Dr. Ali  Salehpour  Dmd image

Dr. Ali Salehpour Dmd

678 Fellsway
Medford MA 02155
781 918-8979
Medical School: Other - Unknown
Accepts Medicare: No
Participates In eRX: No
Participates In PQRS: No
Participates In EHR: No
License #: 21626
NPI: 1023154432
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Mirage is an image in a flat ground surface. - Journal of the Optical Society of America. A, Optics, image science, and vision
Mirage is a fascinating phenomenon that has attracted many scientists to report their observations and descriptions about it. There are two different approaches to mirage formation. The more popular one is attributed to total internal reflection that occurs in the near ground air layers on hot sunny days. According to the other approach, mirage is an image in a rough surface that is observed at grazing angles of incidence. Most of the existing descriptions are qualitative and some include calculations based on guessing temperature change with no concrete experiments. In this report, first we show that Fermat's principle also concerns the wave nature of light and covers the constructive and destructive interference that is essential for image formation. Then, we provide a brief review of the image formation theory in a rough plane and demonstrate by experiments in the lab and deserts that the temperature gradient in the near ground air layers does not lead to mirage formation.
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. - Aging cell
Stress-activated protein kinase (SAPK) pathways are evolutionarily conserved signaling modules that orchestrate protective responses to adverse environmental conditions. However, under certain conditions, their activation can be deleterious. Thus, activation of the c-Jun N-terminal kinase (JNK) SAPK pathway exacerbates a diverse set of pathologies, many of which are typical of old age. The contexts determining whether the outcome of JNK signaling is protective or detrimental are not fully understood. Here, we show that the age of an animal defines such a context. The Caenorhabditis elegans JNK homolog, KGB-1, provides protection from heavy metals and protein folding stress in developing animals. However, we found that with the onset of adulthood, KGB-1 activity becomes detrimental, reducing stress resistance and lifespan. Genetic analyses coupled with fluorescent imaging linked this phenotypic switch to age-dependent antagonistic modulation of DAF-16/FOXO: KGB-1 activation enhanced DAF-16 nuclear localization and transcriptional activity during development but decreased it in adults. Epistasis analyses showed that DAF-16 was necessary and sufficient to explain some of the kgb-1-dependent detrimental phenotypes, but not all. The identification of early adulthood as a point following which the contribution of KGB-1 activity reverses from beneficial to detrimental sheds new light on the involvement of JNK signaling in age-related pathologies. Furthermore, the age-dependent reversal has intriguing implications for our understanding of aging.© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.

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