and BVDV-specific antibody ELISA. Nasal, oral, and rectal swab specimens were collected on days 0, 3, 7, 14, 17, and 21 for reverse transcriptase PCR testing. By 21 days after inoculation, all animals were euthanized and necropsied and tissues were collected for histologic evaluation, immunohistochemical analysis, and virus isolation.All fawns became infected and shed the virus for up to 18 days as determined on the basis of reverse transcriptase PCR testing and virus isolation results. Evidence of BVDV infection as a result of cohabitation with acutely infected fawns was detected in 4 of the 6 calves by means of reverse transcriptase PCR testing and virus isolation.On the basis of these findings, BVDV transmission from acutely infected fawns to colostrum-deprived calves appeared possible.
Survey on management practices related to the prevention and control of bovine viral diarrhea virus on dairy farms in Indiana, United States. - Preventive veterinary medicine
The objective of this cross-sectional study was to describe the application of management practices known to be associated with the prevention of bovine viral diarrhea virus (BVDV) infection on Indiana dairy farms and to determine the extent of BVDV vaccine use within Indiana dairy herds. The population in this study was Indiana dairy producers enrolled under the Indiana Premise ID list by the Indiana State Board of Animal Health (n=1600). During the fall of 2008 a questionnaire was mailed to Indiana dairy producers. Returned questionnaires were entered into a database and descriptive statistics were performed. A total of 208 questionnaires were found useful for analysis. Small herds (<100 head) constituted 60% of the sample population, 33% farms were categorized as medium herds (100-499 head) and finally 7% were large herds (>500 head). Most of the herds (68%) acquired their replacements from external sources (open herds); however, preventive measures against the introduction of BVDV into the farm such as purchased animal history, quarantine and BVDV testing were not commonly performed. Even though producers commonly reported the use of BVDV vaccines, not all animals groups were vaccinated within herds. This study highlights the aspects of management practices of BVDV control on Indiana dairy farms that need reinforcement. In particular, dairy producers should be made aware that vaccination should be complementary to a comprehensive biosecurity program.Copyright © 2011 Elsevier B.V. All rights reserved.
HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms. - Molecular and cellular neurosciences
Hepatocyte growth factor (HGF) is a pleiotrophic factor whose many functions include promoting neuronal survival and growth. Hitherto, these effects have been observed in the presence of other neurotrophic factors like NGF and CNTF, and this requirement for an accessory factor has made it difficult to elucidate the signaling pathways that mediate its survival and growth-enhancing effects. Here, we show that HGF promotes the survival of mature sympathetic neurons of the superior cervical ganglion (SCG) grown at low density in defined medium lacking other neurotrophic factors. This effect was first clearly observed in cultures established from postnatal day 20 (P20) mice and became maximal by P40. HGF also enhanced the growth of neurite arbors from neurons throughout postnatal development and in the adult. HGF treatment resulted in phosphorylation of Akt and ERK1/ERK2. Preventing Akt activation with the phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 blocked the HGF survival response, and inhibition of ERK activation with the MEK inhibitors PD98059 or U0126 reduced the HGF survival response and the neurite growth-promoting effects of HGF. These results indicate that HGF promotes the survival and growth of maturing sympathetic neurons by both PI-3 kinase- and MAP kinase-dependent mechanisms.

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4585 Washington St C-3 Florissant, MO 63033
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